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Gene: UST |
Gene summary for UST |
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Gene information | Species | Human | Gene symbol | UST | Gene ID | 10090 |
Gene name | uronyl 2-sulfotransferase | |
Gene Alias | 2OST | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9Y2C2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10090 | UST | CCI_1 | Human | Cervix | CC | 4.60e-04 | 5.02e-01 | 0.528 |
10090 | UST | CCI_2 | Human | Cervix | CC | 1.25e-18 | 1.50e+00 | 0.5249 |
10090 | UST | CCI_3 | Human | Cervix | CC | 8.49e-04 | 3.10e-01 | 0.516 |
10090 | UST | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.11e-07 | 2.72e-01 | 0.0674 |
10090 | UST | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.49e-35 | 6.73e-01 | 0.294 |
10090 | UST | A015-C-005 | Human | Colorectum | FAP | 6.68e-04 | 3.43e-01 | -0.0336 |
10090 | UST | HCC1 | Human | Liver | HCC | 3.29e-07 | 5.30e-01 | 0.5336 |
10090 | UST | HCC2 | Human | Liver | HCC | 2.08e-08 | 6.33e-01 | 0.5341 |
10090 | UST | HCC5 | Human | Liver | HCC | 5.72e-12 | 6.62e-01 | 0.4932 |
10090 | UST | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 3.74e-02 | 8.36e-01 | -0.1408 |
10090 | UST | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.62e-19 | 7.94e-01 | -0.2116 |
10090 | UST | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 3.11e-08 | 8.18e-01 | -0.1941 |
10090 | UST | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.91e-16 | 9.61e-01 | -0.2107 |
10090 | UST | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 5.15e-12 | 7.42e-01 | -0.2119 |
10090 | UST | RNA-P5T2-P5T2-1 | Human | Lung | MIAC | 3.63e-03 | 1.31e+00 | -0.0135 |
10090 | UST | RNA-P5T2-P5T2-3 | Human | Lung | MIAC | 1.56e-03 | 1.41e+00 | 0.0176 |
10090 | UST | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.31e-03 | 8.94e-01 | -0.0238 |
10090 | UST | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 4.62e-06 | 9.97e-01 | -0.0296 |
10090 | UST | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 3.17e-07 | 9.49e-01 | -0.0263 |
10090 | UST | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 7.06e-24 | 7.47e-01 | -0.0166 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:00300108 | Cervix | CC | establishment of cell polarity | 42/2311 | 143/18723 | 4.30e-08 | 2.62e-06 | 42 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00507705 | Cervix | CC | regulation of axonogenesis | 34/2311 | 154/18723 | 4.87e-04 | 4.76e-03 | 34 |
GO:0007163 | Colorectum | AD | establishment or maintenance of cell polarity | 77/3918 | 218/18723 | 5.72e-07 | 2.08e-05 | 77 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0030010 | Colorectum | AD | establishment of cell polarity | 50/3918 | 143/18723 | 6.90e-05 | 1.11e-03 | 50 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0050770 | Colorectum | AD | regulation of axonogenesis | 49/3918 | 154/18723 | 9.88e-04 | 9.28e-03 | 49 |
GO:00071632 | Colorectum | MSS | establishment or maintenance of cell polarity | 72/3467 | 218/18723 | 1.90e-07 | 8.30e-06 | 72 |
GO:00300102 | Colorectum | MSS | establishment of cell polarity | 47/3467 | 143/18723 | 2.74e-05 | 5.58e-04 | 47 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00507701 | Colorectum | MSS | regulation of axonogenesis | 43/3467 | 154/18723 | 2.69e-03 | 2.12e-02 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UST | SNV | Missense_Mutation | novel | c.1025N>T | p.Arg342Ile | p.R342I | Q9Y2C2 | protein_coding | tolerated(0.08) | benign(0.37) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
UST | SNV | Missense_Mutation | c.850N>A | p.Leu284Ile | p.L284I | Q9Y2C2 | protein_coding | tolerated(0.05) | possibly_damaging(0.855) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
UST | SNV | Missense_Mutation | rs755609661 | c.820N>A | p.Val274Met | p.V274M | Q9Y2C2 | protein_coding | deleterious(0.03) | probably_damaging(0.988) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UST | SNV | Missense_Mutation | rs747844853 | c.242A>G | p.Tyr81Cys | p.Y81C | Q9Y2C2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.867) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
UST | SNV | Missense_Mutation | c.850N>A | p.Leu284Ile | p.L284I | Q9Y2C2 | protein_coding | tolerated(0.05) | possibly_damaging(0.855) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UST | SNV | Missense_Mutation | novel | c.998N>T | p.Ala333Val | p.A333V | Q9Y2C2 | protein_coding | tolerated(0.32) | benign(0.114) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
UST | deletion | Frame_Shift_Del | rs766240903 | c.1111delN | p.Leu373Ter | p.L373* | Q9Y2C2 | protein_coding | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
UST | deletion | Frame_Shift_Del | rs766240903 | c.1111delN | p.Leu373Ter | p.L373* | Q9Y2C2 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
UST | insertion | Frame_Shift_Ins | rs760552029 | c.1110_1111insC | p.Leu373ProfsTer20 | p.L373Pfs*20 | Q9Y2C2 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
UST | deletion | Frame_Shift_Del | c.63delN | p.Gly23AlafsTer88 | p.G23Afs*88 | Q9Y2C2 | protein_coding | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10090 | UST | NA | nortriptyline | NORTRIPTYLINE | 20360315,25916525 |
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