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Gene: TXNDC11 |
Gene summary for TXNDC11 |
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Gene information | Species | Human | Gene symbol | TXNDC11 | Gene ID | 51061 |
Gene name | thioredoxin domain containing 11 | |
Gene Alias | EFP1 | |
Cytomap | 16p13.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6PKC3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51061 | TXNDC11 | LZE4T | Human | Esophagus | ESCC | 3.53e-03 | 8.08e-02 | 0.0811 |
51061 | TXNDC11 | LZE7T | Human | Esophagus | ESCC | 4.67e-03 | 1.85e-01 | 0.0667 |
51061 | TXNDC11 | LZE22T | Human | Esophagus | ESCC | 3.28e-02 | 3.08e-01 | 0.068 |
51061 | TXNDC11 | LZE24T | Human | Esophagus | ESCC | 5.20e-12 | 3.51e-01 | 0.0596 |
51061 | TXNDC11 | LZE21T | Human | Esophagus | ESCC | 7.30e-07 | 2.84e-01 | 0.0655 |
51061 | TXNDC11 | P1T-E | Human | Esophagus | ESCC | 2.17e-11 | 6.94e-01 | 0.0875 |
51061 | TXNDC11 | P2T-E | Human | Esophagus | ESCC | 7.83e-32 | 5.69e-01 | 0.1177 |
51061 | TXNDC11 | P4T-E | Human | Esophagus | ESCC | 1.74e-12 | 3.56e-01 | 0.1323 |
51061 | TXNDC11 | P5T-E | Human | Esophagus | ESCC | 1.13e-14 | 2.41e-01 | 0.1327 |
51061 | TXNDC11 | P8T-E | Human | Esophagus | ESCC | 3.31e-19 | 3.79e-01 | 0.0889 |
51061 | TXNDC11 | P9T-E | Human | Esophagus | ESCC | 6.54e-12 | 2.51e-01 | 0.1131 |
51061 | TXNDC11 | P10T-E | Human | Esophagus | ESCC | 8.18e-16 | 1.52e-01 | 0.116 |
51061 | TXNDC11 | P11T-E | Human | Esophagus | ESCC | 1.98e-11 | 6.35e-01 | 0.1426 |
51061 | TXNDC11 | P12T-E | Human | Esophagus | ESCC | 4.92e-37 | 5.64e-01 | 0.1122 |
51061 | TXNDC11 | P15T-E | Human | Esophagus | ESCC | 8.34e-19 | 3.00e-01 | 0.1149 |
51061 | TXNDC11 | P16T-E | Human | Esophagus | ESCC | 2.27e-23 | 3.48e-01 | 0.1153 |
51061 | TXNDC11 | P17T-E | Human | Esophagus | ESCC | 2.84e-04 | 1.88e-01 | 0.1278 |
51061 | TXNDC11 | P20T-E | Human | Esophagus | ESCC | 1.58e-38 | 1.03e+00 | 0.1124 |
51061 | TXNDC11 | P21T-E | Human | Esophagus | ESCC | 1.65e-18 | 2.83e-01 | 0.1617 |
51061 | TXNDC11 | P22T-E | Human | Esophagus | ESCC | 6.80e-14 | 2.51e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXNDC11 | SNV | Missense_Mutation | rs765281874 | c.1307C>T | p.Pro436Leu | p.P436L | Q6PKC3 | protein_coding | tolerated(0.25) | benign(0.053) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TXNDC11 | SNV | Missense_Mutation | novel | c.1560N>A | p.Ser520Arg | p.S520R | Q6PKC3 | protein_coding | deleterious(0.01) | possibly_damaging(0.798) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
TXNDC11 | SNV | Missense_Mutation | c.2516C>T | p.Ala839Val | p.A839V | Q6PKC3 | protein_coding | tolerated(0.07) | benign(0.276) | TCGA-FU-A3EO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TXNDC11 | SNV | Missense_Mutation | c.685N>A | p.Leu229Ile | p.L229I | Q6PKC3 | protein_coding | deleterious(0.03) | possibly_damaging(0.471) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TXNDC11 | SNV | Missense_Mutation | novel | c.819N>T | p.Arg273Ser | p.R273S | Q6PKC3 | protein_coding | tolerated_low_confidence(0.24) | benign(0.003) | TCGA-VS-A9UY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
TXNDC11 | SNV | Missense_Mutation | c.959N>T | p.Tyr320Phe | p.Y320F | Q6PKC3 | protein_coding | deleterious(0.05) | benign(0.132) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TXNDC11 | SNV | Missense_Mutation | rs780914402 | c.1490C>T | p.Ala497Val | p.A497V | Q6PKC3 | protein_coding | deleterious(0.03) | benign(0.058) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TXNDC11 | SNV | Missense_Mutation | c.2943N>T | p.Glu981Asp | p.E981D | Q6PKC3 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.527) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TXNDC11 | SNV | Missense_Mutation | novel | c.1919A>C | p.Asp640Ala | p.D640A | Q6PKC3 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
TXNDC11 | SNV | Missense_Mutation | c.917A>C | p.His306Pro | p.H306P | Q6PKC3 | protein_coding | deleterious(0.04) | benign(0.268) | TCGA-AZ-5403-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51061 | TXNDC11 | DRUGGABLE GENOME, THIOREDOXIN | hydrochlorothiazide | HYDROCHLOROTHIAZIDE |
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