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Gene: ZNF574 |
Gene summary for ZNF574 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF574 | Gene ID | 64763 |
Gene name | zinc finger protein 574 | |
Gene Alias | FP972 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0C4DFM2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64763 | ZNF574 | LZE4T | Human | Esophagus | ESCC | 5.53e-04 | 1.76e-01 | 0.0811 |
64763 | ZNF574 | LZE7T | Human | Esophagus | ESCC | 2.88e-02 | 1.64e-01 | 0.0667 |
64763 | ZNF574 | LZE8T | Human | Esophagus | ESCC | 4.06e-05 | 1.26e-01 | 0.067 |
64763 | ZNF574 | LZE24T | Human | Esophagus | ESCC | 3.77e-11 | 3.53e-01 | 0.0596 |
64763 | ZNF574 | LZE21T | Human | Esophagus | ESCC | 2.21e-03 | 2.36e-01 | 0.0655 |
64763 | ZNF574 | P1T-E | Human | Esophagus | ESCC | 1.12e-06 | 1.92e-01 | 0.0875 |
64763 | ZNF574 | P2T-E | Human | Esophagus | ESCC | 1.01e-19 | 3.43e-01 | 0.1177 |
64763 | ZNF574 | P4T-E | Human | Esophagus | ESCC | 2.09e-09 | 1.62e-01 | 0.1323 |
64763 | ZNF574 | P5T-E | Human | Esophagus | ESCC | 2.92e-17 | 1.73e-01 | 0.1327 |
64763 | ZNF574 | P8T-E | Human | Esophagus | ESCC | 3.43e-20 | 3.10e-01 | 0.0889 |
64763 | ZNF574 | P10T-E | Human | Esophagus | ESCC | 5.76e-15 | 2.03e-01 | 0.116 |
64763 | ZNF574 | P11T-E | Human | Esophagus | ESCC | 1.20e-16 | 7.12e-01 | 0.1426 |
64763 | ZNF574 | P12T-E | Human | Esophagus | ESCC | 1.61e-20 | 3.82e-01 | 0.1122 |
64763 | ZNF574 | P15T-E | Human | Esophagus | ESCC | 6.84e-20 | 4.18e-01 | 0.1149 |
64763 | ZNF574 | P16T-E | Human | Esophagus | ESCC | 1.96e-15 | 2.51e-01 | 0.1153 |
64763 | ZNF574 | P20T-E | Human | Esophagus | ESCC | 3.43e-19 | 4.37e-01 | 0.1124 |
64763 | ZNF574 | P21T-E | Human | Esophagus | ESCC | 6.65e-10 | 2.56e-02 | 0.1617 |
64763 | ZNF574 | P22T-E | Human | Esophagus | ESCC | 3.69e-14 | 1.91e-01 | 0.1236 |
64763 | ZNF574 | P23T-E | Human | Esophagus | ESCC | 2.91e-16 | 4.75e-01 | 0.108 |
64763 | ZNF574 | P24T-E | Human | Esophagus | ESCC | 4.33e-14 | 1.54e-01 | 0.1287 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF574 | SNV | Missense_Mutation | novel | c.2792G>A | p.Arg931His | p.R931H | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF574 | SNV | Missense_Mutation | rs376269644 | c.1105C>T | p.Arg369Cys | p.R369C | protein_coding | deleterious(0.02) | probably_damaging(0.977) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF574 | SNV | Missense_Mutation | novel | c.2279N>A | p.Gly760Asp | p.G760D | protein_coding | tolerated(0.58) | benign(0.229) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF574 | SNV | Missense_Mutation | c.1886N>G | p.Ala629Gly | p.A629G | protein_coding | tolerated(0.46) | benign(0.21) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ZNF574 | SNV | Missense_Mutation | rs780884334 | c.2062C>T | p.Arg688Cys | p.R688C | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF574 | SNV | Missense_Mutation | c.1832N>A | p.Arg611Gln | p.R611Q | protein_coding | deleterious(0.01) | possibly_damaging(0.784) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF574 | SNV | Missense_Mutation | c.802N>A | p.Ala268Thr | p.A268T | protein_coding | tolerated(0.57) | possibly_damaging(0.791) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF574 | SNV | Missense_Mutation | c.1809N>A | p.His603Gln | p.H603Q | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BM-6198-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | SD | ||
ZNF574 | SNV | Missense_Mutation | c.761N>T | p.Ser254Phe | p.S254F | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-CL-5918-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF574 | SNV | Missense_Mutation | rs757760817 | c.2473N>T | p.Arg825Cys | p.R825C | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-CL-5918-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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