![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: UTP14A |
Gene summary for UTP14A |
![]() |
Gene information | Species | Human | Gene symbol | UTP14A | Gene ID | 10813 |
Gene name | UTP14A small subunit processome component | |
Gene Alias | NYCO16 | |
Cytomap | Xq26.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BVJ6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10813 | UTP14A | LZE2T | Human | Esophagus | ESCC | 3.49e-02 | 4.81e-01 | 0.082 |
10813 | UTP14A | LZE4T | Human | Esophagus | ESCC | 2.73e-11 | 2.27e-01 | 0.0811 |
10813 | UTP14A | LZE7T | Human | Esophagus | ESCC | 1.02e-03 | 2.70e-01 | 0.0667 |
10813 | UTP14A | LZE20T | Human | Esophagus | ESCC | 5.74e-04 | 1.16e-01 | 0.0662 |
10813 | UTP14A | LZE24T | Human | Esophagus | ESCC | 1.21e-16 | 5.07e-01 | 0.0596 |
10813 | UTP14A | LZE6T | Human | Esophagus | ESCC | 3.78e-03 | 1.23e-01 | 0.0845 |
10813 | UTP14A | P2T-E | Human | Esophagus | ESCC | 3.62e-23 | 3.97e-01 | 0.1177 |
10813 | UTP14A | P4T-E | Human | Esophagus | ESCC | 2.38e-13 | 2.71e-01 | 0.1323 |
10813 | UTP14A | P5T-E | Human | Esophagus | ESCC | 1.79e-17 | 3.17e-01 | 0.1327 |
10813 | UTP14A | P8T-E | Human | Esophagus | ESCC | 1.09e-13 | 1.92e-01 | 0.0889 |
10813 | UTP14A | P9T-E | Human | Esophagus | ESCC | 8.17e-16 | 2.87e-01 | 0.1131 |
10813 | UTP14A | P10T-E | Human | Esophagus | ESCC | 5.47e-24 | 3.88e-01 | 0.116 |
10813 | UTP14A | P11T-E | Human | Esophagus | ESCC | 8.32e-06 | 2.68e-01 | 0.1426 |
10813 | UTP14A | P12T-E | Human | Esophagus | ESCC | 5.10e-11 | 1.61e-01 | 0.1122 |
10813 | UTP14A | P15T-E | Human | Esophagus | ESCC | 7.88e-11 | 2.24e-01 | 0.1149 |
10813 | UTP14A | P16T-E | Human | Esophagus | ESCC | 2.03e-12 | 1.68e-01 | 0.1153 |
10813 | UTP14A | P17T-E | Human | Esophagus | ESCC | 5.82e-06 | 4.02e-01 | 0.1278 |
10813 | UTP14A | P20T-E | Human | Esophagus | ESCC | 2.28e-08 | 3.15e-01 | 0.1124 |
10813 | UTP14A | P21T-E | Human | Esophagus | ESCC | 3.21e-28 | 4.75e-01 | 0.1617 |
10813 | UTP14A | P22T-E | Human | Esophagus | ESCC | 7.29e-25 | 4.36e-01 | 0.1236 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UTP14A | SNV | Missense_Mutation | novel | c.1101N>A | p.Met367Ile | p.M367I | Q9BVJ6 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UTP14A | SNV | Missense_Mutation | c.86G>C | p.Ser29Thr | p.S29T | Q9BVJ6 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UTP14A | SNV | Missense_Mutation | novel | c.1468N>A | p.Glu490Lys | p.E490K | Q9BVJ6 | protein_coding | tolerated(0.08) | possibly_damaging(0.515) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UTP14A | SNV | Missense_Mutation | novel | c.373N>T | p.Ile125Phe | p.I125F | Q9BVJ6 | protein_coding | deleterious(0.03) | possibly_damaging(0.524) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UTP14A | SNV | Missense_Mutation | novel | c.1808N>T | p.Asp603Val | p.D603V | Q9BVJ6 | protein_coding | deleterious(0.01) | possibly_damaging(0.846) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UTP14A | SNV | Missense_Mutation | rs749551821 | c.442N>A | p.Val148Ile | p.V148I | Q9BVJ6 | protein_coding | tolerated(0.17) | benign(0.018) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
UTP14A | SNV | Missense_Mutation | c.1365N>T | p.Glu455Asp | p.E455D | Q9BVJ6 | protein_coding | tolerated(0.09) | benign(0.015) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UTP14A | SNV | Missense_Mutation | c.780G>T | p.Lys260Asn | p.K260N | Q9BVJ6 | protein_coding | deleterious(0.02) | possibly_damaging(0.597) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UTP14A | SNV | Missense_Mutation | c.1957G>A | p.Ala653Thr | p.A653T | Q9BVJ6 | protein_coding | tolerated(0.11) | benign(0.014) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UTP14A | SNV | Missense_Mutation | c.1714G>A | p.Val572Met | p.V572M | Q9BVJ6 | protein_coding | tolerated(0.22) | benign(0.075) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |