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Gene: WASHC5 |
Gene summary for WASHC5 |
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Gene information | Species | Human | Gene symbol | WASHC5 | Gene ID | 9897 |
Gene name | WASH complex subunit 5 | |
Gene Alias | KIAA0196 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | E7EQI7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9897 | WASHC5 | HCC1 | Human | Liver | HCC | 7.45e-06 | 2.75e+00 | 0.5336 |
9897 | WASHC5 | HCC2 | Human | Liver | HCC | 3.03e-22 | 3.84e+00 | 0.5341 |
9897 | WASHC5 | S014 | Human | Liver | HCC | 1.04e-33 | 8.62e-01 | 0.2254 |
9897 | WASHC5 | S015 | Human | Liver | HCC | 3.39e-30 | 9.39e-01 | 0.2375 |
9897 | WASHC5 | S016 | Human | Liver | HCC | 6.57e-31 | 8.17e-01 | 0.2243 |
9897 | WASHC5 | S027 | Human | Liver | HCC | 4.42e-21 | 1.19e+00 | 0.2446 |
9897 | WASHC5 | S028 | Human | Liver | HCC | 7.73e-41 | 1.37e+00 | 0.2503 |
9897 | WASHC5 | S029 | Human | Liver | HCC | 7.12e-45 | 1.64e+00 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:001605021 | Liver | HCC | vesicle organization | 194/7958 | 300/18723 | 5.58e-15 | 3.97e-13 | 194 |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
GO:005125822 | Liver | HCC | protein polymerization | 182/7958 | 297/18723 | 4.17e-11 | 1.58e-09 | 182 |
GO:003133412 | Liver | HCC | positive regulation of protein-containing complex assembly | 150/7958 | 237/18723 | 7.35e-11 | 2.63e-09 | 150 |
GO:000703311 | Liver | HCC | vacuole organization | 119/7958 | 180/18723 | 1.22e-10 | 4.25e-09 | 119 |
GO:190290322 | Liver | HCC | regulation of supramolecular fiber organization | 224/7958 | 383/18723 | 1.54e-10 | 5.33e-09 | 224 |
GO:000701522 | Liver | HCC | actin filament organization | 252/7958 | 442/18723 | 3.83e-10 | 1.25e-08 | 252 |
GO:190290522 | Liver | HCC | positive regulation of supramolecular fiber organization | 131/7958 | 209/18723 | 2.85e-09 | 7.69e-08 | 131 |
GO:000703211 | Liver | HCC | endosome organization | 61/7958 | 82/18723 | 4.36e-09 | 1.15e-07 | 61 |
GO:005149522 | Liver | HCC | positive regulation of cytoskeleton organization | 138/7958 | 226/18723 | 1.26e-08 | 3.12e-07 | 138 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:000705111 | Liver | HCC | spindle organization | 116/7958 | 184/18723 | 1.40e-08 | 3.40e-07 | 116 |
GO:003227122 | Liver | HCC | regulation of protein polymerization | 141/7958 | 233/18723 | 2.00e-08 | 4.72e-07 | 141 |
GO:003297022 | Liver | HCC | regulation of actin filament-based process | 222/7958 | 397/18723 | 3.81e-08 | 8.30e-07 | 222 |
GO:003227322 | Liver | HCC | positive regulation of protein polymerization | 90/7958 | 138/18723 | 5.73e-08 | 1.21e-06 | 90 |
GO:003295622 | Liver | HCC | regulation of actin cytoskeleton organization | 202/7958 | 358/18723 | 6.18e-08 | 1.29e-06 | 202 |
GO:000815422 | Liver | HCC | actin polymerization or depolymerization | 130/7958 | 218/18723 | 2.31e-07 | 4.14e-06 | 130 |
GO:003004122 | Liver | HCC | actin filament polymerization | 116/7958 | 191/18723 | 2.66e-07 | 4.68e-06 | 116 |
GO:011005322 | Liver | HCC | regulation of actin filament organization | 158/7958 | 278/18723 | 9.01e-07 | 1.37e-05 | 158 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WASHC5 | SNV | Missense_Mutation | rs868624669 | c.2237N>T | p.Ala746Val | p.A746V | Q12768 | protein_coding | tolerated(0.25) | probably_damaging(0.989) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WASHC5 | SNV | Missense_Mutation | novel | c.1075N>T | p.Ile359Phe | p.I359F | Q12768 | protein_coding | tolerated(0.13) | probably_damaging(0.979) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
WASHC5 | SNV | Missense_Mutation | c.3034N>C | p.Glu1012Gln | p.E1012Q | Q12768 | protein_coding | tolerated(0.05) | benign(0.291) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
WASHC5 | SNV | Missense_Mutation | novel | c.2510C>A | p.Thr837Lys | p.T837K | Q12768 | protein_coding | deleterious(0) | benign(0.175) | TCGA-FU-A3TQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
WASHC5 | SNV | Missense_Mutation | c.1354G>C | p.Glu452Gln | p.E452Q | Q12768 | protein_coding | deleterious(0) | possibly_damaging(0.596) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
WASHC5 | SNV | Missense_Mutation | c.1903T>G | p.Phe635Val | p.F635V | Q12768 | protein_coding | deleterious(0) | benign(0.011) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
WASHC5 | SNV | Missense_Mutation | rs754246927 | c.1172N>A | p.Arg391His | p.R391H | Q12768 | protein_coding | deleterious(0.05) | probably_damaging(0.994) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WASHC5 | SNV | Missense_Mutation | c.2482A>T | p.Ile828Phe | p.I828F | Q12768 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-AZ-6608-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
WASHC5 | SNV | Missense_Mutation | novel | c.1517N>T | p.Glu506Val | p.E506V | Q12768 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
WASHC5 | SNV | Missense_Mutation | novel | c.1318N>A | p.Glu440Lys | p.E440K | Q12768 | protein_coding | tolerated(0.44) | probably_damaging(0.982) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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