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Gene: ZNF570 |
Gene summary for ZNF570 |
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Gene information | Species | Human | Gene symbol | ZNF570 | Gene ID | 148268 |
Gene name | zinc finger protein 570 | |
Gene Alias | ZNF570 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | K7EP39 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148268 | ZNF570 | HCC1_Meng | Human | Liver | HCC | 1.56e-02 | -3.62e-02 | 0.0246 |
148268 | ZNF570 | HCC1 | Human | Liver | HCC | 2.59e-07 | 1.98e+00 | 0.5336 |
148268 | ZNF570 | HCC2 | Human | Liver | HCC | 1.90e-32 | 3.11e+00 | 0.5341 |
148268 | ZNF570 | HCC5 | Human | Liver | HCC | 1.06e-19 | 2.12e+00 | 0.4932 |
148268 | ZNF570 | male-WTA | Human | Thyroid | PTC | 1.64e-04 | 5.55e-02 | 0.1037 |
148268 | ZNF570 | PTC01 | Human | Thyroid | PTC | 3.70e-02 | 9.69e-03 | 0.1899 |
148268 | ZNF570 | PTC06 | Human | Thyroid | PTC | 1.04e-05 | 1.10e-01 | 0.2057 |
148268 | ZNF570 | PTC07 | Human | Thyroid | PTC | 1.15e-03 | 6.11e-02 | 0.2044 |
148268 | ZNF570 | ATC13 | Human | Thyroid | ATC | 5.98e-58 | 8.70e-01 | 0.34 |
148268 | ZNF570 | ATC5 | Human | Thyroid | ATC | 4.67e-51 | 9.42e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF570 | SNV | Missense_Mutation | novel | c.266N>A | p.Ser89Tyr | p.S89Y | protein_coding | deleterious(0.02) | possibly_damaging(0.724) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
ZNF570 | SNV | Missense_Mutation | novel | c.1049N>A | p.Arg350Gln | p.R350Q | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
ZNF570 | SNV | Missense_Mutation | novel | c.1469G>T | p.Arg490Ile | p.R490I | protein_coding | deleterious(0) | possibly_damaging(0.648) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF570 | insertion | Frame_Shift_Ins | rs758109083 | c.765_766insA | p.Asn258LysfsTer6 | p.N258Kfs*6 | protein_coding | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ZNF570 | insertion | Frame_Shift_Ins | rs758109083 | c.773dupA | p.Asn258LysfsTer6 | p.N258Kfs*6 | protein_coding | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
ZNF570 | SNV | Missense_Mutation | novel | c.1121C>T | p.Ala374Val | p.A374V | protein_coding | tolerated(0.41) | benign(0.013) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF570 | SNV | Missense_Mutation | novel | c.1569G>T | p.Glu523Asp | p.E523D | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF570 | SNV | Missense_Mutation | novel | c.269C>T | p.Ser90Phe | p.S90F | protein_coding | deleterious(0.02) | possibly_damaging(0.467) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF570 | SNV | Missense_Mutation | c.758G>T | p.Arg253Ile | p.R253I | protein_coding | deleterious(0.01) | benign(0.213) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF570 | SNV | Missense_Mutation | c.1273N>A | p.Leu425Ile | p.L425I | protein_coding | tolerated(0.49) | probably_damaging(0.989) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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