![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: HFM1 |
Gene summary for HFM1 |
![]() |
Gene information | Species | Human | Gene symbol | HFM1 | Gene ID | 164045 |
Gene name | helicase for meiosis 1 | |
Gene Alias | MER3 | |
Cytomap | 1p22.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A2PYH4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
164045 | HFM1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.45e-05 | 2.00e-01 | 0.0155 |
164045 | HFM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.26e-17 | 5.40e-01 | -0.1808 |
164045 | HFM1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.01e-08 | 9.04e-01 | 0.0216 |
164045 | HFM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.15e-13 | 7.32e-01 | -0.0811 |
164045 | HFM1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.43e-12 | 3.38e-01 | -0.1088 |
164045 | HFM1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.48e-33 | 6.14e-01 | -0.1954 |
164045 | HFM1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.83e-04 | 3.96e-01 | -0.2602 |
164045 | HFM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.35e-10 | 8.74e-01 | -0.2196 |
164045 | HFM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.53e-16 | 5.38e-01 | -0.1207 |
164045 | HFM1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.55e-13 | 5.24e-01 | -0.1526 |
164045 | HFM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.32e-21 | 4.69e-01 | -0.1464 |
164045 | HFM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.14e-46 | 9.64e-01 | -0.1001 |
164045 | HFM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.90e-33 | 8.84e-01 | -0.059 |
164045 | HFM1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.07e-21 | 9.63e-01 | -0.1706 |
164045 | HFM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.40e-05 | 3.55e-01 | -0.2061 |
164045 | HFM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.64e-18 | 8.85e-01 | -0.1462 |
164045 | HFM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-10 | 4.07e-01 | -0.0842 |
164045 | HFM1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.89e-04 | 3.96e-01 | -0.00410000000000005 |
164045 | HFM1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.61e-02 | 2.62e-01 | -0.0179 |
164045 | HFM1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.40e-18 | 5.33e-01 | 0.096 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032392 | Colorectum | AD | DNA geometric change | 31/3918 | 90/18723 | 2.02e-03 | 1.63e-02 | 31 |
GO:00323921 | Colorectum | MSS | DNA geometric change | 29/3467 | 90/18723 | 1.26e-03 | 1.20e-02 | 29 |
GO:0032508 | Colorectum | MSS | DNA duplex unwinding | 25/3467 | 84/18723 | 8.27e-03 | 4.99e-02 | 25 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HFM1 | SNV | Missense_Mutation | c.763N>A | p.Glu255Lys | p.E255K | A2PYH4 | protein_coding | tolerated(0.8) | benign(0) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | novel | c.1804T>C | p.Phe602Leu | p.F602L | A2PYH4 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HFM1 | SNV | Missense_Mutation | novel | c.1904N>G | p.Tyr635Cys | p.Y635C | A2PYH4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D6-A6EK-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PR |
HFM1 | SNV | Missense_Mutation | rs772600370 | c.2374N>C | p.Glu792Gln | p.E792Q | A2PYH4 | protein_coding | tolerated(0.08) | benign(0.213) | TCGA-HD-8314-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR |
HFM1 | SNV | Missense_Mutation | rs377647325 | c.3106N>T | p.Ala1036Ser | p.A1036S | A2PYH4 | protein_coding | tolerated(0.28) | benign(0.135) | TCGA-UF-A718-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HFM1 | SNV | Missense_Mutation | c.3105N>A | p.Asp1035Glu | p.D1035E | A2PYH4 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-UF-A718-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | rs146051438 | c.803C>T | p.Pro268Leu | p.P268L | A2PYH4 | protein_coding | deleterious(0.04) | probably_damaging(0.964) | TCGA-EJ-5511-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
HFM1 | SNV | Missense_Mutation | c.634N>G | p.Lys212Glu | p.K212E | A2PYH4 | protein_coding | tolerated_low_confidence(0.45) | benign(0.3) | TCGA-EJ-7123-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | c.1741N>C | p.Asp581His | p.D581H | A2PYH4 | protein_coding | tolerated(0.5) | benign(0) | TCGA-EJ-8472-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | PD | |
HFM1 | SNV | Missense_Mutation | c.420N>C | p.Lys140Asn | p.K140N | A2PYH4 | protein_coding | tolerated_low_confidence(0.32) | benign(0.051) | TCGA-HC-7213-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |