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Gene: ANO4 |
Gene summary for ANO4 |
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Gene information | Species | Human | Gene symbol | ANO4 | Gene ID | 121601 |
Gene name | anoctamin 4 | |
Gene Alias | TMEM16D | |
Cytomap | 12q23.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B7Z9Z0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
121601 | ANO4 | ATC13 | Human | Thyroid | ATC | 3.04e-38 | 6.37e-01 | 0.34 |
121601 | ANO4 | ATC5 | Human | Thyroid | ATC | 2.12e-37 | 6.83e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANO4 | SNV | Missense_Mutation | c.2513G>T | p.Arg838Leu | p.R838L | Q32M45 | protein_coding | tolerated(0.1) | benign(0.376) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ANO4 | SNV | Missense_Mutation | c.2135N>G | p.Glu712Gly | p.E712G | Q32M45 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ANO4 | SNV | Missense_Mutation | c.929N>T | p.Thr310Ile | p.T310I | Q32M45 | protein_coding | tolerated(0.19) | possibly_damaging(0.859) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANO4 | SNV | Missense_Mutation | rs372521580 | c.628C>T | p.Arg210Trp | p.R210W | Q32M45 | protein_coding | tolerated(0.23) | possibly_damaging(0.719) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
ANO4 | SNV | Missense_Mutation | novel | c.430N>T | p.Ala144Ser | p.A144S | Q32M45 | protein_coding | tolerated(0.29) | benign(0.323) | TCGA-BR-8686-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ANO4 | SNV | Missense_Mutation | c.1311G>C | p.Trp437Cys | p.W437C | Q32M45 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CD-8533-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | capecitabine | PD | |
ANO4 | SNV | Missense_Mutation | novel | c.2588A>C | p.Asp863Ala | p.D863A | Q32M45 | protein_coding | tolerated(0.51) | benign(0.007) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ANO4 | SNV | Missense_Mutation | c.422A>G | p.Asn141Ser | p.N141S | Q32M45 | protein_coding | tolerated(0.07) | possibly_damaging(0.889) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ANO4 | SNV | Missense_Mutation | rs765804915 | c.1441N>T | p.Arg481Trp | p.R481W | Q32M45 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-D7-8579-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracilum | CR |
ANO4 | SNV | Missense_Mutation | c.671N>T | p.Thr224Ile | p.T224I | Q32M45 | protein_coding | tolerated(1) | benign(0.048) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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