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Gene: ZNF611 |
Gene summary for ZNF611 |
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Gene information | Species | Human | Gene symbol | ZNF611 | Gene ID | 81856 |
Gene name | zinc finger protein 611 | |
Gene Alias | ZNF611 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N823 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81856 | ZNF611 | RNA-P17T-P17T-2 | Human | Lung | IAC | 4.46e-03 | 7.83e-01 | 0.3371 |
81856 | ZNF611 | RNA-P17T-P17T-8 | Human | Lung | IAC | 9.91e-03 | 6.41e-01 | 0.3329 |
81856 | ZNF611 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.48e-08 | 4.01e-01 | -0.0166 |
81856 | ZNF611 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.74e-06 | 3.24e-01 | -0.0132 |
81856 | ZNF611 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.42e-06 | 3.14e-01 | -0.013 |
81856 | ZNF611 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.13e-06 | 3.60e-01 | -0.0121 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF611 | SNV | Missense_Mutation | novel | c.2037N>C | p.Lys679Asn | p.K679N | Q8N823 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-VS-A9UZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF611 | SNV | Missense_Mutation | rs750624146 | c.159N>A | p.Met53Ile | p.M53I | Q8N823 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-ZJ-A8QO-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF611 | SNV | Missense_Mutation | c.1178N>T | p.Thr393Ile | p.T393I | Q8N823 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF611 | SNV | Missense_Mutation | c.1925G>T | p.Arg642Ile | p.R642I | Q8N823 | protein_coding | tolerated(0.1) | benign(0.034) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF611 | SNV | Missense_Mutation | c.641A>C | p.Asn214Thr | p.N214T | Q8N823 | protein_coding | deleterious(0.04) | benign(0.119) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF611 | SNV | Missense_Mutation | novel | c.588T>G | p.Ile196Met | p.I196M | Q8N823 | protein_coding | deleterious(0.03) | probably_damaging(0.928) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF611 | SNV | Missense_Mutation | c.1660G>T | p.Ala554Ser | p.A554S | Q8N823 | protein_coding | tolerated(0.21) | benign(0.062) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF611 | SNV | Missense_Mutation | novel | c.1253G>T | p.Arg418Ile | p.R418I | Q8N823 | protein_coding | tolerated(0.14) | benign(0.175) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF611 | SNV | Missense_Mutation | c.841N>T | p.His281Tyr | p.H281Y | Q8N823 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF611 | SNV | Missense_Mutation | c.1009N>A | p.Asp337Asn | p.D337N | Q8N823 | protein_coding | deleterious(0) | benign(0) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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