![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF426 |
Gene summary for ZNF426 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF426 | Gene ID | 79088 |
Gene name | zinc finger protein 426 | |
Gene Alias | K-RBP | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | K7ER43 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79088 | ZNF426 | LZE5T | Human | Esophagus | ESCC | 1.57e-02 | 2.08e-01 | 0.0514 |
79088 | ZNF426 | LZE8T | Human | Esophagus | ESCC | 1.10e-02 | 7.76e-02 | 0.067 |
79088 | ZNF426 | LZE20T | Human | Esophagus | ESCC | 7.18e-07 | 2.07e-01 | 0.0662 |
79088 | ZNF426 | LZE24T | Human | Esophagus | ESCC | 2.65e-05 | 1.27e-01 | 0.0596 |
79088 | ZNF426 | LZE21T | Human | Esophagus | ESCC | 1.37e-06 | 3.00e-01 | 0.0655 |
79088 | ZNF426 | P1T-E | Human | Esophagus | ESCC | 1.05e-09 | 3.04e-01 | 0.0875 |
79088 | ZNF426 | P2T-E | Human | Esophagus | ESCC | 2.83e-25 | 4.09e-01 | 0.1177 |
79088 | ZNF426 | P4T-E | Human | Esophagus | ESCC | 5.16e-10 | 1.91e-01 | 0.1323 |
79088 | ZNF426 | P5T-E | Human | Esophagus | ESCC | 1.30e-07 | 1.56e-01 | 0.1327 |
79088 | ZNF426 | P8T-E | Human | Esophagus | ESCC | 1.88e-16 | 3.33e-01 | 0.0889 |
79088 | ZNF426 | P9T-E | Human | Esophagus | ESCC | 2.38e-11 | 2.16e-01 | 0.1131 |
79088 | ZNF426 | P10T-E | Human | Esophagus | ESCC | 8.82e-23 | 3.72e-01 | 0.116 |
79088 | ZNF426 | P11T-E | Human | Esophagus | ESCC | 3.25e-05 | 2.08e-01 | 0.1426 |
79088 | ZNF426 | P12T-E | Human | Esophagus | ESCC | 4.28e-16 | 2.88e-01 | 0.1122 |
79088 | ZNF426 | P15T-E | Human | Esophagus | ESCC | 3.16e-13 | 2.03e-01 | 0.1149 |
79088 | ZNF426 | P16T-E | Human | Esophagus | ESCC | 7.05e-12 | 2.92e-01 | 0.1153 |
79088 | ZNF426 | P17T-E | Human | Esophagus | ESCC | 4.79e-04 | 1.63e-01 | 0.1278 |
79088 | ZNF426 | P20T-E | Human | Esophagus | ESCC | 6.20e-06 | 1.28e-01 | 0.1124 |
79088 | ZNF426 | P21T-E | Human | Esophagus | ESCC | 3.65e-12 | 2.67e-01 | 0.1617 |
79088 | ZNF426 | P24T-E | Human | Esophagus | ESCC | 2.68e-06 | 1.22e-01 | 0.1287 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF426 | SNV | Missense_Mutation | c.65N>G | p.Glu22Gly | p.E22G | Q9BUY5 | protein_coding | deleterious(0.03) | benign(0.031) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF426 | SNV | Missense_Mutation | rs774588233 | c.757N>A | p.Glu253Lys | p.E253K | Q9BUY5 | protein_coding | tolerated(0.3) | benign(0.009) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF426 | SNV | Missense_Mutation | novel | c.506N>A | p.Ser169Asn | p.S169N | Q9BUY5 | protein_coding | tolerated(1) | benign(0.187) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF426 | SNV | Missense_Mutation | rs374330822 | c.136G>A | p.Asp46Asn | p.D46N | Q9BUY5 | protein_coding | deleterious(0.01) | probably_damaging(0.948) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF426 | SNV | Missense_Mutation | rs753272701 | c.862G>T | p.Gly288Cys | p.G288C | Q9BUY5 | protein_coding | tolerated(0.19) | benign(0.009) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF426 | SNV | Missense_Mutation | c.1643G>A | p.Arg548Gln | p.R548Q | Q9BUY5 | protein_coding | tolerated(0.57) | possibly_damaging(0.602) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF426 | SNV | Missense_Mutation | novel | c.115N>G | p.Gln39Glu | p.Q39E | Q9BUY5 | protein_coding | deleterious(0) | benign(0.217) | TCGA-AJ-A3QS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ZNF426 | SNV | Missense_Mutation | c.803C>T | p.Ser268Phe | p.S268F | Q9BUY5 | protein_coding | deleterious(0.01) | benign(0.102) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ZNF426 | SNV | Missense_Mutation | rs755611696 | c.1634G>A | p.Arg545His | p.R545H | Q9BUY5 | protein_coding | tolerated(0.2) | possibly_damaging(0.84) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF426 | SNV | Missense_Mutation | rs35803355 | c.308A>G | p.Gln103Arg | p.Q103R | Q9BUY5 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |