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Gene: ZNF92 |
Gene summary for ZNF92 |
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Gene information | Species | Human | Gene symbol | ZNF92 | Gene ID | 168374 |
Gene name | zinc finger protein 92 | |
Gene Alias | HEL-203 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q03936 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
168374 | ZNF92 | LZE4T | Human | Esophagus | ESCC | 2.13e-05 | 1.49e-01 | 0.0811 |
168374 | ZNF92 | LZE7T | Human | Esophagus | ESCC | 2.31e-03 | 1.33e-01 | 0.0667 |
168374 | ZNF92 | LZE8T | Human | Esophagus | ESCC | 2.34e-03 | 8.91e-02 | 0.067 |
168374 | ZNF92 | LZE20T | Human | Esophagus | ESCC | 9.71e-06 | 1.64e-01 | 0.0662 |
168374 | ZNF92 | LZE24T | Human | Esophagus | ESCC | 2.34e-10 | 2.28e-01 | 0.0596 |
168374 | ZNF92 | P1T-E | Human | Esophagus | ESCC | 1.98e-02 | 2.34e-01 | 0.0875 |
168374 | ZNF92 | P2T-E | Human | Esophagus | ESCC | 6.39e-21 | 4.08e-01 | 0.1177 |
168374 | ZNF92 | P4T-E | Human | Esophagus | ESCC | 1.17e-10 | 2.60e-01 | 0.1323 |
168374 | ZNF92 | P5T-E | Human | Esophagus | ESCC | 1.35e-05 | 9.92e-02 | 0.1327 |
168374 | ZNF92 | P8T-E | Human | Esophagus | ESCC | 6.04e-12 | 2.61e-01 | 0.0889 |
168374 | ZNF92 | P9T-E | Human | Esophagus | ESCC | 2.63e-09 | 1.25e-01 | 0.1131 |
168374 | ZNF92 | P10T-E | Human | Esophagus | ESCC | 6.54e-16 | 3.52e-01 | 0.116 |
168374 | ZNF92 | P11T-E | Human | Esophagus | ESCC | 4.13e-11 | 5.30e-01 | 0.1426 |
168374 | ZNF92 | P12T-E | Human | Esophagus | ESCC | 1.51e-16 | 3.78e-01 | 0.1122 |
168374 | ZNF92 | P15T-E | Human | Esophagus | ESCC | 2.93e-19 | 3.07e-01 | 0.1149 |
168374 | ZNF92 | P16T-E | Human | Esophagus | ESCC | 6.57e-13 | 3.16e-01 | 0.1153 |
168374 | ZNF92 | P17T-E | Human | Esophagus | ESCC | 1.29e-03 | 2.10e-01 | 0.1278 |
168374 | ZNF92 | P20T-E | Human | Esophagus | ESCC | 3.03e-09 | 1.77e-01 | 0.1124 |
168374 | ZNF92 | P21T-E | Human | Esophagus | ESCC | 5.57e-04 | 9.99e-02 | 0.1617 |
168374 | ZNF92 | P22T-E | Human | Esophagus | ESCC | 2.15e-16 | 2.40e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF92 | SNV | Missense_Mutation | c.1166N>T | p.Arg389Ile | p.R389I | Q03936 | protein_coding | tolerated(0.47) | benign(0.012) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF92 | SNV | Missense_Mutation | c.1602G>T | p.Glu534Asp | p.E534D | Q03936 | protein_coding | deleterious(0.05) | benign(0.325) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF92 | SNV | Missense_Mutation | c.295N>T | p.Ile99Leu | p.I99L | Q03936 | protein_coding | tolerated(0.08) | benign(0.026) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD | |
ZNF92 | insertion | Frame_Shift_Ins | novel | c.990dupA | p.His331ThrfsTer2 | p.H331Tfs*2 | Q03936 | protein_coding | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ZNF92 | SNV | Missense_Mutation | novel | c.577A>C | p.Lys193Gln | p.K193Q | Q03936 | protein_coding | tolerated(0.1) | benign(0.374) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | novel | c.118C>A | p.Leu40Met | p.L40M | Q03936 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | novel | c.1624T>C | p.Cys542Arg | p.C542R | Q03936 | protein_coding | deleterious(0.01) | probably_damaging(0.953) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | novel | c.406T>G | p.Cys136Gly | p.C136G | Q03936 | protein_coding | deleterious(0.01) | possibly_damaging(0.613) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | novel | c.914G>T | p.Arg305Ile | p.R305I | Q03936 | protein_coding | tolerated(0.57) | benign(0.012) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF92 | SNV | Missense_Mutation | c.830G>T | p.Arg277Ile | p.R277I | Q03936 | protein_coding | tolerated(0.62) | benign(0.012) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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