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Gene: TSTA3 |
Gene summary for TSTA3 |
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Gene information | Species | Human | Gene symbol | TSTA3 | Gene ID | 7264 |
Gene name | GDP-L-fucose synthase | |
Gene Alias | FX | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | Q13630 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7264 | TSTA3 | GSM4909281 | Human | Breast | IDC | 1.98e-02 | 2.54e-01 | 0.21 |
7264 | TSTA3 | GSM4909285 | Human | Breast | IDC | 2.25e-25 | 6.35e-01 | 0.21 |
7264 | TSTA3 | GSM4909294 | Human | Breast | IDC | 4.35e-12 | 5.92e-01 | 0.2022 |
7264 | TSTA3 | GSM4909296 | Human | Breast | IDC | 6.64e-15 | 4.82e-01 | 0.1524 |
7264 | TSTA3 | GSM4909297 | Human | Breast | IDC | 8.02e-04 | 3.97e-02 | 0.1517 |
7264 | TSTA3 | GSM4909304 | Human | Breast | IDC | 2.68e-21 | 6.48e-01 | 0.1636 |
7264 | TSTA3 | GSM4909308 | Human | Breast | IDC | 5.68e-06 | 3.27e-01 | 0.158 |
7264 | TSTA3 | GSM4909311 | Human | Breast | IDC | 2.92e-20 | 2.76e-01 | 0.1534 |
7264 | TSTA3 | GSM4909312 | Human | Breast | IDC | 1.22e-21 | 6.54e-01 | 0.1552 |
7264 | TSTA3 | GSM4909317 | Human | Breast | IDC | 2.24e-22 | 6.36e-01 | 0.1355 |
7264 | TSTA3 | GSM4909319 | Human | Breast | IDC | 9.28e-26 | 6.37e-02 | 0.1563 |
7264 | TSTA3 | GSM4909320 | Human | Breast | IDC | 3.72e-02 | 1.57e-02 | 0.1575 |
7264 | TSTA3 | GSM4909321 | Human | Breast | IDC | 1.50e-08 | 2.36e-01 | 0.1559 |
7264 | TSTA3 | brca1 | Human | Breast | Precancer | 1.54e-09 | 4.46e-01 | -0.0338 |
7264 | TSTA3 | NCCBC11 | Human | Breast | DCIS | 3.07e-02 | 3.53e-01 | 0.1232 |
7264 | TSTA3 | NCCBC14 | Human | Breast | DCIS | 4.95e-08 | 4.06e-01 | 0.2021 |
7264 | TSTA3 | NCCBC2 | Human | Breast | DCIS | 4.55e-02 | 3.46e-02 | 0.1554 |
7264 | TSTA3 | NCCBC5 | Human | Breast | DCIS | 1.13e-08 | 1.67e-01 | 0.2046 |
7264 | TSTA3 | NCCBC6 | Human | Breast | DCIS | 2.05e-04 | 4.66e-01 | 0.2095 |
7264 | TSTA3 | P1 | Human | Breast | IDC | 1.29e-03 | -7.06e-02 | 0.1527 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSTA3 | SNV | Missense_Mutation | novel | c.911C>T | p.Ala304Val | p.A304V | Q13630 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
TSTA3 | SNV | Missense_Mutation | novel | c.541N>T | p.Asn181Tyr | p.N181Y | Q13630 | protein_coding | deleterious(0) | possibly_damaging(0.654) | TCGA-DD-AACQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TSTA3 | SNV | Missense_Mutation | novel | c.799N>T | p.Gly267Trp | p.G267W | Q13630 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-68-A59J-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSTA3 | SNV | Missense_Mutation | c.798N>A | p.His266Gln | p.H266Q | Q13630 | protein_coding | tolerated(0.3) | benign(0) | TCGA-68-A59J-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSTA3 | SNV | Missense_Mutation | rs368480990 | c.624N>C | p.Trp208Cys | p.W208C | Q13630 | protein_coding | tolerated(0.08) | benign(0.112) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TSTA3 | SNV | Missense_Mutation | novel | c.279G>T | p.Met93Ile | p.M93I | Q13630 | protein_coding | tolerated(1) | benign(0) | TCGA-CV-5434-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
TSTA3 | SNV | Missense_Mutation | rs138619385 | c.409N>A | p.His137Asn | p.H137N | Q13630 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CV-7238-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSTA3 | SNV | Missense_Mutation | c.449N>G | p.Ile150Ser | p.I150S | Q13630 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-CH-5754-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | |
TSTA3 | SNV | Missense_Mutation | c.374N>A | p.Pro125Gln | p.P125Q | Q13630 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
TSTA3 | SNV | Missense_Mutation | novel | c.920A>G | p.Glu307Gly | p.E307G | Q13630 | protein_coding | deleterious(0.03) | benign(0.266) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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