![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF654 |
Gene summary for ZNF654 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF654 | Gene ID | 55279 |
Gene name | zinc finger protein 654 | |
Gene Alias | ZNF654 | |
Cytomap | 3p11.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | NA |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55279 | ZNF654 | CCI_1 | Human | Cervix | CC | 3.32e-02 | 4.88e-01 | 0.528 |
55279 | ZNF654 | CCI_2 | Human | Cervix | CC | 3.11e-09 | 1.04e+00 | 0.5249 |
55279 | ZNF654 | CCI_3 | Human | Cervix | CC | 1.67e-07 | 6.67e-01 | 0.516 |
55279 | ZNF654 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.98e-17 | -5.25e-01 | 0.0155 |
55279 | ZNF654 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.89e-08 | -5.10e-01 | -0.1808 |
55279 | ZNF654 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.20e-07 | -4.91e-01 | -0.0811 |
55279 | ZNF654 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.48e-07 | -4.88e-01 | -0.1088 |
55279 | ZNF654 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.01e-15 | -5.05e-01 | -0.1954 |
55279 | ZNF654 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.08e-05 | -5.05e-01 | -0.1207 |
55279 | ZNF654 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.63e-04 | -5.15e-01 | -0.1526 |
55279 | ZNF654 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.44e-22 | -5.17e-01 | -0.1464 |
55279 | ZNF654 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.05e-23 | -5.03e-01 | -0.1001 |
55279 | ZNF654 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.30e-12 | -5.16e-01 | -0.059 |
55279 | ZNF654 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.88e-02 | -5.30e-01 | -0.1706 |
55279 | ZNF654 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.65e-03 | -5.13e-01 | -0.0842 |
55279 | ZNF654 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.35e-04 | -5.30e-01 | -0.0179 |
55279 | ZNF654 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.24e-12 | -5.05e-01 | 0.096 |
55279 | ZNF654 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.03e-03 | -5.30e-01 | 0.0528 |
55279 | ZNF654 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.79e-04 | -5.30e-01 | -0.0177 |
55279 | ZNF654 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.15e-10 | -5.30e-01 | 0.0338 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF654 | SNV | Missense_Mutation | c.505N>C | p.Asp169His | p.D169H | Q8IZM8 | protein_coding | deleterious(0.03) | possibly_damaging(0.888) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
ZNF654 | SNV | Missense_Mutation | c.1067N>C | p.Asn356Thr | p.N356T | Q8IZM8 | protein_coding | deleterious(0.02) | benign(0.054) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF654 | SNV | Missense_Mutation | novel | c.256N>G | p.Ser86Ala | p.S86A | Q8IZM8 | protein_coding | tolerated(0.11) | benign(0.027) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | novel | c.782N>A | p.Arg261Lys | p.R261K | Q8IZM8 | protein_coding | tolerated(0.11) | possibly_damaging(0.874) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | novel | c.386N>C | p.Val129Ala | p.V129A | Q8IZM8 | protein_coding | tolerated(0.56) | benign(0.01) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | c.635N>T | p.Arg212Ile | p.R212I | Q8IZM8 | protein_coding | deleterious(0) | benign(0.278) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF654 | SNV | Missense_Mutation | novel | c.623N>A | p.Arg208Gln | p.R208Q | Q8IZM8 | protein_coding | deleterious(0) | probably_damaging(0.919) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | novel | c.367N>T | p.Asp123Tyr | p.D123Y | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF654 | SNV | Missense_Mutation | novel | c.782N>T | p.Arg261Ile | p.R261I | Q8IZM8 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF654 | SNV | Missense_Mutation | c.979N>T | p.Pro327Ser | p.P327S | Q8IZM8 | protein_coding | tolerated(0.18) | benign(0.131) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |