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Gene: DOPEY1 |
Gene summary for DOPEY1 |
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Gene information | Species | Human | Gene symbol | DOPEY1 | Gene ID | 23033 |
Gene name | DOP1 leucine zipper like protein A | |
Gene Alias | DOP1 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5TA12 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23033 | DOPEY1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.27e-41 | -8.93e-01 | 0.0155 |
23033 | DOPEY1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.62e-25 | -8.93e-01 | -0.1808 |
23033 | DOPEY1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.04e-06 | -8.93e-01 | 0.0216 |
23033 | DOPEY1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.46e-20 | -8.93e-01 | -0.0811 |
23033 | DOPEY1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.20e-29 | -8.93e-01 | -0.1088 |
23033 | DOPEY1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.39e-44 | -8.93e-01 | -0.1954 |
23033 | DOPEY1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.24e-04 | -8.93e-01 | -0.2602 |
23033 | DOPEY1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.13e-06 | -8.93e-01 | -0.2196 |
23033 | DOPEY1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-20 | -8.93e-01 | -0.1207 |
23033 | DOPEY1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.50e-17 | -8.93e-01 | -0.1526 |
23033 | DOPEY1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.20e-62 | -8.93e-01 | -0.1464 |
23033 | DOPEY1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.40e-59 | -8.93e-01 | -0.1001 |
23033 | DOPEY1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.72e-34 | -8.93e-01 | -0.059 |
23033 | DOPEY1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.88e-08 | -8.93e-01 | -0.1706 |
23033 | DOPEY1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.01e-09 | -8.93e-01 | -0.2061 |
23033 | DOPEY1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.04e-06 | -8.93e-01 | -0.1462 |
23033 | DOPEY1 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.96e-15 | -8.93e-01 | -0.0842 |
23033 | DOPEY1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.24e-04 | -8.93e-01 | -0.00410000000000005 |
23033 | DOPEY1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.51e-12 | -8.93e-01 | -0.0179 |
23033 | DOPEY1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.39e-37 | -8.93e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOPEY1 | SNV | Missense_Mutation | c.881N>A | p.Gly294Glu | p.G294E | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | ||
DOPEY1 | SNV | Missense_Mutation | c.2311N>G | p.Thr771Ala | p.T771A | protein_coding | tolerated(0.76) | benign(0) | TCGA-50-5946-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
DOPEY1 | SNV | Missense_Mutation | c.742G>A | p.Asp248Asn | p.D248N | protein_coding | deleterious(0) | possibly_damaging(0.549) | TCGA-78-7166-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
DOPEY1 | SNV | Missense_Mutation | c.4883A>C | p.Gln1628Pro | p.Q1628P | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | ||
DOPEY1 | SNV | Missense_Mutation | novel | c.1285N>C | p.Val429Leu | p.V429L | protein_coding | tolerated(0.22) | benign(0.001) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DOPEY1 | SNV | Missense_Mutation | c.4291N>G | p.Pro1431Ala | p.P1431A | protein_coding | tolerated(0.42) | probably_damaging(0.986) | TCGA-93-A4JO-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
DOPEY1 | SNV | Missense_Mutation | novel | c.2794A>G | p.Arg932Gly | p.R932G | protein_coding | deleterious(0) | possibly_damaging(0.72) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DOPEY1 | SNV | Missense_Mutation | c.481T>C | p.Tyr161His | p.Y161H | protein_coding | deleterious(0) | possibly_damaging(0.537) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
DOPEY1 | SNV | Missense_Mutation | novel | c.4986N>T | p.Met1662Ile | p.M1662I | protein_coding | tolerated(0.06) | possibly_damaging(0.835) | TCGA-18-3421-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DOPEY1 | SNV | Missense_Mutation | novel | c.2504N>G | p.Asn835Ser | p.N835S | protein_coding | tolerated(0.18) | benign(0.012) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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