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Gene: ZNF224 |
Gene summary for ZNF224 |
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Gene information | Species | Human | Gene symbol | ZNF224 | Gene ID | 7767 |
Gene name | zinc finger protein 224 | |
Gene Alias | BMZF-2 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9NZL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7767 | ZNF224 | LZE4T | Human | Esophagus | ESCC | 8.07e-03 | 1.40e-01 | 0.0811 |
7767 | ZNF224 | LZE7T | Human | Esophagus | ESCC | 3.58e-03 | 1.54e-01 | 0.0667 |
7767 | ZNF224 | LZE8T | Human | Esophagus | ESCC | 9.12e-04 | 1.22e-01 | 0.067 |
7767 | ZNF224 | LZE20T | Human | Esophagus | ESCC | 2.17e-02 | 9.65e-02 | 0.0662 |
7767 | ZNF224 | LZE24T | Human | Esophagus | ESCC | 7.83e-09 | 2.23e-01 | 0.0596 |
7767 | ZNF224 | P1T-E | Human | Esophagus | ESCC | 2.15e-05 | 2.90e-01 | 0.0875 |
7767 | ZNF224 | P2T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.90e-01 | 0.1177 |
7767 | ZNF224 | P4T-E | Human | Esophagus | ESCC | 5.31e-06 | 1.67e-01 | 0.1323 |
7767 | ZNF224 | P5T-E | Human | Esophagus | ESCC | 7.90e-03 | 5.39e-02 | 0.1327 |
7767 | ZNF224 | P8T-E | Human | Esophagus | ESCC | 3.41e-42 | 6.84e-01 | 0.0889 |
7767 | ZNF224 | P9T-E | Human | Esophagus | ESCC | 3.99e-02 | 1.06e-01 | 0.1131 |
7767 | ZNF224 | P10T-E | Human | Esophagus | ESCC | 1.15e-45 | 6.33e-01 | 0.116 |
7767 | ZNF224 | P11T-E | Human | Esophagus | ESCC | 1.06e-11 | 3.66e-01 | 0.1426 |
7767 | ZNF224 | P12T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.52e-01 | 0.1122 |
7767 | ZNF224 | P15T-E | Human | Esophagus | ESCC | 5.40e-05 | 1.41e-01 | 0.1149 |
7767 | ZNF224 | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 7.35e-02 | 0.1153 |
7767 | ZNF224 | P17T-E | Human | Esophagus | ESCC | 3.40e-04 | 2.46e-01 | 0.1278 |
7767 | ZNF224 | P20T-E | Human | Esophagus | ESCC | 1.45e-07 | 2.04e-01 | 0.1124 |
7767 | ZNF224 | P21T-E | Human | Esophagus | ESCC | 7.90e-03 | 7.29e-02 | 0.1617 |
7767 | ZNF224 | P22T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.61e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF224 | SNV | Missense_Mutation | novel | c.41N>T | p.Ala14Val | p.A14V | Q9NZL3 | protein_coding | deleterious(0) | benign(0.246) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF224 | SNV | Missense_Mutation | c.1727N>T | p.Arg576Ile | p.R576I | Q9NZL3 | protein_coding | tolerated(0.36) | benign(0.014) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF224 | SNV | Missense_Mutation | rs776722113 | c.2087N>A | p.Arg696Gln | p.R696Q | Q9NZL3 | protein_coding | tolerated(1) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF224 | SNV | Missense_Mutation | rs750326152 | c.1850N>A | p.Arg617His | p.R617H | Q9NZL3 | protein_coding | deleterious(0) | possibly_damaging(0.493) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF224 | SNV | Missense_Mutation | c.1763G>T | p.Arg588Ile | p.R588I | Q9NZL3 | protein_coding | deleterious(0.02) | possibly_damaging(0.755) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
ZNF224 | SNV | Missense_Mutation | rs776722113 | c.2087G>A | p.Arg696Gln | p.R696Q | Q9NZL3 | protein_coding | tolerated(1) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF224 | SNV | Missense_Mutation | c.231N>A | p.Asn77Lys | p.N77K | Q9NZL3 | protein_coding | tolerated(0.39) | possibly_damaging(0.585) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
ZNF224 | SNV | Missense_Mutation | c.346N>T | p.Asp116Tyr | p.D116Y | Q9NZL3 | protein_coding | deleterious(0) | possibly_damaging(0.56) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF224 | SNV | Missense_Mutation | novel | c.671G>C | p.Arg224Thr | p.R224T | Q9NZL3 | protein_coding | deleterious(0.04) | possibly_damaging(0.573) | TCGA-AG-A01N-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | SD |
ZNF224 | SNV | Missense_Mutation | c.1829N>G | p.Thr610Ser | p.T610S | Q9NZL3 | protein_coding | tolerated(0.26) | benign(0.018) | TCGA-CI-6619-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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