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Gene: UBE2Q1 |
Gene summary for UBE2Q1 |
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Gene information | Species | Human | Gene symbol | UBE2Q1 | Gene ID | 55585 |
Gene name | ubiquitin conjugating enzyme E2 Q1 | |
Gene Alias | GTAP | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q7Z7E8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55585 | UBE2Q1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.10e-05 | 1.54e-01 | 0.0155 |
55585 | UBE2Q1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.91e-03 | 2.22e-01 | -0.1808 |
55585 | UBE2Q1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.40e-06 | 3.24e-01 | -0.0811 |
55585 | UBE2Q1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.53e-04 | 2.13e-01 | -0.1088 |
55585 | UBE2Q1 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.32e-10 | 2.79e-01 | -0.1954 |
55585 | UBE2Q1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.59e-03 | 2.27e-01 | -0.1464 |
55585 | UBE2Q1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.50e-13 | 4.76e-01 | -0.059 |
55585 | UBE2Q1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.08e-04 | 3.82e-01 | -0.2061 |
55585 | UBE2Q1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.47e-04 | 2.78e-01 | -0.0179 |
55585 | UBE2Q1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.32e-15 | 4.27e-01 | 0.096 |
55585 | UBE2Q1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.47e-04 | 3.99e-01 | 0.0131 |
55585 | UBE2Q1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.54e-04 | 1.98e-01 | 0.0338 |
55585 | UBE2Q1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.12e-06 | 3.05e-01 | 0.0674 |
55585 | UBE2Q1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.96e-05 | 3.39e-01 | 0.294 |
55585 | UBE2Q1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.39e-25 | 6.68e-01 | 0.3859 |
55585 | UBE2Q1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.77e-02 | 1.85e-01 | 0.3005 |
55585 | UBE2Q1 | LZE2T | Human | Esophagus | ESCC | 8.46e-03 | 4.72e-01 | 0.082 |
55585 | UBE2Q1 | LZE4T | Human | Esophagus | ESCC | 7.52e-06 | 2.64e-02 | 0.0811 |
55585 | UBE2Q1 | LZE24T | Human | Esophagus | ESCC | 1.52e-05 | 1.69e-01 | 0.0596 |
55585 | UBE2Q1 | LZE6T | Human | Esophagus | ESCC | 8.88e-03 | 6.82e-02 | 0.0845 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0015833 | Colorectum | AD | peptide transport | 77/3918 | 264/18723 | 8.90e-04 | 8.60e-03 | 77 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0030072 | Colorectum | AD | peptide hormone secretion | 68/3918 | 236/18723 | 2.39e-03 | 1.85e-02 | 68 |
GO:0002790 | Colorectum | AD | peptide secretion | 69/3918 | 242/18723 | 2.97e-03 | 2.22e-02 | 69 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
GO:00093061 | Colorectum | SER | protein secretion | 79/2897 | 359/18723 | 5.99e-04 | 8.19e-03 | 79 |
GO:00355921 | Colorectum | SER | establishment of protein localization to extracellular region | 79/2897 | 360/18723 | 6.54e-04 | 8.77e-03 | 79 |
GO:00716921 | Colorectum | SER | protein localization to extracellular region | 80/2897 | 368/18723 | 8.13e-04 | 1.01e-02 | 80 |
GO:00158331 | Colorectum | SER | peptide transport | 58/2897 | 264/18723 | 3.08e-03 | 2.70e-02 | 58 |
GO:00614581 | Colorectum | SER | reproductive system development | 87/2897 | 427/18723 | 3.69e-03 | 3.07e-02 | 87 |
GO:00002092 | Colorectum | MSS | protein polyubiquitination | 72/3467 | 236/18723 | 5.19e-06 | 1.42e-04 | 72 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
GO:00716922 | Colorectum | MSS | protein localization to extracellular region | 99/3467 | 368/18723 | 4.17e-05 | 7.83e-04 | 99 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041202 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa041203 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa041204 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041205 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa0412025 | Oral cavity | LP | Ubiquitin mediated proteolysis | 66/2418 | 142/8465 | 3.74e-06 | 3.46e-05 | 2.23e-05 | 66 |
hsa0412035 | Oral cavity | LP | Ubiquitin mediated proteolysis | 66/2418 | 142/8465 | 3.74e-06 | 3.46e-05 | 2.23e-05 | 66 |
hsa0412018 | Prostate | BPH | Ubiquitin mediated proteolysis | 61/1718 | 142/8465 | 5.50e-10 | 9.07e-09 | 5.61e-09 | 61 |
hsa0412019 | Prostate | BPH | Ubiquitin mediated proteolysis | 61/1718 | 142/8465 | 5.50e-10 | 9.07e-09 | 5.61e-09 | 61 |
hsa0412024 | Prostate | Tumor | Ubiquitin mediated proteolysis | 61/1791 | 142/8465 | 3.08e-09 | 5.09e-08 | 3.16e-08 | 61 |
hsa0412034 | Prostate | Tumor | Ubiquitin mediated proteolysis | 61/1791 | 142/8465 | 3.08e-09 | 5.09e-08 | 3.16e-08 | 61 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE2Q1 | SNV | Missense_Mutation | novel | c.593C>G | p.Thr198Arg | p.T198R | Q7Z7E8 | protein_coding | tolerated(0.4) | benign(0.005) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UBE2Q1 | SNV | Missense_Mutation | c.647A>C | p.Lys216Thr | p.K216T | Q7Z7E8 | protein_coding | deleterious(0.05) | benign(0.141) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UBE2Q1 | SNV | Missense_Mutation | c.578N>C | p.Glu193Ala | p.E193A | Q7Z7E8 | protein_coding | deleterious(0.03) | benign(0.269) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
UBE2Q1 | SNV | Missense_Mutation | c.1045G>A | p.Ala349Thr | p.A349T | Q7Z7E8 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD | |
UBE2Q1 | SNV | Missense_Mutation | c.829N>A | p.Glu277Lys | p.E277K | Q7Z7E8 | protein_coding | deleterious(0) | possibly_damaging(0.581) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
UBE2Q1 | SNV | Missense_Mutation | rs754369992 | c.1228G>A | p.Glu410Lys | p.E410K | Q7Z7E8 | protein_coding | tolerated(0.07) | benign(0.234) | TCGA-G4-6314-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD |
UBE2Q1 | SNV | Missense_Mutation | c.308N>A | p.Arg103His | p.R103H | Q7Z7E8 | protein_coding | tolerated(0.15) | benign(0.01) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UBE2Q1 | SNV | Missense_Mutation | novel | c.937N>A | p.Asp313Asn | p.D313N | Q7Z7E8 | protein_coding | deleterious(0.04) | possibly_damaging(0.901) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
UBE2Q1 | insertion | Frame_Shift_Ins | novel | c.1235dupA | p.Asn412LysfsTer31 | p.N412Kfs*31 | Q7Z7E8 | protein_coding | TCGA-D5-5537-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
UBE2Q1 | deletion | Frame_Shift_Del | c.278delC | p.Pro93HisfsTer46 | p.P93Hfs*46 | Q7Z7E8 | protein_coding | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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