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Gene: ZNF318 |
Gene summary for ZNF318 |
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Gene information | Species | Human | Gene symbol | ZNF318 | Gene ID | 24149 |
Gene name | zinc finger protein 318 | |
Gene Alias | HRIHFB2436 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q5VUA4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
24149 | ZNF318 | LZE2T | Human | Esophagus | ESCC | 9.70e-14 | 1.35e+00 | 0.082 |
24149 | ZNF318 | LZE20T | Human | Esophagus | ESCC | 1.27e-02 | 1.33e-01 | 0.0662 |
24149 | ZNF318 | LZE24T | Human | Esophagus | ESCC | 2.10e-05 | 1.49e-01 | 0.0596 |
24149 | ZNF318 | P1T-E | Human | Esophagus | ESCC | 3.51e-02 | 1.80e-01 | 0.0875 |
24149 | ZNF318 | P2T-E | Human | Esophagus | ESCC | 3.54e-30 | 4.48e-01 | 0.1177 |
24149 | ZNF318 | P4T-E | Human | Esophagus | ESCC | 1.46e-06 | 1.41e-01 | 0.1323 |
24149 | ZNF318 | P5T-E | Human | Esophagus | ESCC | 1.36e-04 | 3.75e-02 | 0.1327 |
24149 | ZNF318 | P8T-E | Human | Esophagus | ESCC | 1.46e-06 | 1.24e-01 | 0.0889 |
24149 | ZNF318 | P10T-E | Human | Esophagus | ESCC | 3.34e-08 | 1.28e-01 | 0.116 |
24149 | ZNF318 | P11T-E | Human | Esophagus | ESCC | 2.50e-07 | 2.52e-01 | 0.1426 |
24149 | ZNF318 | P12T-E | Human | Esophagus | ESCC | 8.57e-15 | 3.43e-01 | 0.1122 |
24149 | ZNF318 | P15T-E | Human | Esophagus | ESCC | 2.59e-06 | 1.99e-01 | 0.1149 |
24149 | ZNF318 | P16T-E | Human | Esophagus | ESCC | 2.72e-06 | 1.65e-01 | 0.1153 |
24149 | ZNF318 | P17T-E | Human | Esophagus | ESCC | 6.20e-08 | 3.59e-01 | 0.1278 |
24149 | ZNF318 | P20T-E | Human | Esophagus | ESCC | 2.48e-02 | 5.89e-02 | 0.1124 |
24149 | ZNF318 | P21T-E | Human | Esophagus | ESCC | 4.87e-10 | 1.26e-01 | 0.1617 |
24149 | ZNF318 | P22T-E | Human | Esophagus | ESCC | 6.33e-09 | 1.27e-01 | 0.1236 |
24149 | ZNF318 | P23T-E | Human | Esophagus | ESCC | 2.03e-05 | 1.79e-01 | 0.108 |
24149 | ZNF318 | P24T-E | Human | Esophagus | ESCC | 3.63e-05 | 1.52e-01 | 0.1287 |
24149 | ZNF318 | P26T-E | Human | Esophagus | ESCC | 3.76e-19 | 3.27e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF318 | SNV | Missense_Mutation | c.5287N>C | p.Glu1763Gln | p.E1763Q | Q5VUA4 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.603) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
ZNF318 | SNV | Missense_Mutation | c.2544G>C | p.Gln848His | p.Q848H | Q5VUA4 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF318 | SNV | Missense_Mutation | novel | c.2075N>A | p.Ser692Tyr | p.S692Y | Q5VUA4 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.977) | TCGA-S3-AA15-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ZNF318 | insertion | In_Frame_Ins | novel | c.4360_4361insACACACACACACACACACACACACACA | p.Pro1454delinsHisThrHisThrHisThrHisThrHisThr | p.P1454delinsHTHTHTHTHT | Q5VUA4 | protein_coding | TCGA-A2-A0EP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | ||
ZNF318 | insertion | Frame_Shift_Ins | novel | c.4355_4356insACAAGAGCAAGGAGTTTCAGTTG | p.Pro1453GlnfsTer32 | p.P1453Qfs*32 | Q5VUA4 | protein_coding | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ZNF318 | insertion | In_Frame_Ins | novel | c.4353_4354insGCTATGTGTTTAACAGGTAGT | p.Pro1451_Pro1452insAlaMetCysLeuThrGlySer | p.P1451_P1452insAMCLTGS | Q5VUA4 | protein_coding | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
ZNF318 | insertion | Frame_Shift_Ins | novel | c.3732_3733insTGCTCTTTCACAAAGGCAAAATTAGACTCATTTTTATCAGAAGCTAG | p.Glu1245CysfsTer31 | p.E1245Cfs*31 | Q5VUA4 | protein_coding | TCGA-A8-A0A6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | CR | ||
ZNF318 | insertion | Frame_Shift_Ins | novel | c.2704_2705insTCAGCTACTT | p.Arg902LeufsTer15 | p.R902Lfs*15 | Q5VUA4 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
ZNF318 | insertion | In_Frame_Ins | novel | c.4355_4356insCTT | p.Pro1452_Pro1453insPhe | p.P1452_P1453insF | Q5VUA4 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF318 | insertion | Frame_Shift_Ins | novel | c.870_871insGCTTTTTTTTTCCTTTTCTTTTGGGGATCCATAGAAAAGAAAAC | p.Ser291AlafsTer60 | p.S291Afs*60 | Q5VUA4 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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