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Gene: TSPAN2 |
Gene summary for TSPAN2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TSPAN2 | Gene ID | 10100 |
Gene name | tetraspanin 2 | |
Gene Alias | NET3 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | B1AKP1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10100 | TSPAN2 | P2T-E | Human | Esophagus | ESCC | 3.58e-28 | 3.90e-01 | 0.1177 |
10100 | TSPAN2 | P5T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.92e-01 | 0.1327 |
10100 | TSPAN2 | P10T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.94e-01 | 0.116 |
10100 | TSPAN2 | P11T-E | Human | Esophagus | ESCC | 2.46e-02 | 1.39e-01 | 0.1426 |
10100 | TSPAN2 | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.29e-01 | 0.1153 |
10100 | TSPAN2 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 6.89e-01 | 0.1662 |
10100 | TSPAN2 | P21T-E | Human | Esophagus | ESCC | 2.28e-35 | 8.89e-01 | 0.1617 |
10100 | TSPAN2 | P31T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.36e-01 | 0.1251 |
10100 | TSPAN2 | P32T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.54e-01 | 0.1666 |
10100 | TSPAN2 | P37T-E | Human | Esophagus | ESCC | 4.27e-06 | 2.01e-01 | 0.1371 |
10100 | TSPAN2 | P56T-E | Human | Esophagus | ESCC | 5.84e-10 | 6.29e-01 | 0.1613 |
10100 | TSPAN2 | P57T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.03e-01 | 0.0926 |
10100 | TSPAN2 | P61T-E | Human | Esophagus | ESCC | 4.84e-16 | 4.02e-01 | 0.099 |
10100 | TSPAN2 | P74T-E | Human | Esophagus | ESCC | 3.23e-09 | 2.96e-01 | 0.1479 |
10100 | TSPAN2 | P75T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.57e-01 | 0.1125 |
10100 | TSPAN2 | P76T-E | Human | Esophagus | ESCC | 1.62e-13 | 3.49e-01 | 0.1207 |
10100 | TSPAN2 | P79T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.71e-01 | 0.1154 |
10100 | TSPAN2 | P83T-E | Human | Esophagus | ESCC | 3.17e-02 | 1.08e-01 | 0.1738 |
10100 | TSPAN2 | P130T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.10e-01 | 0.1676 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030099111 | Esophagus | ESCC | myeloid cell differentiation | 232/8552 | 381/18723 | 1.22e-09 | 2.90e-08 | 232 |
GO:000257317 | Esophagus | ESCC | myeloid leukocyte differentiation | 128/8552 | 208/18723 | 2.75e-06 | 3.15e-05 | 128 |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:00487092 | Esophagus | ESCC | oligodendrocyte differentiation | 55/8552 | 95/18723 | 1.10e-02 | 3.72e-02 | 55 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSPAN2 | SNV | Missense_Mutation | rs200979737 | c.653G>A | p.Arg218Gln | p.R218Q | O60636 | protein_coding | tolerated(0.07) | benign(0.033) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN2 | SNV | Missense_Mutation | rs776668126 | c.526G>A | p.Asp176Asn | p.D176N | O60636 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN2 | SNV | Missense_Mutation | rs201998736 | c.214G>A | p.Val72Met | p.V72M | O60636 | protein_coding | tolerated(0.06) | possibly_damaging(0.458) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN2 | SNV | Missense_Mutation | c.521N>A | p.Cys174Tyr | p.C174Y | O60636 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSPAN2 | SNV | Missense_Mutation | rs777153817 | c.644N>A | p.Arg215Gln | p.R215Q | O60636 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TSPAN2 | SNV | Missense_Mutation | novel | c.298N>A | p.Ala100Thr | p.A100T | O60636 | protein_coding | deleterious(0.02) | probably_damaging(0.942) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN2 | SNV | Missense_Mutation | novel | c.243N>A | p.Met81Ile | p.M81I | O60636 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN2 | SNV | Missense_Mutation | rs776668126 | c.526N>A | p.Asp176Asn | p.D176N | O60636 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TSPAN2 | SNV | Missense_Mutation | novel | c.335G>A | p.Gly112Asp | p.G112D | O60636 | protein_coding | deleterious(0.01) | benign(0.272) | TCGA-B5-A11P-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSPAN2 | SNV | Missense_Mutation | rs575948620 | c.638N>T | p.Ala213Val | p.A213V | O60636 | protein_coding | deleterious(0.03) | benign(0.296) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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