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Gene: ZNF546 |
Gene summary for ZNF546 |
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Gene information | Species | Human | Gene symbol | ZNF546 | Gene ID | 339327 |
Gene name | zinc finger protein 546 | |
Gene Alias | ZNF49 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KVL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339327 | ZNF546 | PTC07 | Human | Thyroid | PTC | 5.55e-04 | 7.52e-02 | 0.2044 |
339327 | ZNF546 | ATC13 | Human | Thyroid | ATC | 1.65e-35 | 6.03e-01 | 0.34 |
339327 | ZNF546 | ATC5 | Human | Thyroid | ATC | 7.13e-34 | 6.47e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF546 | insertion | Frame_Shift_Ins | novel | c.557_558insTAGTGAAGGTGTTAGGCCTT | p.Glu186AspfsTer8 | p.E186Dfs*8 | Q86UE3 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF546 | insertion | Frame_Shift_Ins | novel | c.1222_1223insTGATTTCT | p.Thr408MetfsTer84 | p.T408Mfs*84 | Q86UE3 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF546 | insertion | Frame_Shift_Ins | novel | c.2510_2511insAGTCGATAACTGCAAAT | p.Ter837%3D | p.*837%3D | Q86UE3 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF546 | SNV | Missense_Mutation | rs373735181 | c.1856N>A | p.Arg619Gln | p.R619Q | Q86UE3 | protein_coding | tolerated(0.17) | possibly_damaging(0.837) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF546 | SNV | Missense_Mutation | rs760099860 | c.2276G>A | p.Arg759His | p.R759H | Q86UE3 | protein_coding | tolerated(0.21) | possibly_damaging(0.886) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
ZNF546 | SNV | Missense_Mutation | c.275N>G | p.Asn92Ser | p.N92S | Q86UE3 | protein_coding | deleterious(0.01) | benign(0.023) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF546 | SNV | Missense_Mutation | c.1408N>C | p.Glu470Gln | p.E470Q | Q86UE3 | protein_coding | tolerated(0.05) | benign(0.023) | TCGA-Q1-A6DW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF546 | SNV | Missense_Mutation | novel | c.1583A>G | p.Asn528Ser | p.N528S | Q86UE3 | protein_coding | tolerated(0.13) | benign(0.018) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF546 | SNV | Missense_Mutation | c.2212N>G | p.Gln738Glu | p.Q738E | Q86UE3 | protein_coding | tolerated(1) | benign(0.03) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
ZNF546 | SNV | Missense_Mutation | c.1384N>G | p.Thr462Ala | p.T462A | Q86UE3 | protein_coding | deleterious(0.02) | benign(0.006) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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