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Gene: HCFC1 |
Gene summary for HCFC1 |
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Gene information | Species | Human | Gene symbol | HCFC1 | Gene ID | 3054 |
Gene name | host cell factor C1 | |
Gene Alias | CFF | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P51610 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3054 | HCFC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.44e-04 | 3.18e-01 | -0.0811 |
3054 | HCFC1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.18e-03 | 2.27e-01 | -0.1954 |
3054 | HCFC1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.27e-04 | 2.49e-01 | -0.1464 |
3054 | HCFC1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.31e-05 | 3.52e-01 | -0.059 |
3054 | HCFC1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.06e-10 | 3.52e-01 | 0.096 |
3054 | HCFC1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.91e-08 | 3.10e-01 | 0.0674 |
3054 | HCFC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.93e-10 | 4.01e-01 | 0.294 |
3054 | HCFC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.92e-03 | 1.82e-01 | 0.281 |
3054 | HCFC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.26e-22 | 5.75e-01 | 0.3859 |
3054 | HCFC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.76e-06 | 5.32e-01 | 0.2585 |
3054 | HCFC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.64e-05 | 2.66e-01 | 0.3005 |
3054 | HCFC1 | LZE2T | Human | Esophagus | ESCC | 5.27e-05 | 6.63e-01 | 0.082 |
3054 | HCFC1 | LZE4T | Human | Esophagus | ESCC | 6.91e-04 | 4.64e-02 | 0.0811 |
3054 | HCFC1 | LZE7T | Human | Esophagus | ESCC | 5.37e-11 | 6.87e-01 | 0.0667 |
3054 | HCFC1 | LZE8T | Human | Esophagus | ESCC | 1.03e-10 | 1.80e-01 | 0.067 |
3054 | HCFC1 | LZE20T | Human | Esophagus | ESCC | 1.57e-07 | 1.55e-01 | 0.0662 |
3054 | HCFC1 | LZE24T | Human | Esophagus | ESCC | 1.00e-14 | 3.64e-01 | 0.0596 |
3054 | HCFC1 | LZE6T | Human | Esophagus | ESCC | 2.20e-05 | 2.37e-01 | 0.0845 |
3054 | HCFC1 | P1T-E | Human | Esophagus | ESCC | 2.64e-15 | 5.95e-01 | 0.0875 |
3054 | HCFC1 | P2T-E | Human | Esophagus | ESCC | 3.94e-37 | 7.67e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00160322 | Colorectum | MSS | viral process | 157/3467 | 415/18723 | 7.94e-21 | 6.19e-18 | 157 |
GO:00316472 | Colorectum | MSS | regulation of protein stability | 103/3467 | 298/18723 | 2.52e-11 | 3.49e-09 | 103 |
GO:00432542 | Colorectum | MSS | regulation of protein-containing complex assembly | 130/3467 | 428/18723 | 1.38e-09 | 1.03e-07 | 130 |
GO:00508212 | Colorectum | MSS | protein stabilization | 68/3467 | 191/18723 | 1.53e-08 | 8.81e-07 | 68 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00457871 | Colorectum | MSS | positive regulation of cell cycle | 80/3467 | 313/18723 | 1.15e-03 | 1.12e-02 | 80 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:0050821111 | Esophagus | ESCC | protein stabilization | 140/8552 | 191/18723 | 6.50e-15 | 3.61e-13 | 140 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HCFC1 | TH17 | Oral cavity | EOLP | COCH,NRDE2,CCDC58, etc. | 1.33e-01 | ![]() |
HCFC1 | STM | Thyroid | Healthy | TRIM33,UBAP2L,SF3A3, etc. | 5.30e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HCFC1 | SNV | Missense_Mutation | c.680N>A | p.Cys227Tyr | p.C227Y | P51610 | protein_coding | deleterious(0.03) | possibly_damaging(0.557) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HCFC1 | SNV | Missense_Mutation | novel | c.514G>T | p.Asp172Tyr | p.D172Y | P51610 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
HCFC1 | SNV | Missense_Mutation | rs782239008 | c.4217N>T | p.Ala1406Val | p.A1406V | P51610 | protein_coding | tolerated_low_confidence(0.29) | benign(0) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
HCFC1 | SNV | Missense_Mutation | rs782354655 | c.722N>T | p.Thr241Met | p.T241M | P51610 | protein_coding | deleterious(0.01) | possibly_damaging(0.732) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
HCFC1 | SNV | Missense_Mutation | c.3826N>A | p.Glu1276Lys | p.E1276K | P51610 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.899) | TCGA-CD-8529-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | epirubicin | CR | |
HCFC1 | SNV | Missense_Mutation | c.2723C>T | p.Thr908Met | p.T908M | P51610 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HCFC1 | SNV | Missense_Mutation | c.650A>G | p.Lys217Arg | p.K217R | P51610 | protein_coding | tolerated(0.95) | benign(0.071) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HCFC1 | SNV | Missense_Mutation | c.2953N>A | p.Pro985Thr | p.P985T | P51610 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.987) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
HCFC1 | SNV | Missense_Mutation | c.4211N>A | p.Gly1404Asp | p.G1404D | P51610 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
HCFC1 | SNV | Missense_Mutation | c.1099N>A | p.Pro367Thr | p.P367T | P51610 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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