|
Gene: CELSR1 |
Gene summary for CELSR1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CELSR1 | Gene ID | 9620 |
Gene name | cadherin EGF LAG seven-pass G-type receptor 1 | |
Gene Alias | ADGRC1 | |
Cytomap | 22q13.31 | |
Gene Type | protein-coding | GO ID | GO:0001736 | UniProtAcc | Q9NYQ6 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9620 | CELSR1 | GSM4909293 | Human | Breast | IDC | 2.75e-04 | 1.51e-01 | 0.1581 |
9620 | CELSR1 | GSM4909306 | Human | Breast | IDC | 6.31e-06 | 1.88e-01 | 0.1564 |
9620 | CELSR1 | GSM4909307 | Human | Breast | IDC | 6.87e-07 | 2.37e-01 | 0.1569 |
9620 | CELSR1 | GSM4909308 | Human | Breast | IDC | 2.12e-07 | 2.24e-01 | 0.158 |
9620 | CELSR1 | GSM4909317 | Human | Breast | IDC | 9.13e-05 | 1.59e-01 | 0.1355 |
9620 | CELSR1 | M5 | Human | Breast | IDC | 2.00e-02 | 3.32e-01 | 0.1598 |
9620 | CELSR1 | NCCBC2 | Human | Breast | DCIS | 2.73e-03 | 5.40e-01 | 0.1554 |
9620 | CELSR1 | P3 | Human | Breast | IDC | 2.53e-06 | 5.17e-01 | 0.1542 |
9620 | CELSR1 | DCIS2 | Human | Breast | DCIS | 6.56e-05 | 1.61e-02 | 0.0085 |
9620 | CELSR1 | CA_HPV_1 | Human | Cervix | CC | 1.81e-04 | -1.12e-01 | 0.0264 |
9620 | CELSR1 | CCI_1 | Human | Cervix | CC | 2.36e-20 | 1.57e+00 | 0.528 |
9620 | CELSR1 | CCI_2 | Human | Cervix | CC | 2.47e-03 | 4.05e-01 | 0.5249 |
9620 | CELSR1 | CCI_3 | Human | Cervix | CC | 1.66e-21 | 8.72e-01 | 0.516 |
9620 | CELSR1 | sample3 | Human | Cervix | CC | 2.83e-03 | 1.91e-01 | 0.1387 |
9620 | CELSR1 | AEH-subject1 | Human | Endometrium | AEH | 4.66e-09 | 3.57e-01 | -0.3059 |
9620 | CELSR1 | AEH-subject3 | Human | Endometrium | AEH | 7.57e-08 | 3.66e-01 | -0.2576 |
9620 | CELSR1 | AEH-subject5 | Human | Endometrium | AEH | 1.78e-21 | 6.42e-01 | -0.2953 |
9620 | CELSR1 | EEC-subject2 | Human | Endometrium | EEC | 6.75e-13 | 4.51e-01 | -0.2607 |
9620 | CELSR1 | EEC-subject4 | Human | Endometrium | EEC | 1.57e-02 | 2.78e-01 | -0.2571 |
9620 | CELSR1 | EEC-subject5 | Human | Endometrium | EEC | 1.24e-05 | 2.99e-01 | -0.249 |
Page: 1 2 3 4 5 6 7 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003297014 | Breast | IDC | regulation of actin filament-based process | 56/1434 | 397/18723 | 6.37e-06 | 1.99e-04 | 56 |
GO:003295614 | Breast | IDC | regulation of actin cytoskeleton organization | 48/1434 | 358/18723 | 1.03e-04 | 1.96e-03 | 48 |
GO:006056212 | Breast | IDC | epithelial tube morphogenesis | 44/1434 | 325/18723 | 1.58e-04 | 2.73e-03 | 44 |
GO:00303244 | Breast | IDC | lung development | 28/1434 | 177/18723 | 1.90e-04 | 3.15e-03 | 28 |
GO:00303234 | Breast | IDC | respiratory tube development | 28/1434 | 181/18723 | 2.78e-04 | 4.26e-03 | 28 |
GO:00611383 | Breast | IDC | morphogenesis of a branching epithelium | 28/1434 | 182/18723 | 3.05e-04 | 4.60e-03 | 28 |
GO:00605412 | Breast | IDC | respiratory system development | 30/1434 | 203/18723 | 3.85e-04 | 5.40e-03 | 30 |
GO:00017635 | Breast | IDC | morphogenesis of a branching structure | 29/1434 | 196/18723 | 4.68e-04 | 6.26e-03 | 29 |
GO:003514812 | Breast | IDC | tube formation | 23/1434 | 148/18723 | 8.79e-04 | 1.02e-02 | 23 |
GO:000183812 | Breast | IDC | embryonic epithelial tube formation | 19/1434 | 121/18723 | 2.10e-03 | 1.97e-02 | 19 |
GO:0048754 | Breast | IDC | branching morphogenesis of an epithelial tube | 22/1434 | 151/18723 | 2.61e-03 | 2.34e-02 | 22 |
GO:0060441 | Breast | IDC | epithelial tube branching involved in lung morphogenesis | 7/1434 | 29/18723 | 5.31e-03 | 3.94e-02 | 7 |
GO:00721756 | Breast | IDC | epithelial tube formation | 19/1434 | 132/18723 | 5.63e-03 | 4.08e-02 | 19 |
GO:003297024 | Breast | DCIS | regulation of actin filament-based process | 56/1390 | 397/18723 | 2.50e-06 | 8.74e-05 | 56 |
GO:003295624 | Breast | DCIS | regulation of actin cytoskeleton organization | 48/1390 | 358/18723 | 4.82e-05 | 9.92e-04 | 48 |
GO:003032413 | Breast | DCIS | lung development | 27/1390 | 177/18723 | 2.73e-04 | 4.09e-03 | 27 |
GO:003032313 | Breast | DCIS | respiratory tube development | 27/1390 | 181/18723 | 3.93e-04 | 5.41e-03 | 27 |
GO:006056221 | Breast | DCIS | epithelial tube morphogenesis | 41/1390 | 325/18723 | 5.98e-04 | 7.60e-03 | 41 |
GO:006054111 | Breast | DCIS | respiratory system development | 28/1390 | 203/18723 | 1.10e-03 | 1.19e-02 | 28 |
GO:006113811 | Breast | DCIS | morphogenesis of a branching epithelium | 25/1390 | 182/18723 | 2.08e-03 | 1.94e-02 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CELSR1 | SNV | Missense_Mutation | c.1748C>A | p.Pro583His | p.P583H | Q9NYQ6 | protein_coding | deleterious(0) | benign(0.067) | TCGA-BC-A10T-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
CELSR1 | SNV | Missense_Mutation | c.5507G>T | p.Gly1836Val | p.G1836V | Q9NYQ6 | protein_coding | deleterious(0) | possibly_damaging(0.475) | TCGA-BD-A3EP-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CELSR1 | SNV | Missense_Mutation | c.2230N>G | p.Ile744Val | p.I744V | Q9NYQ6 | protein_coding | tolerated(0.35) | benign(0.268) | TCGA-CC-A7IG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CELSR1 | SNV | Missense_Mutation | rs533045376 | c.7583N>T | p.Pro2528Leu | p.P2528L | Q9NYQ6 | protein_coding | deleterious(0.03) | probably_damaging(0.946) | TCGA-FV-A4ZP-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
CELSR1 | SNV | Missense_Mutation | c.5722N>T | p.Val1908Leu | p.V1908L | Q9NYQ6 | protein_coding | tolerated(0.06) | benign(0.013) | TCGA-FV-A4ZQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CELSR1 | SNV | Missense_Mutation | novel | c.6370A>G | p.Thr2124Ala | p.T2124A | Q9NYQ6 | protein_coding | deleterious(0.03) | possibly_damaging(0.714) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CELSR1 | SNV | Missense_Mutation | novel | c.5263N>T | p.Gly1755Cys | p.G1755C | Q9NYQ6 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CELSR1 | SNV | Missense_Mutation | novel | c.1678N>T | p.Asp560Tyr | p.D560Y | Q9NYQ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CELSR1 | SNV | Missense_Mutation | rs775503253 | c.4555N>T | p.Pro1519Ser | p.P1519S | Q9NYQ6 | protein_coding | deleterious(0.04) | benign(0.386) | TCGA-44-6144-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CELSR1 | SNV | Missense_Mutation | c.7130N>A | p.Thr2377Lys | p.T2377K | Q9NYQ6 | protein_coding | deleterious(0.01) | possibly_damaging(0.642) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |