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Gene: ZNF713 |
Gene summary for ZNF713 |
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Gene information | Species | Human | Gene symbol | ZNF713 | Gene ID | 349075 |
Gene name | zinc finger protein 713 | |
Gene Alias | ZNF713 | |
Cytomap | 7p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0M3HEQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
349075 | ZNF713 | HCC1 | Human | Liver | HCC | 2.23e-14 | 2.63e+00 | 0.5336 |
349075 | ZNF713 | HCC2 | Human | Liver | HCC | 4.76e-25 | 2.29e+00 | 0.5341 |
349075 | ZNF713 | HCC5 | Human | Liver | HCC | 1.98e-24 | 1.49e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF713 | SNV | Missense_Mutation | novel | c.1085G>T | p.Arg362Ile | p.R362I | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF713 | SNV | Missense_Mutation | rs371670199 | c.1304G>A | p.Arg435His | p.R435H | protein_coding | tolerated(0.1) | possibly_damaging(0.498) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF713 | SNV | Missense_Mutation | c.917G>T | p.Arg306Ile | p.R306I | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF713 | SNV | Missense_Mutation | c.483N>T | p.Lys161Asn | p.K161N | protein_coding | tolerated(0.12) | benign(0.005) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF713 | SNV | Missense_Mutation | c.473A>G | p.Glu158Gly | p.E158G | protein_coding | tolerated(0.41) | benign(0.108) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF713 | SNV | Missense_Mutation | rs755851627 | c.1057N>T | p.Arg353Cys | p.R353C | protein_coding | deleterious(0) | benign(0.069) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF713 | SNV | Missense_Mutation | novel | c.486N>C | p.Arg162Ser | p.R162S | protein_coding | tolerated(0.09) | benign(0.382) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF713 | SNV | Missense_Mutation | rs770655285 | c.1111G>A | p.Glu371Lys | p.E371K | protein_coding | tolerated(0.43) | benign(0.285) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF713 | SNV | Missense_Mutation | c.1229N>A | p.Ser410Asn | p.S410N | protein_coding | tolerated(0.34) | probably_damaging(0.948) | TCGA-BG-A0YV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ZNF713 | SNV | Missense_Mutation | rs367652775 | c.1303N>T | p.Arg435Cys | p.R435C | protein_coding | deleterious(0.02) | possibly_damaging(0.498) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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