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Gene: USP12 |
Gene summary for USP12 |
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Gene information | Species | Human | Gene symbol | USP12 | Gene ID | 219333 |
Gene name | ubiquitin specific peptidase 12 | |
Gene Alias | UBH1 | |
Cytomap | 13q12.13 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | O75317 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219333 | USP12 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.28e-14 | -5.44e-01 | 0.0155 |
219333 | USP12 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.28e-04 | -3.77e-01 | -0.1808 |
219333 | USP12 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.48e-02 | -4.27e-01 | -0.1207 |
219333 | USP12 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.38e-07 | -4.01e-01 | -0.1464 |
219333 | USP12 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.47e-07 | -3.92e-01 | -0.1001 |
219333 | USP12 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.85e-02 | -4.84e-01 | -0.0842 |
219333 | USP12 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.73e-12 | -5.33e-01 | 0.096 |
219333 | USP12 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.33e-04 | -4.68e-01 | 0.0338 |
219333 | USP12 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.12e-12 | -4.82e-01 | 0.0674 |
219333 | USP12 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.72e-08 | -4.06e-01 | 0.294 |
219333 | USP12 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.41e-18 | -5.68e-01 | 0.3005 |
219333 | USP12 | A015-C-203 | Human | Colorectum | FAP | 1.64e-21 | -3.57e-01 | -0.1294 |
219333 | USP12 | A015-C-204 | Human | Colorectum | FAP | 3.52e-05 | -2.58e-01 | -0.0228 |
219333 | USP12 | A014-C-040 | Human | Colorectum | FAP | 6.67e-03 | -2.41e-01 | -0.1184 |
219333 | USP12 | A002-C-201 | Human | Colorectum | FAP | 6.99e-13 | -3.26e-01 | 0.0324 |
219333 | USP12 | A002-C-203 | Human | Colorectum | FAP | 3.55e-02 | -2.22e-01 | 0.2786 |
219333 | USP12 | A001-C-119 | Human | Colorectum | FAP | 7.13e-05 | -3.50e-01 | -0.1557 |
219333 | USP12 | A001-C-108 | Human | Colorectum | FAP | 1.77e-09 | -2.54e-01 | -0.0272 |
219333 | USP12 | A002-C-205 | Human | Colorectum | FAP | 6.42e-18 | -3.03e-01 | -0.1236 |
219333 | USP12 | A015-C-005 | Human | Colorectum | FAP | 2.36e-02 | -1.90e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:00060069 | Esophagus | ESCC | glucose metabolic process | 119/8552 | 196/18723 | 1.51e-05 | 1.36e-04 | 119 |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:00620129 | Esophagus | ESCC | regulation of small molecule metabolic process | 184/8552 | 334/18723 | 3.11e-04 | 1.85e-03 | 184 |
GO:00109065 | Esophagus | ESCC | regulation of glucose metabolic process | 71/8552 | 119/18723 | 1.46e-03 | 6.92e-03 | 71 |
GO:00061096 | Esophagus | ESCC | regulation of carbohydrate metabolic process | 101/8552 | 178/18723 | 1.89e-03 | 8.52e-03 | 101 |
GO:00106755 | Esophagus | ESCC | regulation of cellular carbohydrate metabolic process | 83/8552 | 146/18723 | 4.24e-03 | 1.69e-02 | 83 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:000599621 | Liver | HCC | monosaccharide metabolic process | 167/7958 | 257/18723 | 2.31e-13 | 1.25e-11 | 167 |
GO:001931821 | Liver | HCC | hexose metabolic process | 155/7958 | 237/18723 | 7.63e-13 | 3.90e-11 | 155 |
GO:000600621 | Liver | HCC | glucose metabolic process | 128/7958 | 196/18723 | 8.60e-11 | 3.06e-09 | 128 |
GO:006201222 | Liver | HCC | regulation of small molecule metabolic process | 190/7958 | 334/18723 | 6.77e-08 | 1.40e-06 | 190 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
GO:000610921 | Liver | HCC | regulation of carbohydrate metabolic process | 109/7958 | 178/18723 | 3.36e-07 | 5.78e-06 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP12 | SNV | Missense_Mutation | novel | c.969G>C | p.Lys323Asn | p.K323N | O75317 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
USP12 | deletion | Frame_Shift_Del | novel | c.52_59delNNNNNNNN | p.Ala18PhefsTer16 | p.A18Ffs*16 | O75317 | protein_coding | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD | ||
USP12 | SNV | Missense_Mutation | c.184N>G | p.Pro62Ala | p.P62A | O75317 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-A6-6782-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
USP12 | SNV | Missense_Mutation | c.985T>G | p.Leu329Val | p.L329V | O75317 | protein_coding | tolerated(0.08) | probably_damaging(0.947) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
USP12 | SNV | Missense_Mutation | c.145T>A | p.Tyr49Asn | p.Y49N | O75317 | protein_coding | deleterious(0.02) | probably_damaging(0.986) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
USP12 | SNV | Missense_Mutation | novel | c.160C>A | p.Leu54Ile | p.L54I | O75317 | protein_coding | tolerated(0.15) | benign(0.315) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
USP12 | deletion | Frame_Shift_Del | c.750delN | p.Lys250AsnfsTer4 | p.K250Nfs*4 | O75317 | protein_coding | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
USP12 | SNV | Missense_Mutation | novel | c.946N>T | p.Gly316Cys | p.G316C | O75317 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
USP12 | SNV | Missense_Mutation | c.384C>A | p.Phe128Leu | p.F128L | O75317 | protein_coding | deleterious(0.04) | possibly_damaging(0.539) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
USP12 | SNV | Missense_Mutation | novel | c.494N>T | p.Ser165Ile | p.S165I | O75317 | protein_coding | tolerated(0.07) | benign(0.005) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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