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Gene: ZIC1 |
Gene summary for ZIC1 |
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Gene information | Species | Human | Gene symbol | ZIC1 | Gene ID | 7545 |
Gene name | Zic family member 1 | |
Gene Alias | BAIDCS | |
Cytomap | 3q24 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q15915 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7545 | ZIC1 | LZE4T | Human | Esophagus | ESCC | 8.22e-34 | 7.51e-01 | 0.0811 |
7545 | ZIC1 | LZE8T | Human | Esophagus | ESCC | 5.45e-16 | 4.06e-01 | 0.067 |
7545 | ZIC1 | P1T-E | Human | Esophagus | ESCC | 2.97e-02 | 2.04e-01 | 0.0875 |
7545 | ZIC1 | P5T-E | Human | Esophagus | ESCC | 1.51e-34 | 5.81e-01 | 0.1327 |
7545 | ZIC1 | P10T-E | Human | Esophagus | ESCC | 2.07e-74 | 1.16e+00 | 0.116 |
7545 | ZIC1 | P11T-E | Human | Esophagus | ESCC | 2.05e-22 | 7.06e-01 | 0.1426 |
7545 | ZIC1 | P16T-E | Human | Esophagus | ESCC | 3.90e-42 | 6.96e-01 | 0.1153 |
7545 | ZIC1 | P20T-E | Human | Esophagus | ESCC | 1.38e-55 | 1.01e+00 | 0.1124 |
7545 | ZIC1 | P21T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.12e-01 | 0.1617 |
7545 | ZIC1 | P26T-E | Human | Esophagus | ESCC | 1.59e-30 | 4.82e-01 | 0.1276 |
7545 | ZIC1 | P27T-E | Human | Esophagus | ESCC | 5.12e-47 | 8.17e-01 | 0.1055 |
7545 | ZIC1 | P31T-E | Human | Esophagus | ESCC | 2.49e-44 | 7.64e-01 | 0.1251 |
7545 | ZIC1 | P32T-E | Human | Esophagus | ESCC | 2.08e-40 | 8.01e-01 | 0.1666 |
7545 | ZIC1 | P36T-E | Human | Esophagus | ESCC | 4.85e-17 | 4.73e-01 | 0.1187 |
7545 | ZIC1 | P39T-E | Human | Esophagus | ESCC | 3.87e-34 | 5.75e-01 | 0.0894 |
7545 | ZIC1 | P40T-E | Human | Esophagus | ESCC | 4.43e-16 | 5.23e-01 | 0.109 |
7545 | ZIC1 | P42T-E | Human | Esophagus | ESCC | 4.49e-48 | 1.07e+00 | 0.1175 |
7545 | ZIC1 | P52T-E | Human | Esophagus | ESCC | 9.56e-08 | 2.11e-01 | 0.1555 |
7545 | ZIC1 | P56T-E | Human | Esophagus | ESCC | 5.84e-10 | 1.08e+00 | 0.1613 |
7545 | ZIC1 | P57T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.39e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:1903829111 | Esophagus | ESCC | positive regulation of cellular protein localization | 199/8552 | 276/18723 | 2.99e-19 | 3.45e-17 | 199 |
GO:0033157110 | Esophagus | ESCC | regulation of intracellular protein transport | 169/8552 | 229/18723 | 3.31e-18 | 3.23e-16 | 169 |
GO:0032388110 | Esophagus | ESCC | positive regulation of intracellular transport | 152/8552 | 202/18723 | 7.89e-18 | 7.36e-16 | 152 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0046822110 | Esophagus | ESCC | regulation of nucleocytoplasmic transport | 88/8552 | 106/18723 | 1.88e-15 | 1.19e-13 | 88 |
GO:009031617 | Esophagus | ESCC | positive regulation of intracellular protein transport | 122/8552 | 160/18723 | 2.45e-15 | 1.49e-13 | 122 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:190018018 | Esophagus | ESCC | regulation of protein localization to nucleus | 102/8552 | 136/18723 | 2.84e-12 | 1.13e-10 | 102 |
GO:190018217 | Esophagus | ESCC | positive regulation of protein localization to nucleus | 70/8552 | 87/18723 | 2.63e-11 | 8.99e-10 | 70 |
GO:004682417 | Esophagus | ESCC | positive regulation of nucleocytoplasmic transport | 52/8552 | 62/18723 | 5.40e-10 | 1.38e-08 | 52 |
GO:005117014 | Esophagus | ESCC | import into nucleus | 111/8552 | 159/18723 | 5.69e-10 | 1.44e-08 | 111 |
GO:000660613 | Esophagus | ESCC | protein import into nucleus | 108/8552 | 155/18723 | 1.16e-09 | 2.77e-08 | 108 |
GO:190458914 | Esophagus | ESCC | regulation of protein import | 49/8552 | 63/18723 | 1.91e-07 | 2.97e-06 | 49 |
GO:190459116 | Esophagus | ESCC | positive regulation of protein import | 36/8552 | 43/18723 | 2.90e-07 | 4.20e-06 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZIC1 | SNV | Missense_Mutation | c.1070C>T | p.Thr357Met | p.T357M | Q15915 | protein_coding | deleterious(0) | possibly_damaging(0.757) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZIC1 | SNV | Missense_Mutation | c.569N>A | p.Ala190Asp | p.A190D | Q15915 | protein_coding | deleterious(0.01) | benign(0.075) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZIC1 | SNV | Missense_Mutation | c.943N>T | p.Arg315Cys | p.R315C | Q15915 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-CA-5254-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
ZIC1 | SNV | Missense_Mutation | novel | c.1143N>T | p.Met381Ile | p.M381I | Q15915 | protein_coding | deleterious(0) | benign(0.055) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZIC1 | SNV | Missense_Mutation | rs756221956 | c.1096A>G | p.Met366Val | p.M366V | Q15915 | protein_coding | tolerated(1) | benign(0.023) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZIC1 | SNV | Missense_Mutation | c.535N>A | p.Gly179Ser | p.G179S | Q15915 | protein_coding | tolerated(0.65) | benign(0.015) | TCGA-CM-4748-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
ZIC1 | SNV | Missense_Mutation | novel | c.1273N>C | p.Ser425Pro | p.S425P | Q15915 | protein_coding | tolerated(0.32) | benign(0.031) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
ZIC1 | SNV | Missense_Mutation | c.738N>G | p.Phe246Leu | p.F246L | Q15915 | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR | |
ZIC1 | SNV | Missense_Mutation | c.1112N>G | p.Tyr371Cys | p.Y371C | Q15915 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DY-A1DC-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | capecitabine | PR | |
ZIC1 | SNV | Missense_Mutation | c.836N>G | p.Glu279Gly | p.E279G | Q15915 | protein_coding | deleterious(0.02) | benign(0.107) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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