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Gene: UBA1 |
Gene summary for UBA1 |
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Gene information | Species | Human | Gene symbol | UBA1 | Gene ID | 7317 |
Gene name | ubiquitin like modifier activating enzyme 1 | |
Gene Alias | A1S9 | |
Cytomap | Xp11.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | A0A024R1A3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7317 | UBA1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.45e-07 | 2.35e-01 | 0.0155 |
7317 | UBA1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.21e-32 | 1.01e+00 | -0.1808 |
7317 | UBA1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.76e-03 | 5.49e-01 | 0.0216 |
7317 | UBA1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.02e-20 | 7.79e-01 | -0.0811 |
7317 | UBA1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.61e-17 | 5.47e-01 | -0.1088 |
7317 | UBA1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.15e-34 | 7.72e-01 | -0.1954 |
7317 | UBA1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.39e-16 | 1.74e+00 | -0.2602 |
7317 | UBA1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.76e-06 | 9.27e-01 | -0.2196 |
7317 | UBA1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.83e-10 | 5.80e-01 | -0.1207 |
7317 | UBA1 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.57e-12 | 5.39e-01 | -0.1526 |
7317 | UBA1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.08e-28 | 7.48e-01 | -0.1464 |
7317 | UBA1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.32e-05 | 3.71e-01 | -0.1001 |
7317 | UBA1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.44e-30 | 9.97e-01 | -0.059 |
7317 | UBA1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.65e-06 | 6.36e-01 | -0.1706 |
7317 | UBA1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.22e-07 | 5.85e-01 | -0.2061 |
7317 | UBA1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.61e-09 | 7.47e-01 | -0.1462 |
7317 | UBA1 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.84e-12 | 5.69e-01 | -0.0842 |
7317 | UBA1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.25e-03 | 2.42e-01 | -0.0179 |
7317 | UBA1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.99e-19 | 5.18e-01 | 0.096 |
7317 | UBA1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.74e-04 | 3.96e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00307057 | Cervix | CC | cytoskeleton-dependent intracellular transport | 40/2311 | 195/18723 | 7.92e-04 | 6.99e-03 | 40 |
GO:00713533 | Cervix | HSIL_HPV | cellular response to interleukin-4 | 7/737 | 33/18723 | 2.48e-04 | 4.30e-03 | 7 |
GO:00706703 | Cervix | HSIL_HPV | response to interleukin-4 | 7/737 | 36/18723 | 4.38e-04 | 6.51e-03 | 7 |
GO:003070513 | Cervix | N_HPV | cytoskeleton-dependent intracellular transport | 13/534 | 195/18723 | 4.03e-03 | 3.16e-02 | 13 |
GO:00307058 | Endometrium | AEH | cytoskeleton-dependent intracellular transport | 38/2100 | 195/18723 | 4.72e-04 | 4.91e-03 | 38 |
GO:00508086 | Endometrium | AEH | synapse organization | 67/2100 | 426/18723 | 2.67e-03 | 1.94e-02 | 67 |
GO:003070514 | Endometrium | EEC | cytoskeleton-dependent intracellular transport | 39/2168 | 195/18723 | 4.40e-04 | 4.58e-03 | 39 |
GO:005080812 | Endometrium | EEC | synapse organization | 68/2168 | 426/18723 | 3.73e-03 | 2.49e-02 | 68 |
GO:003070517 | Esophagus | HGIN | cytoskeleton-dependent intracellular transport | 45/2587 | 195/18723 | 3.07e-04 | 5.15e-03 | 45 |
GO:003070518 | Esophagus | ESCC | cytoskeleton-dependent intracellular transport | 133/8552 | 195/18723 | 1.48e-10 | 4.27e-09 | 133 |
GO:00713532 | Liver | Cirrhotic | cellular response to interleukin-4 | 17/4634 | 33/18723 | 8.32e-04 | 6.06e-03 | 17 |
GO:003070511 | Liver | Cirrhotic | cytoskeleton-dependent intracellular transport | 68/4634 | 195/18723 | 9.54e-04 | 6.77e-03 | 68 |
GO:00706702 | Liver | Cirrhotic | response to interleukin-4 | 17/4634 | 36/18723 | 2.82e-03 | 1.63e-02 | 17 |
GO:003070521 | Liver | HCC | cytoskeleton-dependent intracellular transport | 111/7958 | 195/18723 | 3.25e-05 | 3.28e-04 | 111 |
GO:007135311 | Liver | HCC | cellular response to interleukin-4 | 21/7958 | 33/18723 | 1.16e-02 | 4.28e-02 | 21 |
GO:003070510 | Oral cavity | OSCC | cytoskeleton-dependent intracellular transport | 113/7305 | 195/18723 | 6.03e-08 | 1.09e-06 | 113 |
GO:00713535 | Oral cavity | OSCC | cellular response to interleukin-4 | 21/7305 | 33/18723 | 3.63e-03 | 1.51e-02 | 21 |
GO:00706705 | Oral cavity | OSCC | response to interleukin-4 | 21/7305 | 36/18723 | 1.46e-02 | 4.76e-02 | 21 |
GO:007135313 | Oral cavity | LP | cellular response to interleukin-4 | 18/4623 | 33/18723 | 2.26e-04 | 2.41e-03 | 18 |
GO:003070516 | Oral cavity | LP | cytoskeleton-dependent intracellular transport | 68/4623 | 195/18723 | 8.92e-04 | 7.64e-03 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05012 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa050121 | Colorectum | AD | Parkinson disease | 147/2092 | 266/8465 | 2.53e-27 | 8.48e-25 | 5.41e-25 | 147 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa050122 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050222 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa041202 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa050123 | Colorectum | SER | Parkinson disease | 132/1580 | 266/8465 | 2.72e-31 | 9.03e-29 | 6.55e-29 | 132 |
hsa050223 | Colorectum | SER | Pathways of neurodegeneration - multiple diseases | 168/1580 | 476/8465 | 6.23e-19 | 2.07e-17 | 1.50e-17 | 168 |
hsa041203 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa050124 | Colorectum | MSS | Parkinson disease | 140/1875 | 266/8465 | 2.32e-28 | 7.79e-26 | 4.77e-26 | 140 |
hsa050224 | Colorectum | MSS | Pathways of neurodegeneration - multiple diseases | 192/1875 | 476/8465 | 2.79e-20 | 1.04e-18 | 6.36e-19 | 192 |
hsa041204 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa050125 | Colorectum | MSS | Parkinson disease | 140/1875 | 266/8465 | 2.32e-28 | 7.79e-26 | 4.77e-26 | 140 |
hsa050225 | Colorectum | MSS | Pathways of neurodegeneration - multiple diseases | 192/1875 | 476/8465 | 2.79e-20 | 1.04e-18 | 6.36e-19 | 192 |
hsa041205 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa050126 | Colorectum | MSI-H | Parkinson disease | 85/797 | 266/8465 | 1.19e-25 | 1.29e-23 | 1.08e-23 | 85 |
hsa050226 | Colorectum | MSI-H | Pathways of neurodegeneration - multiple diseases | 107/797 | 476/8465 | 1.24e-18 | 5.72e-17 | 4.80e-17 | 107 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBA1 | SNV | Missense_Mutation | novel | c.658A>T | p.Met220Leu | p.M220L | P22314 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UBA1 | SNV | Missense_Mutation | c.2413N>A | p.Val805Ile | p.V805I | P22314 | protein_coding | tolerated(0.1) | benign(0.042) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
UBA1 | SNV | Missense_Mutation | novel | c.241N>T | p.Arg81Trp | p.R81W | P22314 | protein_coding | deleterious(0) | possibly_damaging(0.72) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UBA1 | SNV | Missense_Mutation | c.2309N>G | p.Asn770Ser | p.N770S | P22314 | protein_coding | deleterious(0.04) | probably_damaging(0.993) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UBA1 | SNV | Missense_Mutation | c.1022N>T | p.Ala341Val | p.A341V | P22314 | protein_coding | tolerated(0.2) | benign(0.021) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBA1 | SNV | Missense_Mutation | c.2824N>A | p.Ala942Thr | p.A942T | P22314 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBA1 | SNV | Missense_Mutation | c.109N>T | p.Pro37Ser | p.P37S | P22314 | protein_coding | tolerated(0.29) | benign(0) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UBA1 | SNV | Missense_Mutation | c.2413N>A | p.Val805Ile | p.V805I | P22314 | protein_coding | tolerated(0.1) | benign(0.042) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
UBA1 | SNV | Missense_Mutation | c.2077C>A | p.Arg693Ser | p.R693S | P22314 | protein_coding | tolerated(0.83) | benign(0.029) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UBA1 | SNV | Missense_Mutation | c.1001A>T | p.Gln334Leu | p.Q334L | P22314 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-F4-6807-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7317 | UBA1 | ENZYME | HYRTIOERECTINE B | HYRTIOERECTINE B | 22695182 | |
7317 | UBA1 | ENZYME | HIMEIC ACID A | HIMEIC ACID A | 22695182 |
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