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Gene: ZBTB25 |
Gene summary for ZBTB25 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZBTB25 | Gene ID | 7597 |
Gene name | zinc finger and BTB domain containing 25 | |
Gene Alias | C14orf51 | |
Cytomap | 14q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P24278 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7597 | ZBTB25 | LZE4T | Human | Esophagus | ESCC | 3.90e-09 | 2.41e-01 | 0.0811 |
7597 | ZBTB25 | LZE24T | Human | Esophagus | ESCC | 2.62e-08 | 2.74e-01 | 0.0596 |
7597 | ZBTB25 | LZE21T | Human | Esophagus | ESCC | 2.58e-03 | 2.24e-01 | 0.0655 |
7597 | ZBTB25 | P2T-E | Human | Esophagus | ESCC | 2.58e-11 | 2.41e-01 | 0.1177 |
7597 | ZBTB25 | P4T-E | Human | Esophagus | ESCC | 8.49e-12 | 1.86e-01 | 0.1323 |
7597 | ZBTB25 | P5T-E | Human | Esophagus | ESCC | 3.50e-05 | 1.51e-01 | 0.1327 |
7597 | ZBTB25 | P8T-E | Human | Esophagus | ESCC | 3.78e-09 | 1.49e-01 | 0.0889 |
7597 | ZBTB25 | P9T-E | Human | Esophagus | ESCC | 1.09e-04 | 9.18e-02 | 0.1131 |
7597 | ZBTB25 | P10T-E | Human | Esophagus | ESCC | 5.71e-26 | 4.99e-01 | 0.116 |
7597 | ZBTB25 | P11T-E | Human | Esophagus | ESCC | 1.01e-04 | 3.06e-01 | 0.1426 |
7597 | ZBTB25 | P12T-E | Human | Esophagus | ESCC | 5.71e-19 | 3.79e-01 | 0.1122 |
7597 | ZBTB25 | P15T-E | Human | Esophagus | ESCC | 3.10e-28 | 6.68e-01 | 0.1149 |
7597 | ZBTB25 | P16T-E | Human | Esophagus | ESCC | 2.71e-14 | 2.32e-01 | 0.1153 |
7597 | ZBTB25 | P17T-E | Human | Esophagus | ESCC | 2.76e-02 | 2.39e-01 | 0.1278 |
7597 | ZBTB25 | P20T-E | Human | Esophagus | ESCC | 2.37e-07 | 1.66e-01 | 0.1124 |
7597 | ZBTB25 | P21T-E | Human | Esophagus | ESCC | 2.13e-14 | 2.35e-01 | 0.1617 |
7597 | ZBTB25 | P22T-E | Human | Esophagus | ESCC | 5.67e-13 | 2.65e-01 | 0.1236 |
7597 | ZBTB25 | P23T-E | Human | Esophagus | ESCC | 5.36e-04 | 1.41e-01 | 0.108 |
7597 | ZBTB25 | P24T-E | Human | Esophagus | ESCC | 1.41e-04 | 7.58e-02 | 0.1287 |
7597 | ZBTB25 | P26T-E | Human | Esophagus | ESCC | 7.41e-27 | 4.12e-01 | 0.1276 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB25 | SNV | Missense_Mutation | c.186N>C | p.Lys62Asn | p.K62N | P24278 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB25 | SNV | Missense_Mutation | c.719N>A | p.Cys240Tyr | p.C240Y | P24278 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZBTB25 | SNV | Missense_Mutation | novel | c.935C>T | p.Thr312Ile | p.T312I | P24278 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ZBTB25 | SNV | Missense_Mutation | novel | c.621A>T | p.Arg207Ser | p.R207S | P24278 | protein_coding | deleterious(0.05) | benign(0.118) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB25 | SNV | Missense_Mutation | c.304N>A | p.Leu102Ile | p.L102I | P24278 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZBTB25 | SNV | Missense_Mutation | novel | c.464N>A | p.Ser155Asn | p.S155N | P24278 | protein_coding | tolerated(0.5) | benign(0) | TCGA-DF-A2KZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB25 | SNV | Missense_Mutation | novel | c.1244N>G | p.Asp415Gly | p.D415G | P24278 | protein_coding | tolerated(0.29) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ZBTB25 | SNV | Missense_Mutation | rs770190006 | c.1079N>A | p.Arg360Gln | p.R360Q | P24278 | protein_coding | tolerated(0.48) | benign(0.417) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ZBTB25 | SNV | Missense_Mutation | novel | c.1083G>T | p.Lys361Asn | p.K361N | P24278 | protein_coding | deleterious(0) | probably_damaging(0.911) | TCGA-FI-A2F9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB25 | SNV | Missense_Mutation | novel | c.1223N>T | p.Arg408Leu | p.R408L | P24278 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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