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Gene: KMT2E |
Gene summary for KMT2E |
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Gene information | Species | Human | Gene symbol | KMT2E | Gene ID | 55904 |
Gene name | lysine methyltransferase 2E (inactive) | |
Gene Alias | HDCMC04P | |
Cytomap | 7q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q8IZD2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55904 | KMT2E | CA_HPV_1 | Human | Cervix | CC | 2.94e-06 | -1.08e-01 | 0.0264 |
55904 | KMT2E | CCI_1 | Human | Cervix | CC | 7.00e-11 | 1.21e+00 | 0.528 |
55904 | KMT2E | CCI_2 | Human | Cervix | CC | 6.58e-09 | 6.02e-01 | 0.5249 |
55904 | KMT2E | CCI_3 | Human | Cervix | CC | 2.82e-09 | 9.36e-01 | 0.516 |
55904 | KMT2E | L1 | Human | Cervix | CC | 1.11e-09 | -2.69e-01 | 0.0802 |
55904 | KMT2E | T1 | Human | Cervix | CC | 6.15e-04 | -2.86e-01 | 0.0918 |
55904 | KMT2E | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.05e-37 | -7.32e-01 | 0.0155 |
55904 | KMT2E | HTA11_347_2000001011 | Human | Colorectum | AD | 3.89e-10 | 5.40e-01 | -0.1954 |
55904 | KMT2E | HTA11_8622_2000001021 | Human | Colorectum | SER | 7.13e-04 | -5.32e-01 | 0.0528 |
55904 | KMT2E | HTA11_11156_2000001011 | Human | Colorectum | AD | 4.05e-04 | -7.02e-01 | 0.0397 |
55904 | KMT2E | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.67e-04 | -3.97e-01 | 0.294 |
55904 | KMT2E | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.08e-03 | 4.74e-01 | 0.281 |
55904 | KMT2E | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.11e-17 | -5.70e-01 | 0.3005 |
55904 | KMT2E | F007 | Human | Colorectum | FAP | 4.39e-02 | -1.69e-01 | 0.1176 |
55904 | KMT2E | A001-C-207 | Human | Colorectum | FAP | 1.10e-08 | -4.29e-01 | 0.1278 |
55904 | KMT2E | A015-C-203 | Human | Colorectum | FAP | 1.79e-32 | -2.67e-01 | -0.1294 |
55904 | KMT2E | A015-C-204 | Human | Colorectum | FAP | 3.51e-05 | -2.22e-01 | -0.0228 |
55904 | KMT2E | A014-C-040 | Human | Colorectum | FAP | 1.08e-06 | -1.96e-01 | -0.1184 |
55904 | KMT2E | A002-C-201 | Human | Colorectum | FAP | 8.47e-19 | -3.73e-01 | 0.0324 |
55904 | KMT2E | A001-C-119 | Human | Colorectum | FAP | 1.31e-08 | -5.88e-02 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003009910 | Cervix | CC | myeloid cell differentiation | 83/2311 | 381/18723 | 1.31e-07 | 6.42e-06 | 83 |
GO:000226210 | Cervix | CC | myeloid cell homeostasis | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:00447725 | Cervix | CC | mitotic cell cycle phase transition | 89/2311 | 424/18723 | 2.70e-07 | 1.12e-05 | 89 |
GO:003410110 | Cervix | CC | erythrocyte homeostasis | 37/2311 | 129/18723 | 5.16e-07 | 1.93e-05 | 37 |
GO:003021810 | Cervix | CC | erythrocyte differentiation | 34/2311 | 120/18723 | 2.00e-06 | 6.18e-05 | 34 |
GO:004887210 | Cervix | CC | homeostasis of number of cells | 61/2311 | 272/18723 | 2.17e-06 | 6.55e-05 | 61 |
GO:20000453 | Cervix | CC | regulation of G1/S transition of mitotic cell cycle | 37/2311 | 142/18723 | 6.33e-06 | 1.53e-04 | 37 |
GO:00457876 | Cervix | CC | positive regulation of cell cycle | 66/2311 | 313/18723 | 7.78e-06 | 1.81e-04 | 66 |
GO:00000824 | Cervix | CC | G1/S transition of mitotic cell cycle | 49/2311 | 214/18723 | 1.16e-05 | 2.48e-04 | 49 |
GO:19028062 | Cervix | CC | regulation of cell cycle G1/S phase transition | 41/2311 | 168/18723 | 1.18e-05 | 2.51e-04 | 41 |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:19019903 | Cervix | CC | regulation of mitotic cell cycle phase transition | 63/2311 | 299/18723 | 1.27e-05 | 2.60e-04 | 63 |
GO:00448434 | Cervix | CC | cell cycle G1/S phase transition | 53/2311 | 241/18723 | 1.76e-05 | 3.32e-04 | 53 |
GO:00459316 | Cervix | CC | positive regulation of mitotic cell cycle | 32/2311 | 121/18723 | 1.88e-05 | 3.47e-04 | 32 |
GO:19019922 | Cervix | CC | positive regulation of mitotic cell cycle phase transition | 26/2311 | 93/18723 | 3.97e-05 | 6.18e-04 | 26 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00900685 | Cervix | CC | positive regulation of cell cycle process | 50/2311 | 236/18723 | 8.25e-05 | 1.11e-03 | 50 |
GO:19019873 | Cervix | CC | regulation of cell cycle phase transition | 74/2311 | 390/18723 | 9.80e-05 | 1.27e-03 | 74 |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:19019892 | Cervix | CC | positive regulation of cell cycle phase transition | 28/2311 | 115/18723 | 2.82e-04 | 3.07e-03 | 28 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00310 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa003101 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa003102 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
hsa003103 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
hsa003104 | Colorectum | FAP | Lysine degradation | 23/1404 | 63/8465 | 1.04e-04 | 9.46e-04 | 5.76e-04 | 23 |
hsa003105 | Colorectum | FAP | Lysine degradation | 23/1404 | 63/8465 | 1.04e-04 | 9.46e-04 | 5.76e-04 | 23 |
hsa0031010 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa0031013 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa003108 | Liver | NAFLD | Lysine degradation | 21/1043 | 63/8465 | 1.09e-05 | 3.58e-04 | 2.89e-04 | 21 |
hsa0031011 | Liver | NAFLD | Lysine degradation | 21/1043 | 63/8465 | 1.09e-05 | 3.58e-04 | 2.89e-04 | 21 |
hsa0031021 | Liver | Cirrhotic | Lysine degradation | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa0031031 | Liver | Cirrhotic | Lysine degradation | 29/2530 | 63/8465 | 4.81e-03 | 1.74e-02 | 1.07e-02 | 29 |
hsa0031041 | Liver | HCC | Lysine degradation | 47/4020 | 63/8465 | 1.02e-05 | 7.58e-05 | 4.22e-05 | 47 |
hsa0031051 | Liver | HCC | Lysine degradation | 47/4020 | 63/8465 | 1.02e-05 | 7.58e-05 | 4.22e-05 | 47 |
hsa003109 | Lung | IAC | Lysine degradation | 17/1053 | 63/8465 | 1.35e-03 | 8.63e-03 | 5.73e-03 | 17 |
hsa0031012 | Lung | IAC | Lysine degradation | 17/1053 | 63/8465 | 1.35e-03 | 8.63e-03 | 5.73e-03 | 17 |
hsa0031022 | Lung | AIS | Lysine degradation | 16/961 | 63/8465 | 1.41e-03 | 9.49e-03 | 6.07e-03 | 16 |
hsa0031032 | Lung | AIS | Lysine degradation | 16/961 | 63/8465 | 1.41e-03 | 9.49e-03 | 6.07e-03 | 16 |
hsa0031042 | Lung | MIAC | Lysine degradation | 10/507 | 63/8465 | 3.93e-03 | 3.18e-02 | 2.30e-02 | 10 |
hsa0031052 | Lung | MIAC | Lysine degradation | 10/507 | 63/8465 | 3.93e-03 | 3.18e-02 | 2.30e-02 | 10 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KMT2E | SNV | Missense_Mutation | c.4522G>A | p.Ala1508Thr | p.A1508T | Q8IZD2 | protein_coding | tolerated_low_confidence(0.13) | benign(0) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KMT2E | SNV | Missense_Mutation | c.1655N>C | p.Lys552Thr | p.K552T | Q8IZD2 | protein_coding | deleterious(0.03) | possibly_damaging(0.556) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
KMT2E | SNV | Missense_Mutation | c.2482N>C | p.Asn828His | p.N828H | Q8IZD2 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.656) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
KMT2E | SNV | Missense_Mutation | novel | c.668N>C | p.Val223Ala | p.V223A | Q8IZD2 | protein_coding | tolerated(0.15) | benign(0.144) | TCGA-BR-A4IU-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
KMT2E | SNV | Missense_Mutation | c.4810G>C | p.Val1604Leu | p.V1604L | Q8IZD2 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.964) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KMT2E | SNV | Missense_Mutation | c.5203N>C | p.Ser1735Pro | p.S1735P | Q8IZD2 | protein_coding | tolerated_low_confidence(0.21) | benign(0) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KMT2E | SNV | Missense_Mutation | rs374000573 | c.5419N>G | p.Thr1807Ala | p.T1807A | Q8IZD2 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KMT2E | SNV | Missense_Mutation | novel | c.1822G>A | p.Ala608Thr | p.A608T | Q8IZD2 | protein_coding | deleterious(0.05) | benign(0.182) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
KMT2E | SNV | Missense_Mutation | rs370792273 | c.4364C>T | p.Thr1455Met | p.T1455M | Q8IZD2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
KMT2E | SNV | Missense_Mutation | c.17N>A | p.Pro6Gln | p.P6Q | Q8IZD2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.671) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55904 | KMT2E | ENZYME, METHYL TRANSFERASE | duloxetine | DULOXETINE | 28696415 |
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