GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:1904951111 | Esophagus | ESCC | positive regulation of establishment of protein localization | 216/8552 | 319/18723 | 1.01e-15 | 6.86e-14 | 216 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:0051222111 | Esophagus | ESCC | positive regulation of protein transport | 204/8552 | 303/18723 | 1.56e-14 | 8.38e-13 | 204 |
GO:0000302111 | Esophagus | ESCC | response to reactive oxygen species | 150/8552 | 222/18723 | 3.06e-11 | 1.02e-09 | 150 |
GO:0042542111 | Esophagus | ESCC | response to hydrogen peroxide | 102/8552 | 146/18723 | 2.64e-09 | 5.81e-08 | 102 |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:003461420 | Esophagus | ESCC | cellular response to reactive oxygen species | 103/8552 | 155/18723 | 1.34e-07 | 2.17e-06 | 103 |
GO:0009408110 | Esophagus | ESCC | response to heat | 77/8552 | 110/18723 | 2.01e-07 | 3.11e-06 | 77 |
GO:0032970111 | Esophagus | ESCC | regulation of actin filament-based process | 231/8552 | 397/18723 | 2.91e-07 | 4.20e-06 | 231 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
GO:00703018 | Esophagus | ESCC | cellular response to hydrogen peroxide | 68/8552 | 98/18723 | 1.70e-06 | 2.03e-05 | 68 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:003153218 | Esophagus | ESCC | actin cytoskeleton reorganization | 72/8552 | 107/18723 | 5.03e-06 | 5.31e-05 | 72 |
GO:1901216111 | Esophagus | ESCC | positive regulation of neuron death | 65/8552 | 97/18723 | 1.76e-05 | 1.56e-04 | 65 |
GO:001003827 | Esophagus | ESCC | response to metal ion | 208/8552 | 373/18723 | 5.02e-05 | 3.90e-04 | 208 |
GO:0051651111 | Esophagus | ESCC | maintenance of location in cell | 126/8552 | 214/18723 | 6.57e-05 | 5.00e-04 | 126 |
GO:000926619 | Esophagus | ESCC | response to temperature stimulus | 106/8552 | 178/18723 | 1.30e-04 | 8.84e-04 | 106 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0462122 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa0462132 | Esophagus | ESCC | NOD-like receptor signaling pathway | 116/4205 | 186/8465 | 2.90e-04 | 1.03e-03 | 5.30e-04 | 116 |
hsa046218 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462113 | Oral cavity | OSCC | NOD-like receptor signaling pathway | 108/3704 | 186/8465 | 5.13e-05 | 2.07e-04 | 1.05e-04 | 108 |
hsa0462121 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa0462131 | Oral cavity | LP | NOD-like receptor signaling pathway | 73/2418 | 186/8465 | 9.80e-04 | 4.53e-03 | 2.92e-03 | 73 |
hsa046214 | Oral cavity | EOLP | NOD-like receptor signaling pathway | 48/1218 | 186/8465 | 2.51e-05 | 1.31e-04 | 7.70e-05 | 48 |
hsa049219 | Oral cavity | EOLP | Oxytocin signaling pathway | 36/1218 | 154/8465 | 1.79e-03 | 6.08e-03 | 3.58e-03 | 36 |
hsa046215 | Oral cavity | EOLP | NOD-like receptor signaling pathway | 48/1218 | 186/8465 | 2.51e-05 | 1.31e-04 | 7.70e-05 | 48 |
hsa0492112 | Oral cavity | EOLP | Oxytocin signaling pathway | 36/1218 | 154/8465 | 1.79e-03 | 6.08e-03 | 3.58e-03 | 36 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRPM2 | SNV | Missense_Mutation | novel | c.790N>C | p.Tyr264His | p.Y264H | | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRPM2 | SNV | Missense_Mutation | novel | c.4330N>A | p.Pro1444Thr | p.P1444T | | protein_coding | deleterious(0.01) | benign(0.283) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRPM2 | SNV | Missense_Mutation | rs764271519 | c.1115N>T | p.Ser372Leu | p.S372L | | protein_coding | deleterious(0.02) | benign(0.436) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRPM2 | SNV | Missense_Mutation | | c.1021G>T | p.Asp341Tyr | p.D341Y | | protein_coding | tolerated(1) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRPM2 | SNV | Missense_Mutation | rs376205676 | c.2793N>A | p.Met931Ile | p.M931I | | protein_coding | tolerated(0.07) | benign(0.397) | TCGA-JX-A3Q8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRPM2 | SNV | Missense_Mutation | novel | c.1708N>T | p.Gly570Trp | p.G570W | | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-UC-A7PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
TRPM2 | deletion | In_Frame_Del | novel | c.1297_1308delATCTTGCAGGCC | p.Ile433_Ala436del | p.I433_A436del | | protein_coding | | | TCGA-EK-A2H0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRPM2 | deletion | In_Frame_Del | novel | c.1297_1308delATCTTGCAGGCC | p.Ile433_Ala436del | p.I433_A436del | | protein_coding | | | TCGA-ZJ-A8QQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TRPM2 | SNV | Missense_Mutation | | c.2896C>A | p.Leu966Met | p.L966M | | protein_coding | deleterious(0.04) | possibly_damaging(0.609) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TRPM2 | SNV | Missense_Mutation | rs138507862 | c.1067N>T | p.Ser356Leu | p.S356L | | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3527-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650269 | | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 135651442 | | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178102951 | | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 53801022 | | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650220 | ECONAZOLE | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 135652736 | | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135652738 | | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | activator | 178101017 | | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 135650114 | CLOTRIMAZOLE | |
7226 | TRPM2 | ION CHANNEL, DRUGGABLE GENOME | blocker | 53801024 | MICONAZOLE | |