![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF581 |
Gene summary for ZNF581 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF581 | Gene ID | 51545 |
Gene name | zinc finger protein 581 | |
Gene Alias | HSPC189 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9P0T4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51545 | ZNF581 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.84e-06 | 1.39e-01 | 0.0155 |
51545 | ZNF581 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.87e-02 | 1.35e-01 | -0.1808 |
51545 | ZNF581 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.49e-04 | 1.63e-01 | -0.0811 |
51545 | ZNF581 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.95e-04 | 1.27e-01 | -0.1954 |
51545 | ZNF581 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.71e-03 | 2.44e-01 | -0.2196 |
51545 | ZNF581 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.05e-06 | 1.63e-01 | -0.1464 |
51545 | ZNF581 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.13e-03 | 1.19e-01 | -0.1001 |
51545 | ZNF581 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.65e-10 | 2.56e-01 | -0.059 |
51545 | ZNF581 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.05e-12 | 2.77e-01 | 0.096 |
51545 | ZNF581 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.32e-08 | 5.56e-01 | 0.0451 |
51545 | ZNF581 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.19e-02 | 1.83e-01 | 0.0528 |
51545 | ZNF581 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.36e-03 | 1.87e-01 | -0.0177 |
51545 | ZNF581 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.48e-11 | 3.20e-01 | 0.0338 |
51545 | ZNF581 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.21e-31 | 5.96e-01 | 0.0674 |
51545 | ZNF581 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.13e-05 | 2.56e-01 | 0.0112 |
51545 | ZNF581 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.11e-14 | 2.80e-01 | 0.294 |
51545 | ZNF581 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.23e-23 | 4.08e-01 | 0.3859 |
51545 | ZNF581 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.92e-03 | 1.84e-01 | 0.2585 |
51545 | ZNF581 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.10e-17 | 3.50e-01 | 0.3005 |
51545 | ZNF581 | LZE4T | Human | Esophagus | ESCC | 6.73e-13 | 3.42e-01 | 0.0811 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF581 | SNV | Missense_Mutation | c.77N>A | p.Arg26Gln | p.R26Q | Q9P0T4 | protein_coding | tolerated(0.08) | benign(0.009) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF581 | SNV | Missense_Mutation | c.512N>A | p.Arg171His | p.R171H | Q9P0T4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD | |
ZNF581 | SNV | Missense_Mutation | novel | c.316A>T | p.Ser106Cys | p.S106C | Q9P0T4 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-CC-A5UD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ZNF581 | SNV | Missense_Mutation | novel | c.256N>C | p.Cys86Arg | p.C86R | Q9P0T4 | protein_coding | tolerated(0.35) | possibly_damaging(0.521) | TCGA-DD-AAVZ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF581 | SNV | Missense_Mutation | novel | c.97N>T | p.Pro33Ser | p.P33S | Q9P0T4 | protein_coding | tolerated(0.13) | possibly_damaging(0.862) | TCGA-71-8520-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF581 | SNV | Missense_Mutation | c.501N>G | p.His167Gln | p.H167Q | Q9P0T4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4TE-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF581 | SNV | Missense_Mutation | rs747956283 | c.86N>A | p.Arg29His | p.R29H | Q9P0T4 | protein_coding | deleterious(0.03) | benign(0.03) | TCGA-22-4596-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF581 | SNV | Missense_Mutation | novel | c.454N>T | p.Arg152Cys | p.R152C | Q9P0T4 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-43-A474-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
ZNF581 | SNV | Missense_Mutation | novel | c.582G>C | p.Trp194Cys | p.W194C | Q9P0T4 | protein_coding | deleterious(0.03) | possibly_damaging(0.818) | TCGA-98-A538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF581 | SNV | Missense_Mutation | c.428N>A | p.Arg143Gln | p.R143Q | Q9P0T4 | protein_coding | deleterious(0.01) | possibly_damaging(0.888) | TCGA-CR-7367-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |