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Gene: MMP16 |
Gene summary for MMP16 |
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Gene information | Species | Human | Gene symbol | MMP16 | Gene ID | 4325 |
Gene name | matrix metallopeptidase 16 | |
Gene Alias | C8orf57 | |
Cytomap | 8q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P51512 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4325 | MMP16 | HTA12-15-2 | Human | Pancreas | PDAC | 4.32e-07 | 4.42e-01 | 0.2315 |
4325 | MMP16 | HTA12-23-1 | Human | Pancreas | PDAC | 5.20e-08 | 7.24e-01 | 0.3405 |
4325 | MMP16 | HTA12-25-1 | Human | Pancreas | PDAC | 2.41e-10 | 7.08e-01 | 0.313 |
4325 | MMP16 | HTA12-26-1 | Human | Pancreas | PDAC | 9.17e-18 | 9.07e-01 | 0.3728 |
4325 | MMP16 | HTA12-29-1 | Human | Pancreas | PDAC | 5.92e-54 | 1.13e+00 | 0.3722 |
4325 | MMP16 | HTA12-30-1 | Human | Pancreas | PDAC | 1.14e-02 | 7.33e-01 | 0.3671 |
4325 | MMP16 | HTA12-32-1 | Human | Pancreas | PDAC | 4.65e-02 | 5.96e-01 | 0.3624 |
4325 | MMP16 | male-WTA | Human | Thyroid | PTC | 5.95e-07 | 1.39e-01 | 0.1037 |
4325 | MMP16 | PTC04 | Human | Thyroid | PTC | 5.14e-03 | 1.03e-01 | 0.1927 |
4325 | MMP16 | PTC05 | Human | Thyroid | PTC | 6.87e-11 | 4.50e-01 | 0.2065 |
4325 | MMP16 | PTC06 | Human | Thyroid | PTC | 1.25e-13 | 3.86e-01 | 0.2057 |
4325 | MMP16 | PTC07 | Human | Thyroid | PTC | 4.25e-14 | 3.00e-01 | 0.2044 |
4325 | MMP16 | ATC12 | Human | Thyroid | ATC | 5.95e-07 | 1.69e-01 | 0.34 |
4325 | MMP16 | ATC13 | Human | Thyroid | ATC | 1.89e-58 | 9.83e-01 | 0.34 |
4325 | MMP16 | ATC4 | Human | Thyroid | ATC | 1.51e-10 | 2.25e-01 | 0.34 |
4325 | MMP16 | ATC5 | Human | Thyroid | ATC | 5.67e-56 | 1.05e+00 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
GO:005160420 | Thyroid | PTC | protein maturation | 132/5968 | 294/18723 | 1.71e-06 | 2.39e-05 | 132 |
GO:00603486 | Thyroid | PTC | bone development | 90/5968 | 205/18723 | 1.89e-04 | 1.42e-03 | 90 |
GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
GO:00164859 | Thyroid | PTC | protein processing | 95/5968 | 225/18723 | 6.60e-04 | 4.15e-03 | 95 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:006034813 | Thyroid | ATC | bone development | 102/6293 | 205/18723 | 1.18e-06 | 1.52e-05 | 102 |
GO:0051604110 | Thyroid | ATC | protein maturation | 136/6293 | 294/18723 | 4.00e-06 | 4.42e-05 | 136 |
GO:0060349 | Thyroid | ATC | bone morphogenesis | 50/6293 | 93/18723 | 4.87e-05 | 3.88e-04 | 50 |
GO:00487053 | Thyroid | ATC | skeletal system morphogenesis | 101/6293 | 220/18723 | 9.48e-05 | 6.93e-04 | 101 |
GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
GO:001648515 | Thyroid | ATC | protein processing | 100/6293 | 225/18723 | 4.39e-04 | 2.62e-03 | 100 |
GO:19048882 | Thyroid | ATC | cranial skeletal system development | 35/6293 | 68/18723 | 1.76e-03 | 8.71e-03 | 35 |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
GO:0060350 | Thyroid | ATC | endochondral bone morphogenesis | 28/6293 | 54/18723 | 4.27e-03 | 1.80e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MMP16 | SNV | Missense_Mutation | c.1157N>T | p.Arg386Leu | p.R386L | P51512 | protein_coding | deleterious(0.04) | benign(0.313) | TCGA-H2-A2K9-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4325 | MMP16 | CELL SURFACE, DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 252166829 | ||
4325 | MMP16 | CELL SURFACE, DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 178103981 | ILOMASTAT |
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