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Gene: ZBTB44 |
Gene summary for ZBTB44 |
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Gene information | Species | Human | Gene symbol | ZBTB44 | Gene ID | 29068 |
Gene name | zinc finger and BTB domain containing 44 | |
Gene Alias | BTBD15 | |
Cytomap | 11q24.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | H7BY22 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29068 | ZBTB44 | LZE4T | Human | Esophagus | ESCC | 1.28e-02 | -2.18e-02 | 0.0811 |
29068 | ZBTB44 | LZE7T | Human | Esophagus | ESCC | 3.49e-06 | 3.43e-02 | 0.0667 |
29068 | ZBTB44 | LZE20T | Human | Esophagus | ESCC | 2.98e-04 | 5.47e-02 | 0.0662 |
29068 | ZBTB44 | LZE22T | Human | Esophagus | ESCC | 7.17e-04 | 5.01e-02 | 0.068 |
29068 | ZBTB44 | LZE24T | Human | Esophagus | ESCC | 1.49e-19 | 4.91e-01 | 0.0596 |
29068 | ZBTB44 | LZE21T | Human | Esophagus | ESCC | 8.18e-06 | 6.39e-02 | 0.0655 |
29068 | ZBTB44 | LZE6T | Human | Esophagus | ESCC | 1.20e-05 | 1.31e-02 | 0.0845 |
29068 | ZBTB44 | P2T-E | Human | Esophagus | ESCC | 4.63e-11 | 1.51e-01 | 0.1177 |
29068 | ZBTB44 | P4T-E | Human | Esophagus | ESCC | 2.15e-22 | 4.57e-01 | 0.1323 |
29068 | ZBTB44 | P5T-E | Human | Esophagus | ESCC | 3.71e-05 | -2.79e-03 | 0.1327 |
29068 | ZBTB44 | P8T-E | Human | Esophagus | ESCC | 1.10e-23 | 4.73e-01 | 0.0889 |
29068 | ZBTB44 | P9T-E | Human | Esophagus | ESCC | 4.79e-13 | 7.23e-02 | 0.1131 |
29068 | ZBTB44 | P10T-E | Human | Esophagus | ESCC | 6.32e-28 | 5.10e-01 | 0.116 |
29068 | ZBTB44 | P11T-E | Human | Esophagus | ESCC | 1.74e-10 | 2.60e-01 | 0.1426 |
29068 | ZBTB44 | P12T-E | Human | Esophagus | ESCC | 3.38e-19 | 3.28e-01 | 0.1122 |
29068 | ZBTB44 | P15T-E | Human | Esophagus | ESCC | 4.21e-22 | 5.49e-02 | 0.1149 |
29068 | ZBTB44 | P16T-E | Human | Esophagus | ESCC | 3.01e-25 | 3.20e-01 | 0.1153 |
29068 | ZBTB44 | P17T-E | Human | Esophagus | ESCC | 9.34e-04 | 7.98e-02 | 0.1278 |
29068 | ZBTB44 | P20T-E | Human | Esophagus | ESCC | 1.96e-19 | 1.37e-01 | 0.1124 |
29068 | ZBTB44 | P21T-E | Human | Esophagus | ESCC | 5.76e-16 | 2.89e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB44 | SNV | Missense_Mutation | c.1013N>A | p.Ser338Tyr | p.S338Y | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZBTB44 | SNV | Missense_Mutation | c.583N>T | p.Pro195Ser | p.P195S | protein_coding | tolerated(0.09) | possibly_damaging(0.908) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZBTB44 | SNV | Missense_Mutation | c.238A>G | p.Thr80Ala | p.T80A | protein_coding | tolerated(0.62) | benign(0.005) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZBTB44 | SNV | Missense_Mutation | novel | c.1150N>G | p.Thr384Ala | p.T384A | protein_coding | tolerated(1) | benign(0.024) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZBTB44 | SNV | Missense_Mutation | novel | c.355N>G | p.Thr119Ala | p.T119A | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZBTB44 | SNV | Missense_Mutation | novel | c.74G>A | p.Arg25Gln | p.R25Q | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB44 | SNV | Missense_Mutation | c.629N>A | p.Ser210Tyr | p.S210Y | protein_coding | tolerated(0.06) | possibly_damaging(0.473) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZBTB44 | SNV | Missense_Mutation | rs777637095 | c.1480N>A | p.Ala494Thr | p.A494T | protein_coding | tolerated(0.25) | probably_damaging(0.998) | TCGA-AX-A05S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin & Paclitaxel | PD | |
ZBTB44 | SNV | Missense_Mutation | c.353N>T | p.Ser118Ile | p.S118I | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZBTB44 | SNV | Missense_Mutation | novel | c.551N>A | p.Arg184His | p.R184H | protein_coding | tolerated(0.18) | probably_damaging(0.994) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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