![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF182 |
Gene summary for ZNF182 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF182 | Gene ID | 7569 |
Gene name | zinc finger protein 182 | |
Gene Alias | HHZ150 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17025 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7569 | ZNF182 | HCC1_Meng | Human | Liver | HCC | 1.13e-10 | 6.09e-03 | 0.0246 |
7569 | ZNF182 | HCC1 | Human | Liver | HCC | 4.49e-17 | 4.48e+00 | 0.5336 |
7569 | ZNF182 | HCC2 | Human | Liver | HCC | 5.09e-04 | 2.57e+00 | 0.5341 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF182 | SNV | Missense_Mutation | rs371902876 | c.1769N>T | p.Arg590Ile | p.R590I | P17025 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ZNF182 | SNV | Missense_Mutation | novel | c.848N>A | p.Thr283Asn | p.T283N | P17025 | protein_coding | tolerated(0.15) | benign(0.226) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ZNF182 | SNV | Missense_Mutation | rs139634264 | c.845G>A | p.Arg282Gln | p.R282Q | P17025 | protein_coding | deleterious(0.03) | possibly_damaging(0.693) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF182 | SNV | Missense_Mutation | rs782276851 | c.419T>C | p.Phe140Ser | p.F140S | P17025 | protein_coding | deleterious(0.02) | benign(0.263) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF182 | SNV | Missense_Mutation | rs782403540 | c.1349N>T | p.Arg450Ile | p.R450I | P17025 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | rs782624997 | c.796G>A | p.Glu266Lys | p.E266K | P17025 | protein_coding | tolerated(0.07) | benign(0.429) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | c.1145N>G | p.Thr382Ser | p.T382S | P17025 | protein_coding | deleterious(0.03) | possibly_damaging(0.581) | TCGA-EI-6510-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF182 | SNV | Missense_Mutation | rs139634264 | c.845G>A | p.Arg282Gln | p.R282Q | P17025 | protein_coding | deleterious(0.03) | possibly_damaging(0.693) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ZNF182 | SNV | Missense_Mutation | novel | c.1239N>T | p.Glu413Asp | p.E413D | P17025 | protein_coding | tolerated(0.45) | possibly_damaging(0.584) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | rs782624997 | c.796N>A | p.Glu266Lys | p.E266K | P17025 | protein_coding | tolerated(0.07) | benign(0.429) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |