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Gene: ZNF804A |
Gene summary for ZNF804A |
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Gene information | Species | Human | Gene symbol | ZNF804A | Gene ID | 91752 |
Gene name | zinc finger protein 804A | |
Gene Alias | C2orf10 | |
Cytomap | 2q32.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q7Z570 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91752 | ZNF804A | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.00e-03 | 1.58e-01 | -0.0811 |
91752 | ZNF804A | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.30e-17 | 9.15e-01 | 0.0131 |
91752 | ZNF804A | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.64e-05 | 4.38e-01 | 0.0171 |
91752 | ZNF804A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.07e-04 | 1.20e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0106027 | Colorectum | AD | neuron projection organization | 36/3918 | 93/18723 | 6.58e-05 | 1.07e-03 | 36 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0043954 | Colorectum | AD | cellular component maintenance | 26/3918 | 61/18723 | 1.04e-04 | 1.56e-03 | 26 |
GO:0097061 | Colorectum | AD | dendritic spine organization | 31/3918 | 84/18723 | 5.48e-04 | 5.83e-03 | 31 |
GO:0099173 | Colorectum | AD | postsynapse organization | 51/3918 | 168/18723 | 2.47e-03 | 1.90e-02 | 51 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:0050807 | Colorectum | AD | regulation of synapse organization | 60/3918 | 211/18723 | 5.67e-03 | 3.64e-02 | 60 |
GO:0097062 | Colorectum | AD | dendritic spine maintenance | 10/3918 | 21/18723 | 5.71e-03 | 3.64e-02 | 10 |
GO:01060271 | Colorectum | SER | neuron projection organization | 33/2897 | 93/18723 | 1.64e-06 | 7.23e-05 | 33 |
GO:00970611 | Colorectum | SER | dendritic spine organization | 29/2897 | 84/18723 | 1.27e-05 | 4.01e-04 | 29 |
GO:00991731 | Colorectum | SER | postsynapse organization | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00439541 | Colorectum | SER | cellular component maintenance | 22/2897 | 61/18723 | 6.47e-05 | 1.49e-03 | 22 |
GO:00109751 | Colorectum | SER | regulation of neuron projection development | 92/2897 | 445/18723 | 1.85e-03 | 1.89e-02 | 92 |
GO:00313461 | Colorectum | SER | positive regulation of cell projection organization | 75/2897 | 353/18723 | 2.22e-03 | 2.14e-02 | 75 |
GO:00970621 | Colorectum | SER | dendritic spine maintenance | 9/2897 | 21/18723 | 2.50e-03 | 2.33e-02 | 9 |
GO:00508081 | Colorectum | SER | synapse organization | 85/2897 | 426/18723 | 7.17e-03 | 4.99e-02 | 85 |
GO:01060272 | Colorectum | MSS | neuron projection organization | 34/3467 | 93/18723 | 3.04e-05 | 6.14e-04 | 34 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF804A | SNV | Missense_Mutation | rs767120954 | c.3526N>A | p.Val1176Ile | p.V1176I | Q7Z570 | protein_coding | deleterious(0.02) | possibly_damaging(0.833) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF804A | SNV | Missense_Mutation | c.1112C>A | p.Ser371Tyr | p.S371Y | Q7Z570 | protein_coding | deleterious(0.01) | benign(0.401) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF804A | SNV | Missense_Mutation | rs775434371 | c.1675G>A | p.Glu559Lys | p.E559K | Q7Z570 | protein_coding | tolerated(0.37) | benign(0.001) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF804A | SNV | Missense_Mutation | rs143591848 | c.3218N>T | p.Ala1073Val | p.A1073V | Q7Z570 | protein_coding | tolerated(0.11) | possibly_damaging(0.521) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZNF804A | SNV | Missense_Mutation | c.3117A>T | p.Glu1039Asp | p.E1039D | Q7Z570 | protein_coding | tolerated(0.43) | benign(0.092) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF804A | SNV | Missense_Mutation | novel | c.2620N>G | p.Gln874Glu | p.Q874E | Q7Z570 | protein_coding | tolerated(0.25) | benign(0) | TCGA-AA-3866-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF804A | SNV | Missense_Mutation | c.2920N>A | p.Glu974Lys | p.E974K | Q7Z570 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF804A | SNV | Missense_Mutation | c.910G>T | p.Asp304Tyr | p.D304Y | Q7Z570 | protein_coding | deleterious(0) | possibly_damaging(0.72) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF804A | SNV | Missense_Mutation | c.1444N>T | p.Asp482Tyr | p.D482Y | Q7Z570 | protein_coding | tolerated(0.94) | benign(0.24) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF804A | SNV | Missense_Mutation | c.1139T>A | p.Val380Asp | p.V380D | Q7Z570 | protein_coding | tolerated(0.66) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
91752 | ZNF804A | NA | antipsychotics | 21892778 | ||
91752 | ZNF804A | NA | lithium | LITHIUM | 29121268 |
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