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Gene: BRINP3 |
Gene summary for BRINP3 |
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Gene information | Species | Human | Gene symbol | BRINP3 | Gene ID | 339479 |
Gene name | BMP/retinoic acid inducible neural specific 3 | |
Gene Alias | DBCCR1L | |
Cytomap | 1q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | Q76B58 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339479 | BRINP3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.85e-39 | -1.05e+00 | 0.0155 |
339479 | BRINP3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.04e-06 | -1.04e+00 | 0.0216 |
339479 | BRINP3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.43e-15 | -9.73e-01 | -0.0811 |
339479 | BRINP3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.93e-04 | -9.66e-01 | -0.2196 |
339479 | BRINP3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.02e-10 | -7.97e-01 | -0.1207 |
339479 | BRINP3 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.17e-25 | -6.57e-01 | -0.1464 |
339479 | BRINP3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.29e-20 | -6.60e-01 | -0.1001 |
339479 | BRINP3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.33e-24 | -9.12e-01 | -0.059 |
339479 | BRINP3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.44e-05 | -9.12e-01 | -0.1706 |
339479 | BRINP3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.06e-03 | -7.40e-01 | -0.1462 |
339479 | BRINP3 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.48e-05 | -6.87e-01 | -0.0842 |
339479 | BRINP3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.80e-08 | -5.33e-01 | -0.0179 |
339479 | BRINP3 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.49e-36 | -1.06e+00 | 0.096 |
339479 | BRINP3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.39e-02 | -8.53e-01 | 0.0446 |
339479 | BRINP3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.14e-05 | -1.08e+00 | 0.0451 |
339479 | BRINP3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.04e-09 | -1.03e+00 | 0.0528 |
339479 | BRINP3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.29e-03 | -8.06e-01 | 0.0171 |
339479 | BRINP3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.01e-17 | -9.51e-01 | 0.0338 |
339479 | BRINP3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.28e-62 | -1.06e+00 | 0.0674 |
339479 | BRINP3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.47e-11 | -1.05e+00 | 0.0112 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:00073461 | Colorectum | MSS | regulation of mitotic cell cycle | 108/3467 | 457/18723 | 3.30e-03 | 2.50e-02 | 108 |
GO:00073462 | Colorectum | FAP | regulation of mitotic cell cycle | 85/2622 | 457/18723 | 3.41e-03 | 2.48e-02 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRINP3 | SNV | Missense_Mutation | c.2282N>G | p.Thr761Arg | p.T761R | Q76B58 | protein_coding | tolerated(0.07) | probably_damaging(0.993) | TCGA-18-5592-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BRINP3 | SNV | Missense_Mutation | rs779280815 | c.364C>A | p.Gln122Lys | p.Q122K | Q76B58 | protein_coding | tolerated(0.09) | benign(0.12) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BRINP3 | SNV | Missense_Mutation | rs748757778 | c.2126N>A | p.Arg709His | p.R709H | Q76B58 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-21-5786-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
BRINP3 | SNV | Missense_Mutation | c.1609N>A | p.Leu537Met | p.L537M | Q76B58 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
BRINP3 | SNV | Missense_Mutation | c.654N>A | p.Ser218Arg | p.S218R | Q76B58 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BRINP3 | SNV | Missense_Mutation | rs144952455 | c.326N>A | p.Arg109His | p.R109H | Q76B58 | protein_coding | tolerated(0.18) | benign(0.018) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BRINP3 | SNV | Missense_Mutation | novel | c.197N>A | p.Arg66Lys | p.R66K | Q76B58 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-33-4532-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BRINP3 | SNV | Missense_Mutation | c.1699N>T | p.Pro567Ser | p.P567S | Q76B58 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-33-4538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
BRINP3 | SNV | Missense_Mutation | c.1169N>T | p.Ser390Ile | p.S390I | Q76B58 | protein_coding | tolerated(0.48) | benign(0) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BRINP3 | SNV | Missense_Mutation | novel | c.2284N>T | p.Thr762Ser | p.T762S | Q76B58 | protein_coding | tolerated(0.56) | probably_damaging(0.935) | TCGA-33-AAS8-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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