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Gene: UNC5C |
Gene summary for UNC5C |
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Gene information | Species | Human | Gene symbol | UNC5C | Gene ID | 8633 |
Gene name | unc-5 netrin receptor C | |
Gene Alias | UNC5H3 | |
Cytomap | 4q22.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A8K385 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8633 | UNC5C | male-WTA | Human | Thyroid | PTC | 4.22e-25 | 1.92e-01 | 0.1037 |
8633 | UNC5C | PTC01 | Human | Thyroid | PTC | 2.14e-10 | 9.23e-02 | 0.1899 |
8633 | UNC5C | PTC03 | Human | Thyroid | PTC | 1.63e-05 | 1.14e-01 | 0.1784 |
8633 | UNC5C | PTC04 | Human | Thyroid | PTC | 2.67e-06 | 1.80e-01 | 0.1927 |
8633 | UNC5C | PTC05 | Human | Thyroid | PTC | 5.46e-18 | 6.31e-01 | 0.2065 |
8633 | UNC5C | PTC06 | Human | Thyroid | PTC | 1.64e-17 | 5.30e-01 | 0.2057 |
8633 | UNC5C | PTC07 | Human | Thyroid | PTC | 4.09e-20 | 3.15e-01 | 0.2044 |
8633 | UNC5C | ATC4 | Human | Thyroid | ATC | 1.12e-03 | -7.78e-02 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
GO:004312312 | Liver | HCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 108/7958 | 186/18723 | 1.28e-05 | 1.43e-04 | 108 |
GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
GO:004312212 | Liver | HCC | regulation of I-kappaB kinase/NF-kappaB signaling | 138/7958 | 249/18723 | 2.47e-05 | 2.58e-04 | 138 |
GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
GO:003287222 | Liver | HCC | regulation of stress-activated MAPK cascade | 102/7958 | 192/18723 | 1.86e-03 | 9.49e-03 | 102 |
GO:000725412 | Liver | HCC | JNK cascade | 89/7958 | 167/18723 | 3.09e-03 | 1.44e-02 | 89 |
GO:006156419 | Thyroid | PTC | axon development | 199/5968 | 467/18723 | 5.27e-07 | 8.53e-06 | 199 |
GO:000740918 | Thyroid | PTC | axonogenesis | 178/5968 | 418/18723 | 2.17e-06 | 2.91e-05 | 178 |
GO:006156423 | Thyroid | ATC | axon development | 220/6293 | 467/18723 | 6.85e-10 | 1.80e-08 | 220 |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:00074113 | Thyroid | ATC | axon guidance | 96/6293 | 227/18723 | 3.74e-03 | 1.63e-02 | 96 |
GO:00974853 | Thyroid | ATC | neuron projection guidance | 96/6293 | 228/18723 | 4.36e-03 | 1.81e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UNC5C | SNV | Missense_Mutation | rs767605519 | c.382C>T | p.Arg128Cys | p.R128C | O95185 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UNC5C | SNV | Missense_Mutation | novel | c.166G>A | p.Asp56Asn | p.D56N | O95185 | protein_coding | tolerated(0.1) | probably_damaging(0.971) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UNC5C | SNV | Missense_Mutation | rs774698598 | c.1666G>A | p.Ala556Thr | p.A556T | O95185 | protein_coding | tolerated(0.36) | possibly_damaging(0.805) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD |
UNC5C | SNV | Missense_Mutation | rs777156310 | c.1025C>T | p.Ala342Val | p.A342V | O95185 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UNC5C | SNV | Missense_Mutation | c.61N>A | p.Gln21Lys | p.Q21K | O95185 | protein_coding | tolerated_low_confidence(0.87) | benign(0.007) | TCGA-AA-3556-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UNC5C | SNV | Missense_Mutation | c.523N>A | p.Gly175Arg | p.G175R | O95185 | protein_coding | deleterious(0) | possibly_damaging(0.678) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UNC5C | SNV | Missense_Mutation | c.1090N>T | p.Asp364Tyr | p.D364Y | O95185 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
UNC5C | SNV | Missense_Mutation | c.2029N>T | p.Ala677Ser | p.A677S | O95185 | protein_coding | tolerated(0.58) | benign(0.007) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UNC5C | SNV | Missense_Mutation | c.2030N>T | p.Ala677Val | p.A677V | O95185 | protein_coding | deleterious(0.04) | benign(0.198) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
UNC5C | SNV | Missense_Mutation | c.590N>A | p.Ala197Asp | p.A197D | O95185 | protein_coding | deleterious(0) | benign(0.011) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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