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Gene: UNC5CL |
Gene summary for UNC5CL |
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Gene information | Species | Human | Gene symbol | UNC5CL | Gene ID | 222643 |
Gene name | unc-5 family C-terminal like | |
Gene Alias | MUXA | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | H8YHX0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222643 | UNC5CL | HCC1_Meng | Human | Liver | HCC | 1.08e-10 | -3.53e-02 | 0.0246 |
222643 | UNC5CL | HCC2_Meng | Human | Liver | HCC | 2.66e-21 | 1.43e-01 | 0.0107 |
222643 | UNC5CL | S027 | Human | Liver | HCC | 2.54e-05 | 6.24e-01 | 0.2446 |
222643 | UNC5CL | S028 | Human | Liver | HCC | 1.28e-07 | 5.74e-01 | 0.2503 |
222643 | UNC5CL | S029 | Human | Liver | HCC | 3.43e-06 | 5.27e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
GO:004312312 | Liver | HCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 108/7958 | 186/18723 | 1.28e-05 | 1.43e-04 | 108 |
GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
GO:004312212 | Liver | HCC | regulation of I-kappaB kinase/NF-kappaB signaling | 138/7958 | 249/18723 | 2.47e-05 | 2.58e-04 | 138 |
GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
GO:003287222 | Liver | HCC | regulation of stress-activated MAPK cascade | 102/7958 | 192/18723 | 1.86e-03 | 9.49e-03 | 102 |
GO:000725412 | Liver | HCC | JNK cascade | 89/7958 | 167/18723 | 3.09e-03 | 1.44e-02 | 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UNC5CL | SNV | Missense_Mutation | rs139674158 | c.403N>T | p.Arg135Cys | p.R135C | Q8IV45 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNC5CL | SNV | Missense_Mutation | c.621G>T | p.Arg207Ser | p.R207S | Q8IV45 | protein_coding | tolerated(0.35) | benign(0.036) | TCGA-AF-2693-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UNC5CL | SNV | Missense_Mutation | novel | c.329N>C | p.His110Pro | p.H110P | Q8IV45 | protein_coding | deleterious(0.01) | possibly_damaging(0.864) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UNC5CL | SNV | Missense_Mutation | rs759752192 | c.1292N>A | p.Arg431His | p.R431H | Q8IV45 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNC5CL | SNV | Missense_Mutation | c.197N>T | p.Arg66Met | p.R66M | Q8IV45 | protein_coding | tolerated(0.2) | benign(0.171) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UNC5CL | SNV | Missense_Mutation | c.1217N>C | p.Asn406Thr | p.N406T | Q8IV45 | protein_coding | tolerated(0.2) | benign(0.432) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UNC5CL | SNV | Missense_Mutation | rs761887947 | c.1128G>T | p.Glu376Asp | p.E376D | Q8IV45 | protein_coding | deleterious(0.03) | benign(0.36) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNC5CL | SNV | Missense_Mutation | novel | c.682T>G | p.Phe228Val | p.F228V | Q8IV45 | protein_coding | deleterious(0.04) | probably_damaging(0.995) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNC5CL | SNV | Missense_Mutation | rs147879961 | c.1333C>T | p.Arg445Trp | p.R445W | Q8IV45 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UNC5CL | SNV | Missense_Mutation | novel | c.260C>T | p.Thr87Ile | p.T87I | Q8IV45 | protein_coding | tolerated(0.08) | benign(0.276) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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