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Gene: ZNF668 |
Gene summary for ZNF668 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF668 | Gene ID | 79759 |
Gene name | zinc finger protein 668 | |
Gene Alias | ZNF668 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024QZD9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79759 | ZNF668 | LZE4T | Human | Esophagus | ESCC | 1.64e-04 | 1.16e-01 | 0.0811 |
79759 | ZNF668 | LZE24T | Human | Esophagus | ESCC | 4.70e-08 | 2.50e-01 | 0.0596 |
79759 | ZNF668 | P1T-E | Human | Esophagus | ESCC | 4.54e-04 | 1.69e-01 | 0.0875 |
79759 | ZNF668 | P2T-E | Human | Esophagus | ESCC | 4.44e-27 | 3.29e-01 | 0.1177 |
79759 | ZNF668 | P4T-E | Human | Esophagus | ESCC | 9.25e-14 | 2.07e-01 | 0.1323 |
79759 | ZNF668 | P5T-E | Human | Esophagus | ESCC | 2.35e-09 | 1.25e-01 | 0.1327 |
79759 | ZNF668 | P8T-E | Human | Esophagus | ESCC | 1.16e-16 | 1.47e-01 | 0.0889 |
79759 | ZNF668 | P9T-E | Human | Esophagus | ESCC | 8.37e-07 | 1.54e-01 | 0.1131 |
79759 | ZNF668 | P10T-E | Human | Esophagus | ESCC | 6.13e-20 | 1.41e-01 | 0.116 |
79759 | ZNF668 | P11T-E | Human | Esophagus | ESCC | 2.08e-09 | 3.07e-01 | 0.1426 |
79759 | ZNF668 | P12T-E | Human | Esophagus | ESCC | 2.44e-17 | 2.60e-01 | 0.1122 |
79759 | ZNF668 | P15T-E | Human | Esophagus | ESCC | 7.56e-07 | 1.82e-01 | 0.1149 |
79759 | ZNF668 | P16T-E | Human | Esophagus | ESCC | 6.05e-13 | 1.74e-01 | 0.1153 |
79759 | ZNF668 | P20T-E | Human | Esophagus | ESCC | 4.10e-11 | 1.75e-01 | 0.1124 |
79759 | ZNF668 | P21T-E | Human | Esophagus | ESCC | 3.53e-11 | 1.58e-01 | 0.1617 |
79759 | ZNF668 | P22T-E | Human | Esophagus | ESCC | 1.83e-13 | 1.50e-01 | 0.1236 |
79759 | ZNF668 | P23T-E | Human | Esophagus | ESCC | 1.23e-07 | 1.99e-01 | 0.108 |
79759 | ZNF668 | P24T-E | Human | Esophagus | ESCC | 2.25e-14 | 1.51e-01 | 0.1287 |
79759 | ZNF668 | P26T-E | Human | Esophagus | ESCC | 1.28e-18 | 2.23e-01 | 0.1276 |
79759 | ZNF668 | P27T-E | Human | Esophagus | ESCC | 1.25e-14 | 1.90e-01 | 0.1055 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF668 | SNV | Missense_Mutation | c.1778N>A | p.Arg593His | p.R593H | Q96K58 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF668 | SNV | Missense_Mutation | c.809C>T | p.Ala270Val | p.A270V | Q96K58 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF668 | SNV | Missense_Mutation | c.1420G>A | p.Gly474Arg | p.G474R | Q96K58 | protein_coding | tolerated(0.45) | benign(0.12) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF668 | SNV | Missense_Mutation | c.1198G>C | p.Ala400Pro | p.A400P | Q96K58 | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF668 | SNV | Missense_Mutation | rs553159663 | c.925G>A | p.Gly309Ser | p.G309S | Q96K58 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF668 | SNV | Missense_Mutation | c.715C>T | p.Arg239Trp | p.R239W | Q96K58 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF668 | SNV | Missense_Mutation | rs199894608 | c.1625N>A | p.Arg542Gln | p.R542Q | Q96K58 | protein_coding | tolerated(0.55) | possibly_damaging(0.585) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
ZNF668 | SNV | Missense_Mutation | novel | c.1615N>C | p.Phe539Leu | p.F539L | Q96K58 | protein_coding | tolerated(0.25) | benign(0.15) | TCGA-AH-6644-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZNF668 | SNV | Missense_Mutation | novel | c.716N>A | p.Arg239Gln | p.R239Q | Q96K58 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF668 | SNV | Missense_Mutation | c.1154N>A | p.Arg385Gln | p.R385Q | Q96K58 | protein_coding | tolerated(0.06) | possibly_damaging(0.712) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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