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Gene: ZNF662 |
Gene summary for ZNF662 |
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Gene information | Species | Human | Gene symbol | ZNF662 | Gene ID | 389114 |
Gene name | zinc finger protein 662 | |
Gene Alias | ZNF662 | |
Cytomap | 3p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZS27 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389114 | ZNF662 | HCC1 | Human | Liver | HCC | 2.20e-11 | 1.32e+00 | 0.5336 |
389114 | ZNF662 | HCC2 | Human | Liver | HCC | 3.44e-15 | 1.83e+00 | 0.5341 |
389114 | ZNF662 | HCC5 | Human | Liver | HCC | 2.00e-12 | 1.45e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF662 | SNV | Missense_Mutation | novel | c.580N>A | p.Glu194Lys | p.E194K | Q6ZS27 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZNF662 | SNV | Missense_Mutation | c.358G>T | p.Asp120Tyr | p.D120Y | Q6ZS27 | protein_coding | deleterious(0) | benign(0.015) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF662 | SNV | Missense_Mutation | c.1217G>A | p.Arg406Lys | p.R406K | Q6ZS27 | protein_coding | deleterious(0.04) | probably_damaging(0.986) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF662 | SNV | Missense_Mutation | novel | c.898N>G | p.Lys300Glu | p.K300E | Q6ZS27 | protein_coding | deleterious(0) | possibly_damaging(0.906) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | rs763488420 | c.136N>A | p.Glu46Lys | p.E46K | Q6ZS27 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | rs760232360 | c.1075N>A | p.Glu359Lys | p.E359K | Q6ZS27 | protein_coding | tolerated(0.13) | possibly_damaging(0.467) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF662 | SNV | Missense_Mutation | c.358G>T | p.Asp120Tyr | p.D120Y | Q6ZS27 | protein_coding | deleterious(0) | benign(0.015) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | c.1322C>A | p.Pro441His | p.P441H | Q6ZS27 | protein_coding | deleterious(0) | possibly_damaging(0.775) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | c.585N>G | p.Ser195Arg | p.S195R | Q6ZS27 | protein_coding | tolerated(0.63) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF662 | SNV | Missense_Mutation | c.108N>T | p.Glu36Asp | p.E36D | Q6ZS27 | protein_coding | tolerated(0.06) | benign(0.263) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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