Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ZNF410_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZNF410_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ZNF410_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF410 | PLA | Breast | Healthy | GPRC5A,NPM3,AC092803.2, etc. | 1.05e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
ZNF410 | PLA | Breast | IDC | GPRC5A,NPM3,AC092803.2, etc. | 1.39e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_IDC/regulons_activity_in_dotplot.png) |
ZNF410 | CD8TEXP | Breast | IDC | GPRC5A,NPM3,AC092803.2, etc. | 5.14e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_IDC/regulons_activity_in_dotplot.png) |
ZNF410 | PLA | Breast | Precancer | GPRC5A,NPM3,AC092803.2, etc. | 1.28e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Breast/Str/TF_Precancer/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF410 | SNV | Missense_Mutation | | c.1031G>A | p.Arg344Gln | p.R344Q | Q86VK4 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | novel | c.526G>T | p.Asp176Tyr | p.D176Y | Q86VK4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | novel | c.1131N>T | p.Lys377Asn | p.K377N | Q86VK4 | protein_coding | tolerated(0.05) | benign(0.136) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | rs376404532 | c.286N>T | p.Arg96Trp | p.R96W | Q86VK4 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.513) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | novel | c.969N>T | p.Glu323Asp | p.E323D | Q86VK4 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | | c.1446N>C | p.Gln482His | p.Q482H | Q86VK4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.979) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ZNF410 | SNV | Missense_Mutation | | c.400N>A | p.Asp134Asn | p.D134N | Q86VK4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.986) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
ZNF410 | SNV | Missense_Mutation | novel | c.593N>A | p.Arg198His | p.R198H | Q86VK4 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ZNF410 | SNV | Missense_Mutation | | c.863G>A | p.Arg288Lys | p.R288K | Q86VK4 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF410 | SNV | Missense_Mutation | novel | c.1216G>A | p.Ala406Thr | p.A406T | Q86VK4 | protein_coding | tolerated(0.2) | benign(0.01) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |