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Gene: TRMT61B |
Gene summary for TRMT61B |
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Gene information | Species | Human | Gene symbol | TRMT61B | Gene ID | 55006 |
Gene name | tRNA methyltransferase 61B | |
Gene Alias | TRMT61B | |
Cytomap | 2p23.2 | |
Gene Type | protein-coding | GO ID | GO:0000154 | UniProtAcc | Q9BVS5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55006 | TRMT61B | LZE4T | Human | Esophagus | ESCC | 2.34e-13 | 3.52e-01 | 0.0811 |
55006 | TRMT61B | LZE7T | Human | Esophagus | ESCC | 2.07e-06 | 4.26e-01 | 0.0667 |
55006 | TRMT61B | LZE8T | Human | Esophagus | ESCC | 3.81e-06 | 9.85e-02 | 0.067 |
55006 | TRMT61B | LZE20T | Human | Esophagus | ESCC | 3.16e-02 | 8.46e-02 | 0.0662 |
55006 | TRMT61B | LZE22T | Human | Esophagus | ESCC | 3.49e-03 | 3.09e-01 | 0.068 |
55006 | TRMT61B | LZE24T | Human | Esophagus | ESCC | 1.98e-12 | 3.35e-01 | 0.0596 |
55006 | TRMT61B | LZE21T | Human | Esophagus | ESCC | 2.54e-03 | 3.28e-01 | 0.0655 |
55006 | TRMT61B | LZE6T | Human | Esophagus | ESCC | 1.77e-03 | 2.60e-01 | 0.0845 |
55006 | TRMT61B | P1T-E | Human | Esophagus | ESCC | 3.67e-08 | 2.68e-01 | 0.0875 |
55006 | TRMT61B | P2T-E | Human | Esophagus | ESCC | 4.80e-34 | 6.51e-01 | 0.1177 |
55006 | TRMT61B | P4T-E | Human | Esophagus | ESCC | 3.46e-23 | 4.12e-01 | 0.1323 |
55006 | TRMT61B | P5T-E | Human | Esophagus | ESCC | 1.60e-15 | 2.11e-01 | 0.1327 |
55006 | TRMT61B | P8T-E | Human | Esophagus | ESCC | 3.87e-18 | 2.19e-01 | 0.0889 |
55006 | TRMT61B | P9T-E | Human | Esophagus | ESCC | 1.83e-15 | 2.82e-01 | 0.1131 |
55006 | TRMT61B | P10T-E | Human | Esophagus | ESCC | 2.33e-19 | 3.85e-01 | 0.116 |
55006 | TRMT61B | P11T-E | Human | Esophagus | ESCC | 2.57e-11 | 4.10e-01 | 0.1426 |
55006 | TRMT61B | P12T-E | Human | Esophagus | ESCC | 8.10e-24 | 4.38e-01 | 0.1122 |
55006 | TRMT61B | P15T-E | Human | Esophagus | ESCC | 1.30e-19 | 3.35e-01 | 0.1149 |
55006 | TRMT61B | P16T-E | Human | Esophagus | ESCC | 5.87e-25 | 3.46e-01 | 0.1153 |
55006 | TRMT61B | P17T-E | Human | Esophagus | ESCC | 3.03e-06 | 1.74e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00009592 | Esophagus | ESCC | mitochondrial RNA metabolic process | 39/8552 | 49/18723 | 1.20e-06 | 1.49e-05 | 39 |
GO:00009631 | Esophagus | ESCC | mitochondrial RNA processing | 19/8552 | 20/18723 | 3.83e-06 | 4.14e-05 | 19 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00800092 | Esophagus | ESCC | mRNA methylation | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00165561 | Esophagus | ESCC | mRNA modification | 21/8552 | 27/18723 | 6.88e-04 | 3.61e-03 | 21 |
GO:0090646 | Esophagus | ESCC | mitochondrial tRNA processing | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRMT61B | SNV | Missense_Mutation | novel | c.607N>C | p.Ser203Arg | p.S203R | Q9BVS5 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TRMT61B | SNV | Missense_Mutation | novel | c.1333N>A | p.Pro445Thr | p.P445T | Q9BVS5 | protein_coding | tolerated(0.06) | possibly_damaging(0.842) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRMT61B | SNV | Missense_Mutation | novel | c.481N>G | p.Thr161Ala | p.T161A | Q9BVS5 | protein_coding | tolerated(0.53) | benign(0.028) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRMT61B | SNV | Missense_Mutation | c.500N>C | p.Lys167Thr | p.K167T | Q9BVS5 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRMT61B | SNV | Missense_Mutation | novel | c.1033N>T | p.Val345Phe | p.V345F | Q9BVS5 | protein_coding | tolerated(0.05) | benign(0.047) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRMT61B | SNV | Missense_Mutation | novel | c.640N>T | p.Pro214Ser | p.P214S | Q9BVS5 | protein_coding | deleterious(0.01) | probably_damaging(0.99) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRMT61B | SNV | Missense_Mutation | novel | c.363N>A | p.Asp121Glu | p.D121E | Q9BVS5 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
TRMT61B | SNV | Missense_Mutation | novel | c.176G>T | p.Arg59Met | p.R59M | Q9BVS5 | protein_coding | deleterious_low_confidence(0.05) | benign(0.359) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TRMT61B | SNV | Missense_Mutation | novel | c.683C>T | p.Ala228Val | p.A228V | Q9BVS5 | protein_coding | deleterious(0.02) | benign(0.095) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TRMT61B | SNV | Missense_Mutation | rs747771825 | c.128C>T | p.Ser43Leu | p.S43L | Q9BVS5 | protein_coding | tolerated_low_confidence(0.07) | benign(0.003) | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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