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Gene: ZNF600 |
Gene summary for ZNF600 |
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Gene information | Species | Human | Gene symbol | ZNF600 | Gene ID | 162966 |
Gene name | zinc finger protein 600 | |
Gene Alias | KR-ZNF1 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZNG1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162966 | ZNF600 | LZE20T | Human | Esophagus | ESCC | 1.67e-05 | 1.71e-01 | 0.0662 |
162966 | ZNF600 | LZE24T | Human | Esophagus | ESCC | 1.77e-12 | 3.73e-01 | 0.0596 |
162966 | ZNF600 | P1T-E | Human | Esophagus | ESCC | 3.84e-03 | 3.17e-01 | 0.0875 |
162966 | ZNF600 | P2T-E | Human | Esophagus | ESCC | 1.36e-17 | 1.49e-01 | 0.1177 |
162966 | ZNF600 | P4T-E | Human | Esophagus | ESCC | 6.18e-15 | 3.61e-01 | 0.1323 |
162966 | ZNF600 | P5T-E | Human | Esophagus | ESCC | 4.70e-10 | 2.22e-01 | 0.1327 |
162966 | ZNF600 | P8T-E | Human | Esophagus | ESCC | 2.23e-17 | 2.94e-01 | 0.0889 |
162966 | ZNF600 | P10T-E | Human | Esophagus | ESCC | 1.87e-20 | 2.45e-01 | 0.116 |
162966 | ZNF600 | P11T-E | Human | Esophagus | ESCC | 1.44e-06 | 3.14e-01 | 0.1426 |
162966 | ZNF600 | P12T-E | Human | Esophagus | ESCC | 5.34e-15 | 3.26e-01 | 0.1122 |
162966 | ZNF600 | P16T-E | Human | Esophagus | ESCC | 9.76e-07 | 5.82e-02 | 0.1153 |
162966 | ZNF600 | P17T-E | Human | Esophagus | ESCC | 2.91e-07 | 2.51e-01 | 0.1278 |
162966 | ZNF600 | P20T-E | Human | Esophagus | ESCC | 1.25e-03 | 8.56e-02 | 0.1124 |
162966 | ZNF600 | P21T-E | Human | Esophagus | ESCC | 8.04e-16 | 3.27e-01 | 0.1617 |
162966 | ZNF600 | P22T-E | Human | Esophagus | ESCC | 1.00e-22 | 2.24e-01 | 0.1236 |
162966 | ZNF600 | P24T-E | Human | Esophagus | ESCC | 1.10e-10 | 1.11e-01 | 0.1287 |
162966 | ZNF600 | P26T-E | Human | Esophagus | ESCC | 9.48e-20 | 3.64e-01 | 0.1276 |
162966 | ZNF600 | P27T-E | Human | Esophagus | ESCC | 2.85e-25 | 3.58e-01 | 0.1055 |
162966 | ZNF600 | P28T-E | Human | Esophagus | ESCC | 2.70e-09 | 1.94e-01 | 0.1149 |
162966 | ZNF600 | P30T-E | Human | Esophagus | ESCC | 2.96e-15 | 5.83e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF600 | SNV | Missense_Mutation | novel | c.169N>A | p.Glu57Lys | p.E57K | Q6ZNG1 | protein_coding | tolerated(0.62) | benign(0.074) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF600 | SNV | Missense_Mutation | rs762309221 | c.306G>T | p.Gln102His | p.Q102H | Q6ZNG1 | protein_coding | tolerated(0.17) | probably_damaging(0.948) | TCGA-A6-6140-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | SD |
ZNF600 | SNV | Missense_Mutation | c.859T>G | p.Ser287Ala | p.S287A | Q6ZNG1 | protein_coding | tolerated(0.08) | possibly_damaging(0.746) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF600 | SNV | Missense_Mutation | c.1401G>T | p.Glu467Asp | p.E467D | Q6ZNG1 | protein_coding | deleterious(0.02) | probably_damaging(0.949) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF600 | SNV | Missense_Mutation | rs745558368 | c.965G>T | p.Arg322Ile | p.R322I | Q6ZNG1 | protein_coding | tolerated(0.16) | possibly_damaging(0.665) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF600 | SNV | Missense_Mutation | novel | c.1091G>T | p.Gly364Val | p.G364V | Q6ZNG1 | protein_coding | deleterious(0) | possibly_damaging(0.613) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF600 | SNV | Missense_Mutation | c.881G>T | p.Arg294Ile | p.R294I | Q6ZNG1 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF600 | SNV | Missense_Mutation | c.1973G>T | p.Arg658Ile | p.R658I | Q6ZNG1 | protein_coding | tolerated(0.13) | possibly_damaging(0.566) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF600 | SNV | Missense_Mutation | rs146646314 | c.496G>A | p.Glu166Lys | p.E166K | Q6ZNG1 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF600 | SNV | Missense_Mutation | c.1525C>G | p.Leu509Val | p.L509V | Q6ZNG1 | protein_coding | tolerated(0.74) | benign(0.069) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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