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Gene: TXNDC5 |
Gene summary for TXNDC5 |
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Gene information | Species | Human | Gene symbol | TXNDC5 | Gene ID | 81567 |
Gene name | thioredoxin domain containing 5 | |
Gene Alias | ENDOPDI | |
Cytomap | 6p24.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024QZV0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81567 | TXNDC5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.38e-10 | 2.03e-01 | 0.0155 |
81567 | TXNDC5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.80e-07 | 2.50e-01 | -0.1808 |
81567 | TXNDC5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.04e-15 | 4.80e-01 | -0.0811 |
81567 | TXNDC5 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.63e-17 | 4.49e-01 | -0.1088 |
81567 | TXNDC5 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.10e-17 | 3.32e-01 | -0.1954 |
81567 | TXNDC5 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 3.31e-01 | -0.2602 |
81567 | TXNDC5 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.50e-04 | 3.37e-01 | -0.2196 |
81567 | TXNDC5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-03 | 2.02e-01 | -0.1207 |
81567 | TXNDC5 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.64e-05 | 2.18e-01 | -0.1526 |
81567 | TXNDC5 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.73e-12 | 2.80e-01 | -0.1464 |
81567 | TXNDC5 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.05e-06 | 1.89e-01 | -0.1001 |
81567 | TXNDC5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.53e-27 | 7.20e-01 | -0.059 |
81567 | TXNDC5 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 2.63e-01 | -0.1706 |
81567 | TXNDC5 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.22e-01 | -0.1462 |
81567 | TXNDC5 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.71e-06 | 5.79e-01 | -0.0842 |
81567 | TXNDC5 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.61e-03 | 2.55e-01 | -0.00410000000000005 |
81567 | TXNDC5 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-06 | 2.70e-01 | -0.0179 |
81567 | TXNDC5 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.23e-22 | 4.77e-01 | 0.096 |
81567 | TXNDC5 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.51e-11 | 4.41e-01 | 0.0446 |
81567 | TXNDC5 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 2.67e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041416 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa041417 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXNDC5 | SNV | Missense_Mutation | rs754952152 | c.401N>A | p.Arg134Gln | p.R134Q | Q8NBS9 | protein_coding | tolerated(0.16) | probably_damaging(0.999) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNDC5 | SNV | Missense_Mutation | rs755607324 | c.644C>T | p.Pro215Leu | p.P215L | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TXNDC5 | SNV | Missense_Mutation | rs530530741 | c.1291N>A | p.Glu431Lys | p.E431K | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TXNDC5 | SNV | Missense_Mutation | rs758889890 | c.640G>A | p.Ala214Thr | p.A214T | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNDC5 | SNV | Missense_Mutation | c.931N>T | p.Pro311Ser | p.P311S | Q8NBS9 | protein_coding | tolerated(0.14) | benign(0.184) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TXNDC5 | SNV | Missense_Mutation | novel | c.280N>T | p.Arg94Trp | p.R94W | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNDC5 | SNV | Missense_Mutation | novel | c.388G>A | p.Ala130Thr | p.A130T | Q8NBS9 | protein_coding | tolerated(0.2) | benign(0.37) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNDC5 | SNV | Missense_Mutation | rs777294913 | c.1175N>T | p.Ser392Leu | p.S392L | Q8NBS9 | protein_coding | deleterious(0.02) | possibly_damaging(0.885) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
TXNDC5 | SNV | Missense_Mutation | rs746591819 | c.778C>T | p.Arg260Cys | p.R260C | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNDC5 | SNV | Missense_Mutation | rs530530741 | c.1291N>A | p.Glu431Lys | p.E431K | Q8NBS9 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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