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Gene: TSPAN13 |
Gene summary for TSPAN13 |
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Gene information | Species | Human | Gene symbol | TSPAN13 | Gene ID | 27075 |
Gene name | tetraspanin 13 | |
Gene Alias | NET-6 | |
Cytomap | 7p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O95857 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27075 | TSPAN13 | GSM4909281 | Human | Breast | IDC | 3.52e-03 | 2.80e-01 | 0.21 |
27075 | TSPAN13 | GSM4909286 | Human | Breast | IDC | 2.30e-04 | -2.23e-01 | 0.1081 |
27075 | TSPAN13 | GSM4909290 | Human | Breast | IDC | 3.00e-07 | 4.02e-01 | 0.2096 |
27075 | TSPAN13 | GSM4909296 | Human | Breast | IDC | 5.73e-05 | -1.01e-01 | 0.1524 |
27075 | TSPAN13 | GSM4909297 | Human | Breast | IDC | 2.78e-09 | 2.54e-01 | 0.1517 |
27075 | TSPAN13 | GSM4909298 | Human | Breast | IDC | 5.91e-25 | 6.60e-01 | 0.1551 |
27075 | TSPAN13 | GSM4909302 | Human | Breast | IDC | 1.05e-03 | 2.59e-01 | 0.1545 |
27075 | TSPAN13 | GSM4909304 | Human | Breast | IDC | 2.94e-14 | 5.40e-01 | 0.1636 |
27075 | TSPAN13 | GSM4909306 | Human | Breast | IDC | 1.45e-07 | 4.34e-01 | 0.1564 |
27075 | TSPAN13 | GSM4909307 | Human | Breast | IDC | 3.63e-05 | 3.96e-01 | 0.1569 |
27075 | TSPAN13 | GSM4909308 | Human | Breast | IDC | 2.94e-84 | 1.12e+00 | 0.158 |
27075 | TSPAN13 | GSM4909311 | Human | Breast | IDC | 1.40e-22 | -1.51e-01 | 0.1534 |
27075 | TSPAN13 | GSM4909312 | Human | Breast | IDC | 7.10e-13 | 4.26e-01 | 0.1552 |
27075 | TSPAN13 | GSM4909313 | Human | Breast | IDC | 2.17e-07 | 3.35e-01 | 0.0391 |
27075 | TSPAN13 | GSM4909315 | Human | Breast | IDC | 4.55e-27 | 6.93e-01 | 0.21 |
27075 | TSPAN13 | GSM4909316 | Human | Breast | IDC | 1.04e-20 | 7.08e-01 | 0.21 |
27075 | TSPAN13 | GSM4909317 | Human | Breast | IDC | 1.73e-05 | 3.43e-01 | 0.1355 |
27075 | TSPAN13 | GSM4909318 | Human | Breast | IDC | 1.17e-03 | 4.01e-01 | 0.2031 |
27075 | TSPAN13 | GSM4909319 | Human | Breast | IDC | 1.56e-28 | -1.51e-01 | 0.1563 |
27075 | TSPAN13 | GSM4909321 | Human | Breast | IDC | 1.29e-27 | 6.34e-01 | 0.1559 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00109596 | Breast | Precancer | regulation of metal ion transport | 37/1080 | 406/18723 | 4.07e-03 | 3.22e-02 | 37 |
GO:001095913 | Breast | IDC | regulation of metal ion transport | 52/1434 | 406/18723 | 1.76e-04 | 2.97e-03 | 52 |
GO:0051924 | Breast | IDC | regulation of calcium ion transport | 32/1434 | 255/18723 | 3.94e-03 | 3.22e-02 | 32 |
GO:001095921 | Breast | DCIS | regulation of metal ion transport | 50/1390 | 406/18723 | 2.86e-04 | 4.22e-03 | 50 |
GO:0010959 | Colorectum | FAP | regulation of metal ion transport | 83/2622 | 406/18723 | 2.06e-04 | 2.96e-03 | 83 |
GO:1904062 | Colorectum | FAP | regulation of cation transmembrane transport | 69/2622 | 357/18723 | 3.06e-03 | 2.30e-02 | 69 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSPAN13 | SNV | Missense_Mutation | novel | c.592G>A | p.Ala198Thr | p.A198T | O95857 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
TSPAN13 | insertion | Frame_Shift_Ins | novel | c.584_585insC | p.Arg197ProfsTer5 | p.R197Pfs*5 | O95857 | protein_coding | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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