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Gene: UBL7 |
Gene summary for UBL7 |
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Gene information | Species | Human | Gene symbol | UBL7 | Gene ID | 84993 |
Gene name | ubiquitin like 7 | |
Gene Alias | BMSC-UbP | |
Cytomap | 15q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q96S82 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84993 | UBL7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.73e-03 | 2.22e-01 | -0.1808 |
84993 | UBL7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.05e-02 | 3.17e-01 | 0.0216 |
84993 | UBL7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.32e-05 | 2.80e-01 | -0.1207 |
84993 | UBL7 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.44e-09 | 2.75e-01 | -0.1464 |
84993 | UBL7 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.51e-04 | 1.41e-01 | -0.1001 |
84993 | UBL7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.81e-07 | 2.73e-01 | -0.059 |
84993 | UBL7 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.12e-03 | 2.71e-01 | -0.0842 |
84993 | UBL7 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.47e-05 | 2.03e-01 | 0.096 |
84993 | UBL7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.65e-04 | 1.44e-01 | 0.0674 |
84993 | UBL7 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.58e-02 | 2.11e-01 | 0.0588 |
84993 | UBL7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.22e-04 | 1.47e-01 | 0.3859 |
84993 | UBL7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.03e-06 | 2.06e-01 | 0.3005 |
84993 | UBL7 | LZE4T | Human | Esophagus | ESCC | 3.70e-07 | 3.66e-01 | 0.0811 |
84993 | UBL7 | LZE7T | Human | Esophagus | ESCC | 5.97e-14 | 6.75e-01 | 0.0667 |
84993 | UBL7 | LZE8T | Human | Esophagus | ESCC | 8.29e-06 | 2.53e-01 | 0.067 |
84993 | UBL7 | LZE20T | Human | Esophagus | ESCC | 5.15e-03 | 2.38e-01 | 0.0662 |
84993 | UBL7 | LZE22T | Human | Esophagus | ESCC | 1.04e-09 | 4.88e-01 | 0.068 |
84993 | UBL7 | LZE24T | Human | Esophagus | ESCC | 9.80e-18 | 4.21e-01 | 0.0596 |
84993 | UBL7 | LZE6T | Human | Esophagus | ESCC | 7.49e-12 | 6.88e-01 | 0.0845 |
84993 | UBL7 | P1T-E | Human | Esophagus | ESCC | 2.25e-07 | 4.96e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBL7 | SNV | Missense_Mutation | novel | c.416N>A | p.Ser139Tyr | p.S139Y | Q96S82 | protein_coding | deleterious(0.02) | probably_damaging(0.953) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UBL7 | SNV | Missense_Mutation | c.830N>T | p.Ala277Val | p.A277V | Q96S82 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-D1-A17F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBL7 | SNV | Missense_Mutation | c.976N>A | p.Leu326Ile | p.L326I | Q96S82 | protein_coding | tolerated(0.2) | probably_damaging(0.987) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
UBL7 | SNV | Missense_Mutation | novel | c.116N>A | p.Ser39Asn | p.S39N | Q96S82 | protein_coding | tolerated(0.11) | benign(0.182) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBL7 | SNV | Missense_Mutation | rs199841006 | c.508N>A | p.Ala170Thr | p.A170T | Q96S82 | protein_coding | tolerated(0.67) | benign(0.003) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
UBL7 | SNV | Missense_Mutation | novel | c.764N>T | p.Ser255Phe | p.S255F | Q96S82 | protein_coding | deleterious(0.01) | possibly_damaging(0.758) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
UBL7 | SNV | Missense_Mutation | novel | c.493N>G | p.Leu165Val | p.L165V | Q96S82 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-94-A5I4-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
UBL7 | SNV | Missense_Mutation | rs777060082 | c.845N>T | p.Pro282Leu | p.P282L | Q96S82 | protein_coding | deleterious(0.03) | benign(0.005) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBL7 | SNV | Missense_Mutation | rs777060082 | c.845N>T | p.Pro282Leu | p.P282L | Q96S82 | protein_coding | deleterious(0.03) | benign(0.005) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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