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Gene: ZNF280D |
Gene summary for ZNF280D |
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Gene information | Species | Human | Gene symbol | ZNF280D | Gene ID | 54816 |
Gene name | zinc finger protein 280D | |
Gene Alias | SUHW4 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6N043 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54816 | ZNF280D | LZE2T | Human | Esophagus | ESCC | 5.80e-05 | 4.14e-01 | 0.082 |
54816 | ZNF280D | LZE3D | Human | Esophagus | HGIN | 1.76e-02 | 4.34e-01 | 0.0668 |
54816 | ZNF280D | LZE4T | Human | Esophagus | ESCC | 1.94e-18 | 5.33e-01 | 0.0811 |
54816 | ZNF280D | LZE5T | Human | Esophagus | ESCC | 6.03e-08 | 4.63e-01 | 0.0514 |
54816 | ZNF280D | LZE7T | Human | Esophagus | ESCC | 4.18e-14 | 5.12e-01 | 0.0667 |
54816 | ZNF280D | LZE8T | Human | Esophagus | ESCC | 3.74e-09 | 2.34e-01 | 0.067 |
54816 | ZNF280D | LZE20T | Human | Esophagus | ESCC | 3.65e-03 | 1.01e-01 | 0.0662 |
54816 | ZNF280D | LZE22T | Human | Esophagus | ESCC | 4.29e-06 | 2.28e-01 | 0.068 |
54816 | ZNF280D | LZE24T | Human | Esophagus | ESCC | 2.64e-12 | 1.67e-01 | 0.0596 |
54816 | ZNF280D | LZE21T | Human | Esophagus | ESCC | 1.58e-08 | 4.57e-01 | 0.0655 |
54816 | ZNF280D | LZE6T | Human | Esophagus | ESCC | 3.11e-06 | 3.17e-01 | 0.0845 |
54816 | ZNF280D | P1T-E | Human | Esophagus | ESCC | 9.03e-17 | 5.76e-01 | 0.0875 |
54816 | ZNF280D | P2T-E | Human | Esophagus | ESCC | 2.15e-32 | 5.95e-01 | 0.1177 |
54816 | ZNF280D | P4T-E | Human | Esophagus | ESCC | 2.79e-36 | 6.21e-01 | 0.1323 |
54816 | ZNF280D | P5T-E | Human | Esophagus | ESCC | 2.50e-17 | 3.81e-01 | 0.1327 |
54816 | ZNF280D | P8T-E | Human | Esophagus | ESCC | 2.22e-35 | 5.92e-01 | 0.0889 |
54816 | ZNF280D | P9T-E | Human | Esophagus | ESCC | 2.95e-30 | 5.06e-01 | 0.1131 |
54816 | ZNF280D | P10T-E | Human | Esophagus | ESCC | 1.12e-44 | 7.41e-01 | 0.116 |
54816 | ZNF280D | P11T-E | Human | Esophagus | ESCC | 9.65e-23 | 4.75e-01 | 0.1426 |
54816 | ZNF280D | P12T-E | Human | Esophagus | ESCC | 3.96e-42 | 8.26e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF280D | SNV | Missense_Mutation | c.1417G>C | p.Gly473Arg | p.G473R | Q6N043 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-D5-6922-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF280D | SNV | Missense_Mutation | rs769699925 | c.1894N>A | p.Glu632Lys | p.E632K | Q6N043 | protein_coding | tolerated(0.42) | benign(0.079) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF280D | SNV | Missense_Mutation | novel | c.1903N>T | p.Asp635Tyr | p.D635Y | Q6N043 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF280D | SNV | Missense_Mutation | novel | c.1507A>C | p.Lys503Gln | p.K503Q | Q6N043 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ZNF280D | SNV | Missense_Mutation | novel | c.1360A>C | p.Lys454Gln | p.K454Q | Q6N043 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ZNF280D | SNV | Missense_Mutation | novel | c.318A>G | p.Ile106Met | p.I106M | Q6N043 | protein_coding | deleterious(0.02) | benign(0.139) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ZNF280D | SNV | Missense_Mutation | novel | c.2322N>C | p.Gln774His | p.Q774H | Q6N043 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF280D | deletion | Frame_Shift_Del | c.2223delA | p.Glu742LysfsTer62 | p.E742Kfs*62 | Q6N043 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
ZNF280D | deletion | Frame_Shift_Del | c.1354delN | p.Cys452AlafsTer16 | p.C452Afs*16 | Q6N043 | protein_coding | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
ZNF280D | SNV | Missense_Mutation | novel | c.2863N>T | p.Asp955Tyr | p.D955Y | Q6N043 | protein_coding | deleterious(0) | benign(0.233) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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