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Gene: ZNF730 |
Gene summary for ZNF730 |
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Gene information | Species | Human | Gene symbol | ZNF730 | Gene ID | 100129543 |
Gene name | zinc finger protein 730 | |
Gene Alias | ZNF730 | |
Cytomap | 19p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZMV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100129543 | ZNF730 | HTA11_4255_2000001011 | Human | Colorectum | SER | 8.80e-11 | 7.52e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF730 | SNV | Missense_Mutation | c.1172N>G | p.Thr391Ser | p.T391S | Q6ZMV8 | protein_coding | tolerated(0.15) | benign(0.115) | TCGA-AF-5654-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF730 | SNV | Missense_Mutation | rs751114658 | c.743G>A | p.Arg248Lys | p.R248K | Q6ZMV8 | protein_coding | tolerated(0.48) | benign(0.027) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | novel | c.971N>A | p.Ser324Tyr | p.S324Y | Q6ZMV8 | protein_coding | tolerated(0.29) | probably_damaging(0.937) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | novel | c.1334N>G | p.Ile445Ser | p.I445S | Q6ZMV8 | protein_coding | deleterious(0.02) | possibly_damaging(0.907) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | novel | c.587N>T | p.Thr196Ile | p.T196I | Q6ZMV8 | protein_coding | tolerated(0.2) | benign(0.019) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
ZNF730 | SNV | Missense_Mutation | rs774218595 | c.1331G>T | p.Arg444Ile | p.R444I | Q6ZMV8 | protein_coding | tolerated(0.54) | benign(0.006) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | rs766102868 | c.8N>T | p.Ala3Val | p.A3V | Q6ZMV8 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF730 | SNV | Missense_Mutation | c.99N>A | p.Met33Ile | p.M33I | Q6ZMV8 | protein_coding | deleterious(0.03) | benign(0.354) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF730 | SNV | Missense_Mutation | novel | c.236C>A | p.Ser79Tyr | p.S79Y | Q6ZMV8 | protein_coding | deleterious(0.04) | benign(0.08) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZNF730 | SNV | Missense_Mutation | novel | c.1463C>T | p.Ala488Val | p.A488V | Q6ZMV8 | protein_coding | deleterious(0.05) | probably_damaging(0.984) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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