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Gene: WISP1 |
Gene summary for WISP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | WISP1 | Gene ID | 8840 |
Gene name | cellular communication network factor 4 | |
Gene Alias | WISP1 | |
Cytomap | 8q24.22 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | O95388 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8840 | WISP1 | C38 | Human | Oral cavity | OSCC | 3.77e-20 | 1.23e+00 | 0.172 |
8840 | WISP1 | C46 | Human | Oral cavity | OSCC | 1.19e-04 | 1.49e-01 | 0.1673 |
8840 | WISP1 | LN38 | Human | Oral cavity | OSCC | 4.47e-05 | 6.74e-01 | 0.168 |
8840 | WISP1 | LN46 | Human | Oral cavity | OSCC | 9.20e-04 | 2.05e-01 | 0.1666 |
8840 | WISP1 | ATC12 | Human | Thyroid | ATC | 4.82e-02 | 1.00e-01 | 0.34 |
8840 | WISP1 | ATC13 | Human | Thyroid | ATC | 4.82e-02 | 7.86e-02 | 0.34 |
8840 | WISP1 | ATC2 | Human | Thyroid | ATC | 1.60e-07 | 5.69e-01 | 0.34 |
8840 | WISP1 | ATC4 | Human | Thyroid | ATC | 6.21e-03 | 1.20e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WISP1 | SNV | Missense_Mutation | c.881N>A | p.Arg294His | p.R294H | O95388 | protein_coding | deleterious(0.04) | benign(0.058) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WISP1 | deletion | Frame_Shift_Del | c.483delN | p.Pro163ArgfsTer11 | p.P163Rfs*11 | O95388 | protein_coding | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
WISP1 | SNV | Missense_Mutation | novel | c.1054A>T | p.Ile352Phe | p.I352F | O95388 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
WISP1 | SNV | Missense_Mutation | c.917A>T | p.Asp306Val | p.D306V | O95388 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WISP1 | SNV | Missense_Mutation | rs758360129 | c.769C>T | p.Arg257Trp | p.R257W | O95388 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WISP1 | SNV | Missense_Mutation | rs201917230 | c.514C>T | p.Arg172Cys | p.R172C | O95388 | protein_coding | deleterious(0.04) | possibly_damaging(0.908) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WISP1 | SNV | Missense_Mutation | novel | c.742N>A | p.Glu248Lys | p.E248K | O95388 | protein_coding | tolerated(0.33) | benign(0.253) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
WISP1 | SNV | Missense_Mutation | rs760043627 | c.562N>A | p.Asp188Asn | p.D188N | O95388 | protein_coding | tolerated(0.21) | possibly_damaging(0.458) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WISP1 | SNV | Missense_Mutation | c.154N>T | p.Pro52Ser | p.P52S | O95388 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WISP1 | SNV | Missense_Mutation | rs766728121 | c.955N>A | p.Asp319Asn | p.D319N | O95388 | protein_coding | tolerated(0.4) | benign(0.034) | TCGA-AP-A0LF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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