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Gene: UBE2W |
Gene summary for UBE2W |
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Gene information | Species | Human | Gene symbol | UBE2W | Gene ID | 55284 |
Gene name | ubiquitin conjugating enzyme E2 W | |
Gene Alias | UBC-16 | |
Cytomap | 8q21.11 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q96B02 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55284 | UBE2W | LZE4T | Human | Esophagus | ESCC | 2.35e-20 | 6.53e-01 | 0.0811 |
55284 | UBE2W | LZE7T | Human | Esophagus | ESCC | 1.60e-07 | 2.77e-01 | 0.0667 |
55284 | UBE2W | LZE8T | Human | Esophagus | ESCC | 6.74e-03 | 1.95e-01 | 0.067 |
55284 | UBE2W | LZE20T | Human | Esophagus | ESCC | 1.73e-06 | 3.18e-01 | 0.0662 |
55284 | UBE2W | LZE22T | Human | Esophagus | ESCC | 2.37e-02 | 2.18e-01 | 0.068 |
55284 | UBE2W | LZE24T | Human | Esophagus | ESCC | 5.50e-18 | 5.18e-01 | 0.0596 |
55284 | UBE2W | LZE6T | Human | Esophagus | ESCC | 9.78e-08 | 2.92e-01 | 0.0845 |
55284 | UBE2W | P1T-E | Human | Esophagus | ESCC | 2.80e-02 | 2.05e-01 | 0.0875 |
55284 | UBE2W | P2T-E | Human | Esophagus | ESCC | 7.38e-12 | 1.38e-01 | 0.1177 |
55284 | UBE2W | P4T-E | Human | Esophagus | ESCC | 3.10e-19 | 3.30e-01 | 0.1323 |
55284 | UBE2W | P5T-E | Human | Esophagus | ESCC | 4.15e-13 | 2.49e-01 | 0.1327 |
55284 | UBE2W | P8T-E | Human | Esophagus | ESCC | 3.65e-13 | 2.17e-01 | 0.0889 |
55284 | UBE2W | P9T-E | Human | Esophagus | ESCC | 2.08e-04 | 1.81e-01 | 0.1131 |
55284 | UBE2W | P10T-E | Human | Esophagus | ESCC | 4.09e-15 | 2.97e-01 | 0.116 |
55284 | UBE2W | P11T-E | Human | Esophagus | ESCC | 6.15e-08 | 3.12e-01 | 0.1426 |
55284 | UBE2W | P12T-E | Human | Esophagus | ESCC | 9.06e-11 | 3.06e-01 | 0.1122 |
55284 | UBE2W | P15T-E | Human | Esophagus | ESCC | 9.19e-09 | 2.04e-01 | 0.1149 |
55284 | UBE2W | P16T-E | Human | Esophagus | ESCC | 3.24e-19 | 4.06e-01 | 0.1153 |
55284 | UBE2W | P20T-E | Human | Esophagus | ESCC | 5.37e-12 | 2.12e-01 | 0.1124 |
55284 | UBE2W | P21T-E | Human | Esophagus | ESCC | 1.29e-17 | 3.81e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0035966111 | Esophagus | ESCC | response to topologically incorrect protein | 125/8552 | 159/18723 | 1.44e-17 | 1.27e-15 | 125 |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:0035967111 | Esophagus | ESCC | cellular response to topologically incorrect protein | 90/8552 | 116/18723 | 1.94e-12 | 8.11e-11 | 90 |
GO:00065136 | Esophagus | ESCC | protein monoubiquitination | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:007097912 | Esophagus | ESCC | protein K11-linked ubiquitination | 27/8552 | 29/18723 | 8.09e-08 | 1.39e-06 | 27 |
GO:00517884 | Esophagus | ESCC | response to misfolded protein | 21/8552 | 25/18723 | 9.12e-05 | 6.54e-04 | 21 |
GO:00712184 | Esophagus | ESCC | cellular response to misfolded protein | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00065154 | Esophagus | ESCC | protein quality control for misfolded or incompletely synthesized proteins | 21/8552 | 28/18723 | 1.57e-03 | 7.33e-03 | 21 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
GO:004316112 | Liver | Cirrhotic | proteasome-mediated ubiquitin-dependent protein catabolic process | 184/4634 | 412/18723 | 4.52e-19 | 8.85e-17 | 184 |
GO:00359667 | Liver | Cirrhotic | response to topologically incorrect protein | 91/4634 | 159/18723 | 2.07e-18 | 3.60e-16 | 91 |
GO:00359677 | Liver | Cirrhotic | cellular response to topologically incorrect protein | 64/4634 | 116/18723 | 2.20e-12 | 1.62e-10 | 64 |
GO:000020911 | Liver | Cirrhotic | protein polyubiquitination | 89/4634 | 236/18723 | 6.09e-06 | 9.80e-05 | 89 |
GO:000651511 | Liver | Cirrhotic | protein quality control for misfolded or incompletely synthesized proteins | 16/4634 | 28/18723 | 2.53e-04 | 2.27e-03 | 16 |
GO:0070979 | Liver | Cirrhotic | protein K11-linked ubiquitination | 16/4634 | 29/18723 | 4.36e-04 | 3.55e-03 | 16 |
GO:00517881 | Liver | Cirrhotic | response to misfolded protein | 14/4634 | 25/18723 | 8.15e-04 | 5.95e-03 | 14 |
GO:00712182 | Liver | Cirrhotic | cellular response to misfolded protein | 12/4634 | 23/18723 | 4.23e-03 | 2.24e-02 | 12 |
GO:00065133 | Liver | Cirrhotic | protein monoubiquitination | 26/4634 | 67/18723 | 7.53e-03 | 3.57e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412021 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412031 | Liver | Cirrhotic | Ubiquitin mediated proteolysis | 72/2530 | 142/8465 | 1.32e-07 | 1.97e-06 | 1.21e-06 | 72 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa0412043 | Oral cavity | EOLP | Ubiquitin mediated proteolysis | 48/1218 | 142/8465 | 3.55e-09 | 6.74e-08 | 3.98e-08 | 48 |
hsa0412053 | Oral cavity | EOLP | Ubiquitin mediated proteolysis | 48/1218 | 142/8465 | 3.55e-09 | 6.74e-08 | 3.98e-08 | 48 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE2W | SNV | Missense_Mutation | novel | c.239A>G | p.Asp80Gly | p.D80G | protein_coding | tolerated(0.16) | probably_damaging(0.922) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBE2W | SNV | Missense_Mutation | novel | c.473N>A | p.Ser158Asn | p.S158N | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBE2W | SNV | Missense_Mutation | novel | c.176N>A | p.Pro59Gln | p.P59Q | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
UBE2W | SNV | Missense_Mutation | c.185N>T | p.Gly62Val | p.G62V | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | ||
UBE2W | SNV | Missense_Mutation | c.167N>T | p.Gln56Leu | p.Q56L | protein_coding | tolerated(0.17) | benign(0.027) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
UBE2W | SNV | Missense_Mutation | novel | c.403N>A | p.Leu135Ile | p.L135I | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-22-4594-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
UBE2W | SNV | Missense_Mutation | c.377N>T | p.Ser126Ile | p.S126I | protein_coding | deleterious(0) | possibly_damaging(0.665) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
UBE2W | SNV | Missense_Mutation | c.214N>C | p.Asn72His | p.N72H | protein_coding | deleterious(0.01) | probably_damaging(0.918) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
UBE2W | SNV | Missense_Mutation | novel | c.356N>A | p.Pro119His | p.P119H | protein_coding | deleterious(0.04) | possibly_damaging(0.797) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
UBE2W | SNV | Missense_Mutation | novel | c.385N>G | p.His129Asp | p.H129D | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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