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Gene: ZBTB11 |
Gene summary for ZBTB11 |
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Gene information | Species | Human | Gene symbol | ZBTB11 | Gene ID | 27107 |
Gene name | zinc finger and BTB domain containing 11 | |
Gene Alias | MRT69 | |
Cytomap | 3q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O95625 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27107 | ZBTB11 | LZE2T | Human | Esophagus | ESCC | 3.24e-03 | 3.03e-01 | 0.082 |
27107 | ZBTB11 | LZE4T | Human | Esophagus | ESCC | 3.12e-12 | 3.11e-01 | 0.0811 |
27107 | ZBTB11 | LZE7T | Human | Esophagus | ESCC | 2.01e-02 | 6.83e-02 | 0.0667 |
27107 | ZBTB11 | LZE8T | Human | Esophagus | ESCC | 1.89e-06 | 3.75e-02 | 0.067 |
27107 | ZBTB11 | LZE20T | Human | Esophagus | ESCC | 5.58e-06 | 7.70e-02 | 0.0662 |
27107 | ZBTB11 | LZE22T | Human | Esophagus | ESCC | 4.94e-03 | 2.00e-01 | 0.068 |
27107 | ZBTB11 | LZE24T | Human | Esophagus | ESCC | 3.21e-11 | 2.22e-01 | 0.0596 |
27107 | ZBTB11 | P1T-E | Human | Esophagus | ESCC | 1.67e-03 | 2.36e-01 | 0.0875 |
27107 | ZBTB11 | P2T-E | Human | Esophagus | ESCC | 6.57e-19 | 3.97e-01 | 0.1177 |
27107 | ZBTB11 | P4T-E | Human | Esophagus | ESCC | 4.58e-14 | 2.58e-01 | 0.1323 |
27107 | ZBTB11 | P5T-E | Human | Esophagus | ESCC | 5.99e-18 | 4.11e-01 | 0.1327 |
27107 | ZBTB11 | P8T-E | Human | Esophagus | ESCC | 1.95e-18 | 3.15e-01 | 0.0889 |
27107 | ZBTB11 | P9T-E | Human | Esophagus | ESCC | 2.82e-15 | 2.22e-01 | 0.1131 |
27107 | ZBTB11 | P10T-E | Human | Esophagus | ESCC | 5.49e-21 | 3.27e-01 | 0.116 |
27107 | ZBTB11 | P11T-E | Human | Esophagus | ESCC | 2.71e-02 | 2.26e-01 | 0.1426 |
27107 | ZBTB11 | P12T-E | Human | Esophagus | ESCC | 7.67e-15 | 1.16e-01 | 0.1122 |
27107 | ZBTB11 | P15T-E | Human | Esophagus | ESCC | 1.23e-12 | 2.99e-01 | 0.1149 |
27107 | ZBTB11 | P16T-E | Human | Esophagus | ESCC | 1.84e-17 | 3.13e-01 | 0.1153 |
27107 | ZBTB11 | P17T-E | Human | Esophagus | ESCC | 8.41e-09 | 2.24e-01 | 0.1278 |
27107 | ZBTB11 | P19T-E | Human | Esophagus | ESCC | 1.91e-06 | 1.82e-01 | 0.1662 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB11 | SNV | Missense_Mutation | c.2016N>T | p.Lys672Asn | p.K672N | O95625 | protein_coding | tolerated(0.51) | benign(0.113) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB11 | SNV | Missense_Mutation | c.2854N>A | p.Leu952Ile | p.L952I | O95625 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZBTB11 | SNV | Missense_Mutation | c.1454N>T | p.Glu485Val | p.E485V | O95625 | protein_coding | deleterious(0) | benign(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB11 | SNV | Missense_Mutation | novel | c.2971N>A | p.Glu991Lys | p.E991K | O95625 | protein_coding | deleterious_low_confidence(0.01) | benign(0.257) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZBTB11 | SNV | Missense_Mutation | novel | c.1079N>G | p.Asp360Gly | p.D360G | O95625 | protein_coding | tolerated_low_confidence(0.32) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZBTB11 | SNV | Missense_Mutation | c.3092N>C | p.Lys1031Thr | p.K1031T | O95625 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.997) | TCGA-DM-A1D0-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB11 | SNV | Missense_Mutation | novel | c.2265N>T | p.Lys755Asn | p.K755N | O95625 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZBTB11 | SNV | Missense_Mutation | c.2164N>A | p.Leu722Ile | p.L722I | O95625 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZBTB11 | SNV | Missense_Mutation | novel | c.1994N>A | p.Ser665Tyr | p.S665Y | O95625 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZBTB11 | deletion | Frame_Shift_Del | c.2920delG | p.Glu974AsnfsTer14 | p.E974Nfs*14 | O95625 | protein_coding | TCGA-G4-6311-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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