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Gene: WDR36 |
Gene summary for WDR36 |
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Gene information | Species | Human | Gene symbol | WDR36 | Gene ID | 134430 |
Gene name | WD repeat domain 36 | |
Gene Alias | GLC1G | |
Cytomap | 5q22.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q8NI36 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
134430 | WDR36 | LZE4T | Human | Esophagus | ESCC | 1.28e-07 | 5.17e-02 | 0.0811 |
134430 | WDR36 | LZE7T | Human | Esophagus | ESCC | 6.68e-06 | 1.50e-01 | 0.0667 |
134430 | WDR36 | LZE8T | Human | Esophagus | ESCC | 1.76e-07 | 3.85e-02 | 0.067 |
134430 | WDR36 | LZE20T | Human | Esophagus | ESCC | 9.77e-04 | 6.79e-02 | 0.0662 |
134430 | WDR36 | LZE24T | Human | Esophagus | ESCC | 4.77e-15 | 1.91e-01 | 0.0596 |
134430 | WDR36 | LZE6T | Human | Esophagus | ESCC | 4.76e-02 | 5.31e-02 | 0.0845 |
134430 | WDR36 | P1T-E | Human | Esophagus | ESCC | 3.70e-02 | 1.27e-01 | 0.0875 |
134430 | WDR36 | P2T-E | Human | Esophagus | ESCC | 5.86e-20 | 2.67e-01 | 0.1177 |
134430 | WDR36 | P4T-E | Human | Esophagus | ESCC | 1.44e-06 | 1.34e-01 | 0.1323 |
134430 | WDR36 | P5T-E | Human | Esophagus | ESCC | 2.41e-15 | 8.62e-02 | 0.1327 |
134430 | WDR36 | P8T-E | Human | Esophagus | ESCC | 3.16e-10 | 7.70e-02 | 0.0889 |
134430 | WDR36 | P9T-E | Human | Esophagus | ESCC | 5.58e-09 | 7.68e-02 | 0.1131 |
134430 | WDR36 | P10T-E | Human | Esophagus | ESCC | 3.48e-14 | 1.44e-01 | 0.116 |
134430 | WDR36 | P11T-E | Human | Esophagus | ESCC | 2.62e-13 | 2.25e-01 | 0.1426 |
134430 | WDR36 | P12T-E | Human | Esophagus | ESCC | 3.88e-15 | 2.90e-01 | 0.1122 |
134430 | WDR36 | P15T-E | Human | Esophagus | ESCC | 1.29e-23 | 4.53e-01 | 0.1149 |
134430 | WDR36 | P16T-E | Human | Esophagus | ESCC | 1.75e-16 | 5.27e-02 | 0.1153 |
134430 | WDR36 | P17T-E | Human | Esophagus | ESCC | 8.24e-04 | 2.64e-01 | 0.1278 |
134430 | WDR36 | P19T-E | Human | Esophagus | ESCC | 1.79e-05 | 3.40e-01 | 0.1662 |
134430 | WDR36 | P20T-E | Human | Esophagus | ESCC | 4.06e-28 | 5.63e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:002261329 | Skin | cSCC | ribonucleoprotein complex biogenesis | 302/4864 | 463/18723 | 5.13e-72 | 3.22e-68 | 302 |
GO:004225428 | Skin | cSCC | ribosome biogenesis | 206/4864 | 299/18723 | 3.33e-55 | 1.04e-51 | 206 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR36 | SNV | Missense_Mutation | c.2522A>G | p.Asp841Gly | p.D841G | Q8NI36 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WDR36 | SNV | Missense_Mutation | c.2464N>C | p.Ala822Pro | p.A822P | Q8NI36 | protein_coding | tolerated(0.26) | possibly_damaging(0.901) | TCGA-AA-3982-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
WDR36 | SNV | Missense_Mutation | c.83N>T | p.Arg28Met | p.R28M | Q8NI36 | protein_coding | deleterious_low_confidence(0) | benign(0.065) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
WDR36 | SNV | Missense_Mutation | c.1943N>A | p.Thr648Asn | p.T648N | Q8NI36 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
WDR36 | SNV | Missense_Mutation | rs748219538 | c.892N>T | p.Arg298Cys | p.R298C | Q8NI36 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WDR36 | SNV | Missense_Mutation | rs747852074 | c.11N>G | p.Thr4Ser | p.T4S | Q8NI36 | protein_coding | deleterious_low_confidence(0) | benign(0.058) | TCGA-CA-5256-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR |
WDR36 | SNV | Missense_Mutation | novel | c.1431N>C | p.Lys477Asn | p.K477N | Q8NI36 | protein_coding | deleterious(0.01) | benign(0.19) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
WDR36 | SNV | Missense_Mutation | c.1969A>T | p.Ile657Leu | p.I657L | Q8NI36 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
WDR36 | SNV | Missense_Mutation | novel | c.431N>C | p.Val144Ala | p.V144A | Q8NI36 | protein_coding | tolerated(0.46) | possibly_damaging(0.516) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR36 | SNV | Missense_Mutation | rs756283539 | c.487N>A | p.Ala163Thr | p.A163T | Q8NI36 | protein_coding | tolerated(0.22) | benign(0.409) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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